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Development of Controlled Delivery Functional Systems by Microencapsulation of Different Extracts of Plants: Hypericum perforatum L., Salvia officinalis L. and Syzygium aromaticum

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Abstract

Extracts of different plants (Hypericum perforatum L., Salvia officinalais L. and Syzygium aromaticum) were microencapsulated. Different microparticles were prepared by a spray drying process, and they were fully characterized and evaluated in terms of controlled release. The product yield of the spray dryer varied from 26.5 to 65.5 wt%. All the microparticles present a regular shape, a very smooth surface and a mean size smaller than 20 μm. The total release was achieved in less than 70 min. The encapsulation efficiency was around 100%. The release profiles were simulated and evaluated using different kinetic models: Korsmeyer-Peppas (R2: 0.795–0.992), Weibull (R2: 0.973–0.999) and Baker–Lonsdale (R2: 0.855–0.964). These mathematical models allowed the evaluation of the mass transport mechanisms involved in the release, which, in turn, helps to design a system with specific characteristics. Finally, the Weibull model presents a better adjustment to the experimental release profiles, and the drug transport mechanism involved in almost all the release profiles studied is by an anomalous transport.

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Data Availability

Data that support the findings of this study are available on request from the authors.

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Acknowledgements

Berta Estevinho acknowledges Fundação para a Ciência e a Tecnologia (FCT) for the contract based on the “Lei do Emprego Científico” (DL 57/2016).

Funding

This work was financially supported by project UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology and Energy (LEPABE), funded by national funds through the FCT/MCTES (PIDDAC); Project POCI-01-0145-FEDER-028715 (MicroDelivery — development of controlled delivery functional systems by microencapsulation of natural and active compounds with therapeutic, nutritional and technological interest) and funded by FEDER funds through COMPETE2020 – Programa Operacional Competitividade e Internacionalização (POCI) and by national funds (PIDDAC) through FCT/MCTES.

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Authors and Affiliations

  1. LEPABE, Departamento de Engenharia Química, Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, 4200-465, Porto, Portugal

    Berta N. Estevinho, Ioana-Luiza Horciu & Fernando Rocha

  2. Faculty of Chemical Engineering and Environmental Protection, Department of Organic, Biochemical and Food Engineering, “Gheorghe Asachi” Technical University of Iasi, 73 D. Mangeron, 700050, Iasi, Romania

    Ioana-Luiza Horciu & Alexandra-Cristina Blaga

Authors
  1. Berta N. Estevinho
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  2. Ioana-Luiza Horciu
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  3. Alexandra-Cristina Blaga
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  4. Fernando Rocha
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Correspondence to Berta N. Estevinho.

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Estevinho, B.N., Horciu, IL., Blaga, AC. et al. Development of Controlled Delivery Functional Systems by Microencapsulation of Different Extracts of Plants: Hypericum perforatum L., Salvia officinalis L. and Syzygium aromaticum. Food Bioprocess Technol 14, 1503–1517 (2021). https://doi.org/10.1007/s11947-021-02652-9

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  • DOI: https://doi.org/10.1007/s11947-021-02652-9

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