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Does Tranexamic Acid Save Blood in Minimally Invasive Total Knee Arthroplasty?

  • Clinical Research
  • Published:
Clinical Orthopaedics and Related Research®

Abstract

Background

Tranexamic acid (TEA) reportedly reduces perioperative blood loss in TKA. However, whether it does so in minimally invasive TKA is not clear.

Questions/purposes

We asked whether TEA would reduce blood loss and blood transfusion requirements after minimally invasive TKA.

Patients and Methods

We prospectively enrolled 100 patients who underwent minimally invasive TKAs: 50 received one intravenous injection of TEA before deflation of the tourniquet and a control group of 50 patients received an equivalent volume of placebo. We compared changes in hemoglobin, postoperative drainage, total blood loss, and transfusion rates between the two groups.

Results

The total blood loss was less for patients in the TEA group than for the control group: 833 mL (374–1014 mL) versus 1453 mL (733–2537 mL), respectively. The rate of blood transfusion also was less for patients in the TEA group than in the control group (4% versus 20%). The hemoglobin levels on the second and fourth postoperative days were greater for patients in the TEA group than in the control group.

Conclusions

Our data suggest one intraoperative injection of TEA decreased the total blood loss and need for transfusion after minimally invasive TKA.

Level of Evidence

Level II, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung, Taiwan, ROC 

    Po-Chun Lin MD, Chi-Hsiang Hsu MD, Wun-Schen Chen MD & Jun-Wen Wang MD

Authors
  1. Po-Chun Lin MD
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  2. Chi-Hsiang Hsu MD
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  3. Wun-Schen Chen MD
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  4. Jun-Wen Wang MD
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Correspondence to Jun-Wen Wang MD.

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Each author certifies that he or she has no commercial associations (eg, consultancies, stock ownership, equity of interest, patient/licensing arrangement, etc) that might pose a conflict of interest in connection with submitted article.

One or more of the authors (PCL, CHH, WSC, JWW) has received funding from research grant from Chang Gung Memorial Hospital (CMRPG870741).

Each author certifies that his or her institution approved the human protocol for this investigation, that all investigations were conducted in conformity with ethical principles of research, and that informed consent for participation in research was obtained.

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Lin, PC., Hsu, CH., Chen, WS. et al. Does Tranexamic Acid Save Blood in Minimally Invasive Total Knee Arthroplasty?. Clin Orthop Relat Res 469, 1995–2002 (2011). https://doi.org/10.1007/s11999-011-1789-y

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  • DOI: https://doi.org/10.1007/s11999-011-1789-y

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