Opinion statement
There are no standard guidelines for treatment of spinal cord ischemia due to how rare it is and the diverse etiology and presentations involved. In addition, to date, there have been no large clinical trials examining ideal pharmacologic treatment options for spinal cord infarct. In our practice, we rely on hemodynamic augmentation initiated as soon as possible. Otherwise, treatment is usually geared towards the etiology of spinal cord ischemia. For instance, spinal cord ischemia occurring after aortic aneurysmal repair may improve with CSF drainage through a lumbar catheter in the periprocedural setting. Vertebral artery dissection should be treated with antithrombotics. If no clear etiology is found and there is evidence of atherosclerosis in other vascular beds, then management is focused on risk factor modification with blood pressure and glucose control, statins, and antithrombotics.
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Rubin MN, Rabinstein AA. Vascular diseases of the spinal cord. Neurol Clin. 2013;31(1):153–81.
Sandson TA, Friedman JH. Spinal cord infarction. Report of 8 cases and review of the literature. Medicine. 1989;68(5):282–92.
Naess H, Romi F. Comparing patients with spinal cord infarction and cerebral infarction: clinical characteristics, and short-term outcome. Vasc Health Risk Manag. 2011;7:497–502.
Bosmia AN, Tubbs RS, Hogan E, Bohnstedt BN, Denardo AJ, Loukas M, et al. Blood supply to the human spinal cord: part II. Imaging Pathol Clin Anatomy. 2015;28(1):65–74.
Biglioli P, Roberto M, Cannata A, Parolari A, Fumero A, Grillo F, et al. Upper and lower spinal cord blood supply: the continuity of the anterior spinal artery and the relevance of the lumbar arteries. J Thorac Cardiovasc Surg. 2004;127(4):1188–92.
Novy J, Carruzzo A, Maeder P, Bogousslavsky J. Spinal cord ischemia: clinical and imaging patterns, pathogenesis, and outcomes in 27 patients. Arch Neurol. 2006;63(8):1113–20.
Kim SW, Kim RC, Choi BH, Gordon SK. Non-traumatic ischaemic myelopathy: a review of 25 cases. Paraplegia. 1988;26(4):262–72.
Cheng MY, Lyu RK, Chang YJ, Chen RS, Huang CC, Wu T, et al. Spinal cord infarction in Chinese patients. Clinical features, risk factors, imaging and prognosis. Cerebrovasc Dis. 2008;26(5):502–8.
Maharaj MM, Phan K, Hariswamy S, Rao PJ. Surfer’s myelopathy: a rare presentation in a non-surfing setting and review of the literature. J Spine Surg. 2016;2(3):222–6.
Nakamoto BK, Siu AM, Hashiba KA, Sinclair BT, Baker BJ, Gerber MS, et al. Surfer’s myelopathy: a radiologic study of 23 cases. AJNR Am J Neuroradiol. 2013;34(12):2393–8.
Vongveeranonchai N, Zawahreh M, Strbian D, Sundararajan S. Evaluation of a patient with spinal cord infarction after a hypotensive episode. Stroke. 2014;45(10):e203–5.
Nedeltchev K, Loher TJ, Stepper F, Arnold M, Schroth G, Mattle HP, et al. Long-term outcome of acute spinal cord ischemia syndrome. Stroke. 2004;35(2):560–5.
Cheshire WP, Santos CC, Massey EW, Howard JF Jr. Spinal cord infarction: etiology and outcome. Neurology. 1996;47(2):321–30.
Herrick MK, Mills PE Jr. Infarction of spinal cord; two cases of selective gray matter involvement secondary to asymptomatic aortic disease. Arch Neurol. 1971;24(3):228–41.
Buth J, Harris PL, Hobo R, van Eps R, Cuypers P, Duijm L, et al. Neurologic complications associated with endovascular repair of thoracic aortic pathology: incidence and risk factors. A study from the European Collaborators on Stent/Graft Techniques for Aortic Aneurysm Repair (EUROSTAR) registry. J Vasc Surg. 2007;46(6):1103–10. discussion 10–1
Makaroun MS, Dillavou ED, Kee ST, Sicard G, Chaikof E, Bavaria J, et al. Endovascular treatment of thoracic aortic aneurysms: results of the phase II multicenter trial of the GORE TAG thoracic endoprosthesis. J Vasc Surg. 2005;41(1):1–9.
Stone DH, Brewster DC, Kwolek CJ, Lamuraglia GM, Conrad MF, Chung TK, et al. Stent-graft versus open-surgical repair of the thoracic aorta: mid-term results. J Vasc Surg. 2006;44(6):1188–97.
Coselli JS, LeMaire SA, Schmittling ZC, Koksoy C. Cerebrospinal fluid drainage in thoracoabdominal aortic surgery. Semin Vasc Surg. 2000;13(4):308–14.
Hsu CY, Cheng CY, Lee JD, Lee M, Huang YC, Wu CY, et al. Clinical features and outcomes of spinal cord infarction following vertebral artery dissection: a systematic review of the literature. Neurol Res. 2013;35(7):676–83.
Crum B, Mokri B, Fulgham J. Spinal manifestations of vertebral artery dissection. Neurology. 2000;55(2):304–6.
Hirose G, Kosoegawa H, Takado M, Shimazaki K, Murakami E. Spinal cord ischemia and left atrial myxoma. Arch Neurol. 1979;36(7):439.
Ghandehari K, Gerami Sarabi MR, Maarufi P. Clinical evaluation of patients with spinal cord infarction in Mashhad, Iran. Stroke Res Treat. 2010;2010:942,417.
Mateen FJ, Monrad PA, Hunderfund AN, Robertson CE, Sorenson EJ. Clinically suspected fibrocartilaginous embolism: clinical characteristics, treatments, and outcomes. Eur J Neurol. 2011;18(2):218–25.
Chang CW, Donovan DJ, Liem LK, O'Phelan KH, Green DM, Bassin S, et al. Surfers’ myelopathy: a case series of 19 novice surfers with nontraumatic myelopathy. Neurology. 2012;79(22):2171–6.
Thompson TP, Pearce J, Chang G, Madamba J. Surfer’s myelopathy. Spine. 2004;29(16):E353–6.
Freedman BA, Malone DG, Rasmussen PA, Cage JM, Benzel EC. Surfer’s myelopathy: a rare form of spinal cord infarction in novice surfers: a systematic review. Neurosurgery. 2016;78(5):602–11.
Huntley GD, Ruff MW, Hicks SB, Yost MD, Fulgham JR. Ascending spinal cord infarction secondary to recurrent spinal cord cavernous malformation hemorrhage. J Stroke Cerebrovasc Dis: Off J Nat Stroke Assoc. 2017;26(4):e72–e3.
Brinjikji W, Nasr DM, Morris JM, Rabinstein AA, Lanzino G. Clinical outcomes of patients with delayed diagnosis of spinal dural arteriovenous fistulas. AJNR Am J Neuroradiol. 2016;37(2):380–6.
• Pollock NW, Buteau D. Updates in decompression illness. Emerg Med Clin North Am. 2017;35(2):301–19. This review article provides the most up to date summary of the presentation, management, and treatment of decompression illness.
Kister I, Johnson E, Raz E, