Abstract
Background
Unloading knee braces often are used after tibiofemoral articular cartilage repair. However, the experimental basis for their use in patients with normal tibiofemoral alignment such as those undergoing cartilage repair is lacking.
Questions/purposes
The purpose of this study was to investigate the effect of varus and valgus adjustments to one commercially available unloader knee brace on tibiofemoral joint loading and knee muscle activation in populations with normal knee alignment.
Methods
The gait of 20 healthy participants (mean age 28.3 years; body mass index 22.9 kg/m2) was analyzed with varus and valgus knee brace conditions and without a brace. Spatiotemporal variables were calculated as were knee adduction moments and muscle activation during stance. A directed cocontraction ratio was also calculated to investigate the relative change in the activation of muscles with medial (versus lateral) moment arms about the knee. Group differences were investigated using analysis of variance. The numbers available would have provided 85% power to detect a 0.05 increase or decrease in the knee adduction moment (Nm/kg*m) in the braced condition compared with the no brace condition.
Results
With the numbers available, there were no differences between the braced and nonbraced conditions in kinetic or muscle activity parameters. Both varus (directed cocontraction ratio 0.29, SD 0.21, effect size 0.95, p = 0.315) and valgus (directed cocontraction ratio 0.28, SD 0.24, effect size 0.93, p = 0.315) bracing conditions increased the relative activation of muscles with lateral moment arms compared with no brace (directed cocontraction ratio 0.49, SD 0.21).
Conclusions
Results revealed inconsistencies in knee kinetics and muscle activation strategies after varus and valgus bracing conditions. Although in this pilot study the results were not statistically significant, the magnitudes of the observed effect sizes were moderate to large and represent suitable pilot data for future work. Varus bracing increased knee adduction moments as expected; however, they produced a more laterally directed muscular activation profile. Valgus bracing produced a more laterally directed muscular activation profile; however, it increased knee adduction moments.
Clinical Relevance
When evaluating changes in knee kinetics and muscle activation together, this study demonstrated conflicting outcomes and questions the efficacy for the use of unloader bracing for people with normally aligned knees such as those after articular cartilage repair.
Similar content being viewed by others
References
Arokoski J, Jurvelin J, Vaatainen U. Normal and pathological adaptations of articular cartilage to joint loading. Scand J Med Sci Sports. 2000;10:186–198.
Barrios JA, Higginson JS, Royer TD, Davis IS. Static and dynamic correlates of the knee adduction moment in healthy knees ranging from normal to varus-aligned. Clin Biomech (Bristol, Avon). 2009;24:850–854.
Beaudreuil J, Bendaya S, Faucher M, Coudeyre E, Ribinik P, Revel M, Rannou F. Clinical practice guidelines for rest orthosis, knee sleeves, and unloading knee braces in knee osteoarthritis. Joint Bone Spine. 2009;76:629–636.
Besier TF, Sturnieks DL, Alderson JA, Lloyd DG. Repeatability of gait data using a functional hip joint centre and a mean helical knee axis. J Biomech. 2003;36:1159–1168.
Buchanan TS, Lloyd DG. Muscle activation at the human knee during isometric flexion-extension and varus-valgus loads. J Orthop Res. 1997;15:11–17.
Carter DR, Beaupre GS, Wong M, Smith RL, Andriacchi TP, Schurman DJ. The mechanobiology of articular cartilage development and degeneration. Clin Orthop. 2004:S69–77.
Delp SL, Anderson FC, Arnold AS, Loan P, Habib A, John CT, Guendelman E, Thelen DG. OpenSim: open-source software to create and analyze dynamic simulations of movement. IEEE Transactions on Bio-Medical Engineering. 2007;54:1940–1950.
Dennis AD, Komistek RD. An in vivo analysis of the effectiveness of the osteoarthritic knee brace during heel strike and midstance of gait. Acta Chir Orthop Traumatol Cech. 1999;66:323–327.
Dennis DA, Komistek RD, Nadaud MC, Mahfouz M. Evaluation of off-loading braces for treatment of unicompartmental knee arthrosis. J Arthroplasty. 2006;21:2–8.
