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MFH of Bone and Osteosarcoma Show Similar Survival and Chemosensitivity

  • Clinical Research
  • Published:
Clinical Orthopaedics and Related Research®

Abstract

Background

Patients with malignant fibrous histiocytoma of bone (MFH-B) and osteosarcoma reportedly have comparable survival rates, despite the lesser chemosensitivity of patients with MFH-B compared with those with osteosarcoma.

Questions/purposes

We therefore asked (1) whether there is a difference in the initial tumor volume, histologic response, and survival between cohorts with MFH-B and osteosarcoma, and (2) whether histologic responses and survival rates differed between two groups even after matching for volume and age.

Patients and Methods

We retrospectively compared 27 patients with Stage IIB MFH-B with 389 patients with localized osteosarcoma for initial tumor volume, age, histologic response, and survival. We compared histologic response and survival between 27 patients with MFH-B and 54 patients with osteosarcoma matched for tumor volume and age.

Results

MFH-B occurred more frequently in older patients and they presented with a smaller mean tumor volume and more frequent osteolytic pattern when compared with patients with osteosarcoma. The 5-year metastasis-free survival rates of the MFH-B and osteosarcoma groups were similar: 61.2% ± 9.7% and 61.3% ± 2.5%, respectively. We observed similar proportions of good responders to chemotherapy in the two groups, and the 5-year metastasis-free survival rates were 61.2% ± 9.7% and 70.4% ± 6.2%, respectively.

Conclusions

Patients with MFH-B and osteosarcoma have similar survival rates and histologic responses to chemotherapy. Although MFH-B and osteosarcoma differ in clinical presentation, their response pattern to contemporary therapy is similar.

Level of Evidence

Level III, prognostic study. See the Guidelines for Authors for a complete description of levels of evidence.

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Acknowledgments

We thank J.S. Koh, MD, M.S. Kim, MD, and Yijung Seo, RN for assistance with pathologic reviews and data collection.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, Korea Cancer Center Hospital, 215-4, Gongneung-dong, Nowon-gu, Seoul, 139-706, Korea

    Dae-Geun Jeon MD, Won Seok Song MD, Chang-Bae Kong MD & Soo-Yong Lee MD

  2. Department of Orthopedic Surgery, Medical School, Chonbuk National University, Jeonju, Korea

    Jung Ryul Kim MD

Authors
  1. Dae-Geun Jeon MD
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  2. Won Seok Song MD
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  3. Chang-Bae Kong MD
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  4. Jung Ryul Kim MD
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  5. Soo-Yong Lee MD
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Corresponding author

Correspondence to Dae-Geun Jeon MD.

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The authors certify that they have no commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might constitute a conflict of interest in connection with the submitted article.

The authors certify that their institution approved the human protocol for this investigation and that all investigations were conducted in conformity with ethical principles of research.

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Jeon, DG., Song, W.S., Kong, CB. et al. MFH of Bone and Osteosarcoma Show Similar Survival and Chemosensitivity. Clin Orthop Relat Res 469, 584–590 (2011). https://doi.org/10.1007/s11999-010-1428-z

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  • DOI: https://doi.org/10.1007/s11999-010-1428-z

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