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Orthopaedic Case of the Month: Rapidly Progressive Shoulder Soft Tissue Mass in an 8-week-old Girl

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References

  1. Alaggio R, Barisani D, Ninfo V, Rosolen A, Coffin CM. Morphologic overlap between infantile myofibromatosis and infantile fibrosarcoma: a pitfall in diagnosis. Pediatr Dev Pathol. 2008;11:355–362.

    Article  PubMed  Google Scholar 

  2. Berenguer B, Mulliken JB, Enjolras O, Boon LM, Wassef M, Josset P, Burrows PE, Perez-Atayde AR, Kozakewich HP. Rapidly involuting congenital hemangioma: clinical and histopathologic features. Pediatr Dev Pathol. 2003;6:495–510.

    Article  PubMed  Google Scholar 

  3. Blocker S, Koenig J, Ternberg J. Congenital fibrosarcoma. J Pediatr Surg. 1987;22:665–670.

    Article  CAS  PubMed  Google Scholar 

  4. Bourgeois JM, Knezevich SR, Mathers JA, Sorensen PHB. Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors. Am J Surg Pathol. 2000;24:937–946.

    Article  CAS  PubMed  Google Scholar 

  5. Canale S, Vanel D, Couanet D, Patte C, Caramella C, Dromain C. Infantile fibrosarcoma: magnetic resonance imaging findings in six cases. Eur J Radiol. 2009;72:30–37.

    Article  PubMed  Google Scholar 

  6. Cecchetto G, Carli M, Alaggio R, Dall’Igna P, Bisogno G, Scarzello G, Zanetti I, Durante G, Inserra A, Siracusa F, Guglielmi M; Italian Cooperative Group. Fibrosarcoma in pediatric patients: results of the Italian Cooperative Group studies (1979–1995). J Surg Oncol. 2001;78:225–231.

    Article  CAS  PubMed  Google Scholar 

  7. Chung EB, Enzinger FM. Infantile myofibromatosis. Cancer. 1981;48:1807–1818.

    Article  CAS  PubMed  Google Scholar 

  8. Coffin CM, Dehner LP. Soft tissue tumors in the first year of life: a report of 190 cases. Pediatr Pathol. 1990;10:509–526.

    Article  CAS  PubMed  Google Scholar 

  9. Coffin CM, Jaszcz W, O’Shea PA, Dehner LP. So-called congenital-infantile fibrosarcoma: does it exist and what is it? Pediatr Pathol. 1994;14:133–150.

    Article  CAS  PubMed  Google Scholar 

  10. Crist WM, Anderson JR, Meza JL, Fryer C, Raney RB, Ruymann FB, Breneman J, Qualman SJ, Wiener E, Wharam M, Lobe T, Webber B, Maurer HM, Donaldson SS. Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease. J Clin Oncol. 2001;19:3091–3102.

    CAS  PubMed  Google Scholar 

  11. Enzinger FM, Weiss SW. Fibrosarcoma. In: Weiss SW, Goldblum JR, eds. Enzinger and Weiss’s Soft Tissue Tumors. 4th ed. St Louis, MO: Mosby Inc. 2001:409–441.

    Google Scholar 

  12. Ernemann U, Kramer U, Miller S, Bisdas S, Rebmann H, Brueuninger H, Zwick C, Hoffmann J. Current concepts in the classification: diagnosis and treatment of vascular anomilies. Eur J Radiol. 2010;75:2–11.

    Article  PubMed  Google Scholar 

  13. Ferrari A, Casanova M, Bisogno G, Zanetti I, Cecchetto G, DeBernardi B, Riccardi R, Tamaro P, Meazza C, Alaggio R, Ninfo V, Carli M; Italian Cooperative Group. Rhabdomyosarcoma in infants younger than one year old: a report from the Italian Cooperative Group. Cancer. 2003;97:2597–2604.