Donnelly CJ, Elliott BC, Doyle TL, Finch CF, Dempsey AR, Lloyd DG. Changes in knee joint biomechanics following balance and technique training and a season of Australian football. Br J Sports Med. 2012;46:917–922.
Donnelly CJ, Lloyd DG, Elliott BC, Reinbolt JA. Optimizing whole-body kinematics to minimize valgus knee loading during sidestepping: implications for ACL injury risk. J Biomech. 2012;45:1491–1497.
Draganich L, Reider B, Rimington T, Piotrowski G, Mallik K, Nasson S. The effectiveness of self-adjustable custom and off-the-shelf bracing in the treatment of varus gonarthrosis. J Bone Joint Surg Am. 2006;88:2645–2652.
Ebert JR, Fallon M, Ackland TR, Wood DJ, Janes GC. Arthroscopic Matrix-Induced Autologous Chondrocyte Implantation: 2-Year Outcomes. Arthroscopy. 2012.
Ebert JR, Lloyd DG, Ackland T, Wood DJ. Knee biomechanics during walking gait following matrix-induced autologous chondrocyte implantation. Clin Biomech (Bristol, Avon). 2010;25:1011–1017.
Ebert JR, Robertson WB, Lloyd DG, Zheng MH, Wood DJ, Ackland T. A prospective, randomized comparison of traditional and accelerated approaches to postoperative rehabilitation following autologous chondrocyte implantation: 2-year clinical outcomes. Cartilage. 2010:1947603510362907.
Ebert JR, Robertson WB, Woodhouse J, Fallon M, Zheng MH, Ackland T, Wood DJ. Clinical and magnetic resonance imaging-based outcomes to 5 years after Matrix-Induced Autologous Chondrocyte Implantation to address articular cartilage defects in the knee. 39. 2011;4:753–763.
Fantini Pagani CH, Hinrichs M, Bruggemann GP. Kinetic and kinematic changes with the use of valgus knee brace and lateral wedge insoles in patients with medial knee osteoarthritis. J Orthop Res. 2012;30:1125–1132.
Fantini Pagani CH, Potthast W, Bruggemann GP. The effect of valgus bracing on the knee adduction moment during gait and running in male subjects with varus alignment. Clin Biomech (Bristol, Avon). 2010;25:70–76.
Foroughi N, Smith R, Vanwanseele B. The association of external knee adduction moment with biomechanical variables in osteoarthritis: a systematic review. Knee. 2009;16:303–309.
Gaasbeek RD, Groen BE, Hampsink B, van Heerwaarden RJ, Duysens J. Valgus bracing in patients with medial compartment osteoarthritis of the knee. A gait analysis study of a new brace. Gait & Posture. 2007;26:3–10.
Hambly K, Bobic V, Wondrasch B, Van Assche D, Marlovits S. Autologous Chondrocyte Implantation Postoperative Care and Rehabilitation: Science and Practice. Am J Sports Med. 2006;34:1–19.
Hambly K, Silvers HJ, Steinwachs M. Rehabilitation after articular cartilage repair of the knee in the football (soccer) player. Cartilage. 2011;3:50S–56S.
Harris JD, Siston RA, Brophy RH, Lattermann C, Carey JL, Flanigan DC. Failures, re-operations, and complications after autologous chondrocyte implantation - A systematic review. Osteoarthritis Cartilage. 2011;19:779–791.
Heiden TL, Lloyd DG, Ackland TR. Knee joint kinematics, kinetics and muscle co-contraction in knee osteoarthritis patient gait. Clin Biomech (Bristol, Avon). 2009;24:833–841.
Khan KM, Scott A. Mechanotherapy: how physical therapists’ prescription of exercise promotes tissue repair. Br J Sports Med. 2009;43:247–252.
Kirkley A, Webster-Bogaert S, Litchfield R, Amendola A, MacDonald S, McCalden R, Fowler P. The effect of bracing on varus gonarthrosis. J Bone Joint Surg Am. 1999;81:539–548.
Komistek RD, Dennis DA, Northcut EJ, Wood A, Parker AW, Traina SM. An in vivo analysis of the effectiveness of the osteoarthritic knee brace during heel-strike of gait. J Arthroplasty. 1999;14:738–742.
