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The Budapest meeting 2005 intensified networking on ethics of science

The case of reproductive cloning, germline gene therapy and human dignity

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Abstract

This paper reports on the meeting of the Sounding Board of the EU Reprogenetics Project that was held in Budapest, Hungary, 6–9 November 2005. The Reprogenetics Project runs from 2004 until 2007 and has a brief to study the ethical aspects of human reproductive cloning and germline gene therapy. Discussions during The Budapest Meeting are reported in depth in this paper as well as the initiatives to involve the participating groups and others in ongoing collaborations with the goal of forming an integrated network of European resources in the fields of ethics of science.

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References

  1. Wilmut, I. & Highfield, R. (2006) After Dolly. The uses and misuses of human cloning. Little, Brown, London.

    Google Scholar 

  2. Briggs, R. & King, T. J. (1952) Transplantation of living nuclei from blastula cells into enucleated frogs’ eggs. Proceedings National Academy of Sciences USA 38: 455–463.

    Article  Google Scholar 

  3. Campbell, K.H.S., McWhir, J., Ritchie, W.A. and Wilmut, A. (1996) Sheep cloned by nuclear transfer from a cultured cell line. Nature 380 (6569): 64–66.

    Article  Google Scholar 

  4. See the following report: James A. Thomson, Joseph Itskovtz-Eldor, Sander S. Shapiro, Michelle A. Walenitz, Jennifer J. Swiergiel, Vivienne S. Marshall, Jeffrey M. Jones, Embryonic Stem Cell Lines Derived from Human Blastocysts, Science, 6 Nov. 1998, Vol. 282, no. 5391, pp. 1145–1147.

    Article  Google Scholar 

  5. Thomson, J.A., Itskovitz-Eldor, J., Shapiro, S.S., Waknitz, M.A., Swiergiel, J.J., Marshall, V.S., Jones, J.M. (1998) Embryonic Stem Cell Lines Derived from Human Blastocysts. Science 282 (5391): 1145–1147.

    Article  Google Scholar 

  6. European Parliament (2000). European parliament resolution on human cloning. Brussels: European Parliament, [adopted on 07/09/2000]. Available at: http://www.europarl.europa.eu/omk/omnsapir.so/pv2?PRG=CALDOC&TPV=PROV&FILE=000907&TXTLST=1&POS=1&SDOCTA=8&Type_Doc=FIRST&LANGUE=EN

    Google Scholar 

  7. Project website: http://www.chimbrids.org/

  8. Cohen, S., Chang, A., Boyer, H. and Helling, R. (1973) Construction of biologically functional bacterial plasmids in vitro. Proceedings of the National Academy of Sciences of the United States of America, 70: 3240–3244.

    Article  Google Scholar 

  9. Quoted by Maxine Singer: Singer, M. (1977) Scientists and the control of science. New Scientist 74 (1056): 631–634.

    Google Scholar 

  10. Singer, M. & Soll, D. (1973) Guidelines for DNA Hybrid Molecules. Science 181 (Sept 21): 1114.

    Article  Google Scholar 

  11. Berg, P. et al (1974) Potential Biohazards of Recombinant DNA Molecules. Science 185 (July 26): 303.

    Article  Google Scholar 

  12. Berg, P., Baltimore, D., Brenner, S., Roblin III, R.O., Singer, M.F. (1975) Asilomar Conference on Recombinant DNA Molecules. Science 188 (June 6): 991.

    Article  Google Scholar 

  13. Barritt, J.A., Brenner, C.A., Malter, H.E. and Cohen, J. (2001) Mitochondria in human offspring derived from ooplasmic transplantation: Brief communication. Human Reproduction 16 (3): 513–516. Available at: http://humrep.oxfordjournals.org/cgi/reprint/16/3/513

    Article  Google Scholar 

  14. Genetically altered babies born. BBC News, Friday, 4 May, 2001. Available at: http://news.bbc.co.uk/1/hi/sci/tech/1312708.stm

  15. United Nations Declaration on Human Cloning. Resolution 59/280. Available at: http://daccessdds.un.org/doc/UNDOC/GEN/N04/493/06/PDF/N0449306.pdf?OpenElement

  16. United Nations Declaration on Human Cloning. Resolution 59/280. Available at: http://daccessdds.un.org/doc/UNDOC/GEN/N04/493/06/PDF/N0449306.pdf?OpenElement

  17. See further: —— (2005) The United Nations Declaration on Human Cloning (Editorial). Law and the Human Genome Review 22: 15–24.

    Google Scholar 

  18. Holm, S. (2004) Importance of bioethics education for (hospital) health care personnel in Western European countries. European Society for Clinical Investigation (ESCI) 38th Annual Scientific Meeting — Workshop on the European Hospital (-Based) Bioethics Programme — EHBP. Utrecht.

  19. Pegoraro, R., Putoto, G. and Semplicini, A. eds (2006) Hospital Based Bioethics: A European Perspective. Piccin Nuova Libraria, Padova. (in press).

    Google Scholar 

  20. Arend, A. van der (2003) Content and use of codes of ethics in nursing. Nursing Ethics 10 (1): 97–98. Research abstract Project website: http://www.zw.unimaas.nl/ecn/

    Article  Google Scholar 

  21. Project website: http://www.eurosocap.org/

  22. McClelland, R. et al (2005) European Standards on Confidentiality and Privacy in Healthcare. Available at: http://www.eurosocap.org/Downloads/European-Standards-on-Confidentiality-and-Privacy-in-Healthcare.pdf McClelland, R. et al (2005) European Guidance for Healthcare Professionals on Confidentiality and Privacy in Healthcare. Available at: http://www.eurosocap.org/Downloads/European-Guidance-for-Healthcare-Professionals-on-Confidentiality-and-Privacy-in-Healthcare.pdf

  23. Cross, L. (2005) The 6th Global Forum on Bioethics in Research: “What happens when the research is over? Post-trial responsibilities of researchers and sponsors.”: Summary of feedback from delegates. [The 6th Global Forum on Bioethics in Research: 17–19 March 2005, Blantyre, Malawi]. Available at: http://www.wellcome.ac.uk/assets/wtx027291.pdf Website: http://www.gfbronline.com/

  24. Project website: http://www.eureca.manchester.ac.uk/

  25. Project website: http://www.ecagents.org/

  26. Project website: http://www.neurobotics.info/

  27. Pitt, J. ed. (2002) D5: Communicative Framework; D6: Agent Society Framework. ALFEBIITE Consortium. Pitt, J. ed. (2002) Deliverables D5 & D6: Annex 1 Workpackages Progress Reports. ALFEBIITE Consortium. Available at: http://alfebiite.ee.ic.ac.uk/Templates/publicdocs.htm Project website: http://alfebiite.ee.ic.ac.uk/

  28. Project website: http://www.respectproject.org

  29. Dench, S., Iphofen, R., Huws, U. (2004) An EU-Code socio-economic research. IES Report 412. Institute for Employment Studies, Brighton. Available at: http://www.respectproject.org/ethics/412ethics.pdf Schryvers, E., Van Gyes, G., Vandenbrande, T. (2004) Functional map of a European socioeconomic research project. IES Report 414. Institute for Employment Studies, Brighton. Available at: http://www.respectproject.org/quals/414qualsmap.pdf

    Google Scholar 

  30. Bruce, D. (2005) Nano-2-Life Ethics: A Scoping Paper on Ethical and Social Issues in Nanobiotechnologies, [Word-file]. Available at: http://files.nanobio-raise.org/Downloads/nanodb.doc Hauptman, A. and Sharan, Y. (2006) Envisioned developments in Nanobiotechnology: expert survey. Interdisciplinary Center for Technology Analysis and Forecasting (ICTAF) at Tel-Aviv University, Tel-Aviv. Available at: http://www.ictaf.tau.ac.il/N2L_expert_survey_results.pdf Project website: http://www.nano2life.org

  31. Türk, V., Kaiser, C., Liedtke, Chr., Knowles, H., Murray, V., Schaller, S., Wallbaum, H., Kastenholz, H., Köhler, A.R. (2006) Nanologue: Opinions on the Ethical, Legal and Social Aspects of Nanotechnologies: Results from a Consultation with Representatives from Research, Business and Civil Society. [Wuppertal Institute, etc.]. Available at: http://www.nanologue.net/index.php?seite=111 Project website: http://www.nanologue.net/

  32. Bennett, D.J. and Schuurbiers, D. (2005) Nanobiotechnology: responsible action on issues in society and ethics. NSTI-Nanotech 2: 765–768. Project website: http://nanobio-raise.org/

    Google Scholar 

  33. Zucco, F. et al (2004) Alternative methods in animal experimentation: evaluating scientific, ethical and social issues in the 3Rs context: final report and recommendations D8. Available at: http://ec.europa.eu/research/biosociety/pdf/anim_al_see_final_report.pdf Project website: http://www.inemm.cnr.it/animalsee/presentation.html

  34. Coff, Chr. Ethical Traceability and Informed Choice in Food Ethical Issues, [Project information/introduction]. Available at: http://www.ethiclaw.dk/publication/Ethical%20Trace%20homepag%233EF35.pdf Project website: http://www.food-ethics.net/

