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Patients With Hip Osteoarthritis Have a Phenotype With High Bone Mass and Low Lean Body Mass

  • Basic Research
  • Published:
Clinical Orthopaedics and Related Research®

A CORR Insights to this article was published on 09 January 2014

Abstract

Background

Although hip osteoarthritis (OA) is common, its etiology is poorly understood. Specifically, it is not known whether hip OA is associated with abnormal relationships among the anthropometric and musculoskeletal characteristics that are associated with OA in general.

Questions

We asked whether patients with primary hip OA have a phenotype with higher bone mineral density (BMD), higher BMI, larger skeletal size, lower lean body mass, and higher fat content.

Material and Methods

We included 30 women and 32 men (mean age, 66 years; range, 42–84 years) with primary hip OA and 96 women and 91 men as control subjects. Dual energy x-ray absorptiometry was used to measure total body BMD (g/cm2), femoral neck width (cm), fat and lean mass (%), and BMI (kg/m2). Z scores were calculated for each individual. Data are presented as means with 95% CI.

Results

Women with hip OA had the following Z scores: total body BMD 0.6 (0.3, 1.0); BMI 0.6 (0.2, 1.0); femoral neck width 0.2 (−0.6, 1.0); percent total body lean mass −0.9 (−1.2, −0.5); and percent total body fat mass 0.6 (0.2, 0.9). Men with hip OA had the following mean Z scores: total body BMD 0.5 (0.0, 1.0); BMI 0.8 (0.3, 1.3); femoral neck width 0.4 (0.01, 0.9); percent total body lean mass −0.8 (−1.1, −0.5); and percent total body fat mass 0.5 (0.2, 0.8).

Conclusions

Women and men with idiopathic hip OA have a phenotype with higher BMD, higher BMI, proportionally higher fat mass, and proportionally lower lean body mass. Men also have a larger skeletal size.

Clinical Relevance

A higher BMD may lead to a stiffer bone and a proportionally lower lean body mass to lower joint-protective ability, both traits probably predisposing for hip OA.

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Authors and Affiliations

  1. Clinical and Molecular Osteoporosis Research Unit, Departments of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmö, Sweden

    Magnus K. Karlsson MD, PhD, Håkan Magnusson MD, PhD, Maria C. Cöster MD, Tord vonSchewelov MD, PhD, Caroline Karlsson MD, PhD & Björn E. Rosengren MD, PhD

Authors
  1. Magnus K. Karlsson MD, PhD
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  2. Håkan Magnusson MD, PhD
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  3. Maria C. Cöster MD
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  4. Tord vonSchewelov MD, PhD
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  5. Caroline Karlsson MD, PhD
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  6. Björn E. Rosengren MD, PhD
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Correspondence to Magnus K. Karlsson MD, PhD.

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Karlsson, M.K., Magnusson, H., Cöster, M.C. et al. Patients With Hip Osteoarthritis Have a Phenotype With High Bone Mass and Low Lean Body Mass. Clin Orthop Relat Res 472, 1224–1229 (2014). https://doi.org/10.1007/s11999-013-3395-7

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  • DOI: https://doi.org/10.1007/s11999-013-3395-7

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