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Markers of Thrombin Generation During Resurfacing and Noncemented Total Hip Arthroplasty: A Pilot Study

  • Symposium: Papers Presented at the Hip Society Meetings 2010
  • Published:
Clinical Orthopaedics and Related Research®

Abstract

Background

Hip resurfacing arthroplasty (HRA) could be associated with an increased risk of deep vein thrombosis (DVT) compared to traditional noncemented THA because it involves greater dissection, increased kinking and distortion of the femoral vessels, takes longer to perform, and involves insertion of some cement into the femur.

Questions/purposes

Does HRA lead to greater risk of thromboembolism compared with noncemented THA?

Methods

We prospectively studied 20 patients receiving HRA and 20 receiving THA. All patients were younger than 67 years old and were similar in height, weight, American Society of Anesthesiologists status, and gender mix. Patients undergoing HRA were younger (mean, 50 versus 59 years), their surgery was longer (mean, 87 versus 65 minutes), and they required more crystalloid during surgery (mean, 2160 versus 1662 mL). Radial artery blood samples were taken at six events during surgery and assayed for prothrombin fragment F1 + 2 and thrombin-antithrombin III complex (TAT) using enzyme-linked immunosorbent assays.

Results

We observed no differences in the intraoperative increases in F1 + 2 and TAT between the two groups and no differences in surgical events.

Conclusion

Based on these data, HRA and THA should have similar risk of thromboembolism as THA based on the parameters we measured.

Level of Evidence

Level I, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence.

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Author information

Authors and Affiliations

  1. Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, USA

    Edwin P. Su MD, Nikos Chatzoudis MD & Vasileios Sioros MD

  2. Department of Anesthesiology, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA

    George Go BS & Nigel E. Sharrock BMedSci, MB, ChB

Authors
  1. Edwin P. Su MD
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  2. Nikos Chatzoudis MD
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  3. Vasileios Sioros MD
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  4. George Go BS
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  5. Nigel E. Sharrock BMedSci, MB, ChB
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Corresponding author

Correspondence to Nigel E. Sharrock BMedSci, MB, ChB.

Additional information

Each author certifies that he or she has no commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article.

Each author certifies that his or her institution approved the human protocol for this investigation, that all investigations were conducted in conformity with ethical principles of research, and that informed consent for participation in the study was obtained.

This work was performed at the Hospital for Special Surgery, New York, NY, USA.

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Su, E.P., Chatzoudis, N., Sioros, V. et al. Markers of Thrombin Generation During Resurfacing and Noncemented Total Hip Arthroplasty: A Pilot Study. Clin Orthop Relat Res 469, 535–540 (2011). https://doi.org/10.1007/s11999-010-1659-z

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  • DOI: https://doi.org/10.1007/s11999-010-1659-z

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