  35. Pinard-van der Laan, M.-H. Genomics to advance animal health: Eadgene: Network of Excellence. Available at: http://www.eadgene.org/HNB/eadgene/eadgene.nsf/container/1/$file/Fiche_EC_TP5-OEEADGENE.pdf Pinard-van der Laan, M.-H. Eadgene: European Animal Disease Genomics Network of Excellence for animal health and food safety. [Introduction to the project. Power Point Presentation]. Available at: http://www.fp6-food.ru/symposium/docs/es-report/20%20Van%20der%20Lann.ppt Project website: http://www.eadgene.org

  36. -- (2004) Property Rights in Plant and Animals Genomes, with special attention to Sustainable Development, Biodiversity and Food Production: Ordre Public and the Commons as Models of Regulation in Intellectual Property Rights: 27–28th November 2004, Orenas Castle, Lund, Sweden. Available at: http://www.propeur.bham.ac.uk/theme3.htm (2005) PropEur Workshop on Property Rights in Human Tissue: Property Regulation in European Science, Ethics and Law (PropEur): Workshop I:Donation/gift and Conditional Gift Models of Regulation in Intellectual Property Rights: 21–22nd January, 2005. Tuebingen Castle, Tuebingen, Germany: Workshop Report. Available at: http://www.propeur.bham.ac.uk/theme4.htm Project website: http://www.propeur.bham.ac.uk/

  37. BABAS (1999) Ethical Aspects of Agricultural Biotechnology. European Federation of Biotechnology, The Hague. Available at: http://files.efbpublic.org/downloads/ethical.pdf

    Google Scholar 

  38. Project website: http://www.ethicaltools.info/

  39. Beekman, V., Bakker, E. de, Baranzke, H., et al. (2006) Ethical Bio-Technology Assessment Tools for Agriculture and Food Production: Final Report Ethical Bio-TA Tools (QLG6-CT-2002-02594). LEI, The Hague. Available at: http://www.ethicaltools.info/content/ET1%20Final%20Report%20(Binnenwerk%2059p).pdf

    Google Scholar 

  40. Gjerris, M. & Vajta, G. The Science and Technology of Farm Animal Cloning: A review of the state of the art of the science, the technology, the problems and the possibilities. [Danish Centre for Bioethics and Risk Assessment (CeBRA)]. Meyer, G. Why clone farm animals? Goals, motives, assumptions, values and concerns among European scientists working with cloning of farm animals. [Danish Centre for Bioethics and Risk Assessment (CeBRA)]. Institute of Prospective Technological Studies (DG JRC-IPTS, Sustainability in Agriculture, Food and Health Unit), Danish Centre for Bioethics and Risk Assessment (CeBRA) & DG RTD (Biotechnology, Agriculture and Food directorate) (2005) Animal Cloning: Technology, Applications and Ethics: Expert Workshop Conclusions. [European Commission, Seville]. Available at: http://www.sl.kvl.dk/cloninginpublic/index-filer/Page460.htm Project website: http://www.sl.kvl.dk/cloninginpublic/index-filer/Page361.htm

  41. Raeymaekers, P., Rondia, K., Slob, M. eds. (2004) Connecting Brains and Society: the present and future of brain science: what is possible, what is desirable?: European Workshop 22 and 23 April 2004 Amsterdam the Netherlands, Proceedings and Synthesis report. King Baudouin Foundation [etc.], Brussels [etc.]. Project website: http://www.meetingmindseurope.org

    Google Scholar 

  42. Dickson, E., Rondia, K. & Slob, M. eds (2006) European Citizens’ Assessment Report: complete results: 37 recommendations on Brain Science, Meeting of Minds Partner Consortium, [Brussels]. Est, R. van & Fischer, A. eds (2006) European Citizens’ Deliberation on Brain Science: January 20–23, 2006: Brussels, Belgium: European Citizens’ Assessment Report. ource: http://www.meetingmindseurope.org/europe_default_site.aspx?SGREF=16

  43. Est, R. van & Fischer, A. eds (2006) European Citizens’ Deliberation on Brain Science: January 20–23, 2006: Brussels, Belgium: European Citizens’ Assessment Report: 38.