    Article  PubMed  Google Scholar 

  14. Fisher C. Fibromatosis and fibrosarcoma in infancy and childhood. Eur J Cancer. 1996;32A:2094–2100.

    Article  CAS  PubMed  Google Scholar 

  15. Goh SG, Calonje E. Cutaneous vascular tumours: an update. Histopathology. 2008;52:661–673.

    Article  CAS  PubMed  Google Scholar 

  16. Grier HE, Perez-Atayde AR, Weinstein HJ. Chemotherapy for inoperable infantile fibrosarcoma. Cancer. 1985;56:1507–1510.

    Article  CAS  PubMed  Google Scholar 

  17. Grohn ML, Borzi P, Mackay A, Suppiah R. Management of extensive congenital fibrosarcoma with preoperative chemotherapy. ANZ J Surg. 2004;74:919–921.

    Article  CAS  PubMed  Google Scholar 

  18. Gurney JG, Smith MA, Ross JA. Cancer Among Infants. In: Cancer Incidence and Survival Among Children and Adolescents: United States SEER Program 1975–1995. National Cancer Institute, Cancer Statistics Branch, SEER Program. Bethesda, MD: National Cancer Institute; 1999; NIH Pub. No. 99-4649.

  19. Heim-Hall J, Yohe SL. Application of immunohistochemistry to soft tissue neoplasms. Arch Pathol Lab Med. 2008;132:476–489.

    PubMed  Google Scholar 

  20. Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nature Genet. 1998;18:184–187.

    Article  CAS  PubMed  Google Scholar 

  21. Koujok K, Ruiz RE, Hernandez RJ. Myofibromatosis: imaging characteristics. Pediatr Radiol. 2005;35:374–380.

    Article  PubMed  Google Scholar 

  22. Kurkchubasche AG, Halvorson EG, Forman EN, Terek RM, Ferguson WS. The role of preoperative chemotherapy in the treatment of infantile fibrosarcoma. J Pediatr Surg. 2000;35:880–883.

    Article  CAS  PubMed  Google Scholar 

  23. Kynaston JA, Malcom AJ, Craft AW, Davies SM, Jones PH, King DJ, Mitchell CD, Oakhill A, Stiller CA. Chemotherapy in the management of infantile fibrosarcoma. Med Pediatr Oncol. 1993;21:488–493.

    Article  CAS  PubMed  Google Scholar 

  24. Laffan EE, Ngan BY, Navarro OM. Pediatric soft-tissue tumors and pseudotumors: MR imaging features with pathologic correlation: Part 2: Tumors of fibroblastic/myofibroblastic, so-called fibrohistiocytic, muscular, lymphomatous, neurogenic, hair matrix and uncertain origin. Radiographics. 2009;29:e36.

    Article  PubMed  Google Scholar 

  25. Laor T. MR imaging of soft tissue tumors and tumor-like lesions. Pediatr Radiol. 2004;34:24–37.

    Article  PubMed  Google Scholar 

  26. Lee BB. Critical issues in management of congenital vascular malformation. Ann Vasc Surg. 2004;18:380–392.

    Article  CAS  PubMed  Google Scholar 

  27. Loh ML, Ahn P, Perez-Atayde AR, Gebhardt MC, Shamberger RC, Grier HE. Treatment of infantile fibrosarcoma with chemotherapy and surgery: results from the Dana-Farber Cancer Institute and Children’s Hospital, Boston. J Pediatr Hematol Oncol. 2002;24:722–726.

    Article  PubMed  Google Scholar 

  28. Mentzel T, Calonje E, Nascimento AG, Fletcher CDM. Infantile hemangiopericytoma versus infantile myofibromatosis: study of a series suggesting a continuous spectrum of infantile myofibroblastic lesions. Am J Surg Pathol.1994;18:922–930.

    Article  CAS  PubMed  Google Scholar 

  29. Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 1982;69:412–422.

