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The Impact of Gender, Age, and Preoperative Pain Severity on Pain After TKA

  • Symposium: Papers Presented at the Annual Meetings of the Knee Society
  • Published:
Clinical Orthopaedics and Related Research

Abstract

Do gender and age affect knee arthroplasty outcomes? In a cohort of patients who underwent primary or revision TKA between 1996 and 2004 and responded to a followup questionnaire 2 and 5 years after arthroplasty, we investigated the impact of gender and age on the prevalence of moderate or severe post-TKA knee pain (primary TKA: 2 years, 5290; 5 years, 2602; revision TKA: 2 years, 1109; 5 years, 505). Moderate-severe pain was higher in women than men after primary TKA at 2 and 5 years (9% versus 6.6% and 7.9% versus 6.5%) and post-revision TKA at 2 and 5 years (28.6% versus 22% and 28.9% versus 18.3%). More women compared to men and fewer patients between 61 and 70 years (versus patients ≤ 60) had moderate-severe pain 2 years after primary TKA adjusting for gender, age, and preoperative pain severity. In the post-revision TKA group, the odds of moderate-severe pain were lower in patients older than 80 years (versus those ≤ 60) at 2 years and higher in patients with moderate-severe preoperative pain at 2 and 5 years postoperatively, after adjustment for gender, age, and preoperative pain severity. We conclude female gender, younger age, and worse preoperative pain predict greater risk of moderate-severe pain postoperatively in patients with primary and revision TKA.

Level of Evidence: Level II, prognostic study. See the Guidelines for Authors for a complete description of levels of evidence.

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Acknowledgments

We thank Youlonda Loechler for her help in extracting data from the Joint Registry; Scott Harmsen and Megan O’Byrne for their help in data processing, data analyses, and data checking; Ruth Brady for help with tables; and Amy Anderson for checking the data.

Author information

Authors and Affiliations

  1. Department of Health Sciences Research, Mayo Clinic School of Medicine, Rochester, MN, USA

    Jasvinder A. Singh MBBS, MPH & Sherine Gabriel MD, MSc

  2. Department of Orthopedic Surgery, Mayo Clinic School of Medicine, Rochester, MN, USA

    Jasvinder A. Singh MBBS, MPH & David Lewallen MD

  3. Rheumatology Section, Medicine Service, VA Medical Center, Rheumatology (111R), One Veteran’s Drive, Minneapolis, MN, USA

    Jasvinder A. Singh MBBS, MPH

  4. Division of Rheumatology, Department of Medicine, University of Minnesota, Minneapolis, MN, USA

    Jasvinder A. Singh MBBS, MPH

Authors
  1. Jasvinder A. Singh MBBS, MPH
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  2. Sherine Gabriel MD, MSc
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  3. David Lewallen MD
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Corresponding author

Correspondence to Jasvinder A. Singh MBBS, MPH.

Additional information

One of the authors (DL) has received royalties/speaker fees from Zimmer, Inc, Warsaw, IN; has been a paid consultant to Zimmer, Inc; has received institutional research funds from DePuy Orthopaedics, Inc, Warsaw, IN; Stryker Orthopaedics, Mahway, NJ; and Zimmer, Inc; and has received grant support by the NIH CTSA Award 1 KL2 RR024151-01 (Mayo Clinic Center for Clinical and Translational Research) and the Department of Orthopedics, Mayo Clinic School of Medicine, Rochester, MN.

Each author certifies that his or her institution has approved the human protocol for this investigation, that all investigations were conducted in conformity with ethical principles of research, and that informed consent for participation in the study was obtained.

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Singh, J.A., Gabriel, S. & Lewallen, D. The Impact of Gender, Age, and Preoperative Pain Severity on Pain After TKA. Clin Orthop Relat Res 466, 2717–2723 (2008). https://doi.org/10.1007/s11999-008-0399-9

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  • DOI: https://doi.org/10.1007/s11999-008-0399-9

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