Kutzner I, Kuther S, Heinlein B, Dymke J, Bender A, Halder AM, Bergmann G. The effect of valgus braces on medial compartment load of the knee joint - in vivo load measurements in three subjects. J Biomech. 2011;44:1354–1360.
Lloyd DG, Buchanan TS. Strategies of muscular support of varus and valgus isometric loads at the human knee. J Biomech. 2001;34:1257–1267.
Niemeyer P, Pestka JM, Kreuz PC, Erggelet C, Schmal H, Suedkamp NP, Steinwachs M. Characteristic Complications After Autologous Chondrocyte Implantation for Cartilage Defects of the Knee Joint. Am J Sports Med. 2008;36:2091–2099.
Pollo FE, Otis JC, Backus SI, Warren RF, Wickiewicz TL. Reduction of medial compartment loads with valgus bracing of the osteoarthritic knee. Am J Sports Med. 2002;30:414–421.
Raja K, Dewan N. Efficacy of knee braces and foot orthoses in conservative management of knee osteoarthritis: a systematic review. Am J Phys Med Rehabil. 2011;90:247–262.
Ramsey DK, Briem K, Axe MJ, Snyder-Mackler L. A mechanical theory for the effectiveness of bracing for medial compartment osteoarthritis of the knee. J Bone Joint Surg Am. 2007;89:2398–2407.
Rannou F, Poiraudeau S, Beaudreuil J. Role of bracing in the management of knee osteoarthritis. Curr Opin Rheumatol. 2010;22:218–222.
Richards J, Sanchez-Ballester J, Jones R, Darke N, Livingstone B. A comparison of knee braces during walking for the treatment of osteoarthritis of the medial compartment of the knee. J Bone Joint Surg Br. 2005;87-B:937–939.
Saris DB, Vanlauwe J, Victor J, Haspl M, Bohnsack M, Fortems Y, Vandekerckhove B, Almqvist KF, Claes T, Handelberg F, Lagae K, van der Bauwhede J, Vandenneucker H, Yang KG, Jelic M, Verdonk R, Veulemans N, Bellemans J, Luyten FP. Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Am J Sports Med. 2008;36:235–246.
Van Assche D, Staes F, Van Caspel D, Vanlauwe J, Bellemans J, Saris DB, Luyten FP. Autologous chondrocyte implantation versus microfracture for knee cartilage injury: a prospective randomized trial, with 2-year follow-up. Knee Surg Sports Traumatol Arthrosc. 2010;18:486–495.
Wood JJ, Malek MA, Frassica FJ, Polder JA, Mohan AK, Bloom ET, Braun MM, Cote TR. Autologous Cultured Chondrocytes: Adverse Events Reported to the United States Food and Drug Administration. J Bone Joint Surg Am. 2006;88:503–507.
Acknowledgments
We thank Mr James Dunne and Mr Denny Wells for their assistance in data processing. We also thank Winthrop Professor David J. Wood for his assistance in the appropriate selection and stratification of healthy subjects to fulfill the study inclusion criteria and Drs Ben Jackson and Anne Smith for statistical assistance.
Author information
Authors and Affiliations
Corresponding author
Additional information
Funding provided by the Hollywood Private Hospital Research Foundation (JRE, TRA) and the National Health and Medical Research Council (JRE).
All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research editors and board members are on file with the publication and can be viewed on request.
Clinical Orthopaedics and Related Research neither advocates nor endorses the use of any treatment, drug, or device. Readers are encouraged to always seek additional information, including FDA-approval status, of any drug or device prior to clinical use.
Each author certifies that his or her institution approved the human protocol for this investigation, that all investigations were conducted in conformity with ethical principles of research, and that informed consent for participation in the study was obtained.
This work was performed at the School of Sport Science, Exercise and Health, University of Western Australia, Crawley, Perth, Western Australia.
About this article
Cite this article
Ebert, J.R., Hambly, K., Joss, B. et al. Does an Unloader Brace Reduce Knee Loading in Normally Aligned Knees?. Clin Orthop Relat Res 472, 915–922 (2014). https://doi.org/10.1007/s11999-013-3297-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11999-013-3297-8