    Article  CAS  PubMed  Google Scholar 

  30. Orbach D, Rey A, Cecchetto C, Oberlin O, Casanova M, Thebaud E, Scopinaro M, Bisogno G, Carli M, Ferrari A. Infantile fibrosarcoma: management based on the European experience. J Clin Oncol. 2010;28:318–323.

    Article  PubMed  Google Scholar 

  31. Pastore G, Peris-Bonet R, Carli M, Martínez-García C, Sánchez de Toledo J, Steliarova-Foucher E. Childhood soft tissue sarcomas incidence and survival in European children (1978–1997): report from the Automated Childhood Cancer Information System project. Eur J Cancer. 2006;42:2136–2149.

    Article  PubMed  Google Scholar 

  32. Pritchard DJ, Soule EH, Taylor WF, Ivins JC. Fibrosarcoma: a clinicopathologic and statistical study of 199 tumors of the soft tissues of the extremities and trunk. Cancer. 1974;33:888–897.

    Article  CAS  PubMed  Google Scholar 

  33. Sandberg AA, Bridge JA. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: congenital (infantile) fibrosarcoma and mesoblastic nephroma. Cancer Genet Cytogenet. 2002;132:1–13.

    Article  CAS  PubMed  Google Scholar 

  34. Sheng WQ, Hisaoka M, Okamoto S, Tanaka A, Meis-Kindblom JM, Kindblom LG, Ishida T, Nojima T, Hashimoto H. Congenital-infantile fibrosarcoma: a clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissues. Am J Clin Pathol. 2001;115:348–355.

    Article  CAS  PubMed  Google Scholar 

  35. Soper JR, De Silva M. Infantile myofibromatosis: a radiologic review. Pediatr Radiol. 1993;23:189–194.

    Article  CAS  PubMed  Google Scholar 

  36. Soule EH, Pritchard DJ. Fibrosarcoma in infants and children: a review of 110 cases. Cancer. 1977;40:1711–1721.

    Article  CAS  PubMed  Google Scholar 

  37. Surico G, Muggeo P, Daniele RM, Novielli C, Rigillo N, Minervini C. Letters to the Editor. Chemotherapy alone for the treatment of congenital fibrosarcoma: is surgery always needed? Med Pediatr Oncol. 2003;40:268–270.

    Article  PubMed  Google Scholar 

  38. Wexler LH, Helman LJ. Pediatric soft tissue sarcomas. CA Cancer J Clin. 1994;44:211–247.

    Article  CAS  PubMed  Google Scholar 

  39. Wiswell TE, Davis J, Cunningham BE, Solenberger R, Thomas PJ. Infantile myofibromatosis: the most common fibrous tumor of infancy. J Pediatr Surg. 1988;23:315–318.

    Article  CAS  PubMed  Google Scholar 

  40. Yan AC, Chamlin SL, Liang MG, Hoffman B, Attiyeh EF, Chang B, Honig PJ. Congenital infantile fibrosarcoma: a masquerader of ulcerated hemangioma. Pediatr Dermatol. 2006;23:330–334.

    Article  PubMed  Google Scholar 

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Acknowledgment

We thank Dr. Milan Stevanovic for microsurgery expertise and Dr. William A. May for contributions to the discussion and management regarding chemotherapy for this patient.

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Correspondence to Alexandre Arkader MD.

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Each author certifies that he or she has no commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article.

Each author confirms that his or her institution has approved the reporting of this case report and that all investigations were conducted in conformity with ethical principles of research.

This work was performed at Children’s Hospital of Los Angeles.

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Behnke, N.M., Patel, M., Davidson, T. et al. Orthopaedic Case of the Month: Rapidly Progressive Shoulder Soft Tissue Mass in an 8-week-old Girl. Clin Orthop Relat Res 469, 624–629 (2011). https://doi.org/10.1007/s11999-010-1710-0

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  • DOI: https://doi.org/10.1007/s11999-010-1710-0

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