  44. Novotny, T.E., Mordini, E., Chadwick, R., Pederson, J.M., Fabbri, F., Lie Reidar, Thanachaiboot, N., Mossialos, E., Permanand, G. (2006) Bioethical implications of globalization: An international consortium project of the European Commission. PLoS Medicine 3: e43. Available at: http://www.globalhealthsciences.ucsf.edu/about/bios/Bioethical%20Implications% 20of%20Globalization.pdf Project website: http://www.bigproject.org/

  45. -- (2005) Sharing the fruits of genomics with the developing world [Leaflet; Project information]. Available at: http://www.eubuero.de/arbeitsbereiche/wissenschaftundgesellschaft/projekte/ Download/dat_/fil_1300 Project website: http://www.uclan.ac.uk/facs/health/ethics/staff/publications/doris%20besha.htm

  46. -- The CTC Ethics Focus Group Discussion Guide. Available at: http://www.bioethics.it/pdf/pu_4/the_ctc_ethics_focus_group_discussion_guide.pdf-- Ethical issues in clinical trial collaborations with developing countries: Focus group report. Available at: http://www.bioethics.it/pdf/pu_4/ctc_ethics_focus_group_report.pdf Project website: http://www.ethica.uib.no/level/ctc.html

  47. -- EDCEP: European and Developing Countries Ethics Partnership, [Introduction]. Available at: http://www.bioethics.it/pdf/pc_4/edcep_pagina_introduttiva.pdf Lie, R.K. et al (2003) European and Developing Countries Ethics Partnership: EDCEP, [Project Proposal Part B]. Available at: http://www.bioethics.it/pdf/pc_4/edcep.pdf

  48. —— (2005) Ethics of research overseas, in: Medical Research Council: Annual Report and Accounts 2004–2005, The Stationary Office, London, 36. Available at: http://www.mrc.ac.uk/pdf-annual_report_2004_2005.pdf INSERM (2005) Partenaires africains et européens s’unissent pour favoriser l’éthique dans la recherche médicale, [Press release]. Available at: http://ist.inserm.fr/basispresse/CPI/CPI2005/27janvier2005.pdf Shette, P. (2005) Africa and Europe create ethics network. Available at: SciDev.Net: http://www.scidev.net/News/index.cfm?fuseaction=readnews&itemid=1886&language=1

    Google Scholar 

  49. UNESCO (2005) Universal Declaration on Bioethics and Human Rights. Available at: http://portal.unesco.org/shs/en/file_download.php/46133e1f4691e4c6e57566763d474a4dBioethicsDeclaration_EN.pdf

  50. United Nations (1948) Universal Declaration of Human Rights, adopted on 10 December 1948. Available at: http://www.unhchr.ch/udhr/index.htm

  51. European Commission. Directorate General Press and Communication (2005) Social values, Science and Technology. (Special Eurobarometer 225, June 2005). Available at: http://ec.europa.eu/public_opinion/archives/ebs/ebs_225_report_en.pdf

  52. See page 37 of Social values, Science and Technology. (Special Eurobarometer 225, June 2005)

  53. See page 22 of Social values, Science and Technology. (Special Eurobarometer 225, June 2005)

  54. See page 55 of Social values, Science and Technology. (Special Eurobarometer 225, June 2005)

  55. Project website: http://130.251.107.180/biotethics/. The consortium produced a textbook in Biotechnology Ethics: Landeweerd, L., Houdebine, L.-M., Termeulen, R. eds. (2005) BioTechnology-Ethics: an introduction, Pontecorboli, Florence.

    Google Scholar 

  56. See above: Topic in Focus 2: Germline Gene Therapy: The world in 2025. (Three major points of discussion: 1. Safety issues)

  57. Voorthuizen, L. van (1993) The signaling and articulation of ethical aspects regarding genetic modification of animals. A comparative study of an organized public debate and the opinion of ethicists. Center for Bioethics and Health Law (now Ethics Institute Utrecht), Utrecht. The report is only available in Dutch

  58. Hüsing, B. (2003) Increasing Public Involvement in Debates on Ethical Questions of Xenotransplantation: Monitoring of International Developments in Xenotransplantation: Baseline Evaluation. Institute for Advanced Studies (IHS), Vienna. Available at: http://www.ihs.ac.at/departments/soc/xeno-pta/xeno_huesing.pdf Santos, D. and Munoz, E. (2003) Increasing Public Involvement in Debates on Ethical Questions of Xenotransplantation: National Report Baseline Evaluation: Spain. Institute for Advanced Studies (IHS), Vienna. Available at: http://www.ihs.ac.at/departments/soc/xenopta/xeno_Spain.pdf

    Google Scholar 

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  1. International Forum for Biophilosophy, Craenendonck 15, B-3000, Leuven, Belgium

    Guido Van Steendam (Director)

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Correspondence to Guido Van Steendam.

Additional information

For more information about the authors of this summary article, researchers on the Reprogenetics project and participants in The Budapest Meeting and follow-up workshop, see pp. 792–793.

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Van Steendam, G., Dinnyés, A., Mallet, J. et al. The Budapest meeting 2005 intensified networking on ethics of science. SCI ENG ETHICS 12, 731–793 (2006). https://doi.org/10.1007/s11948-006-0067-y

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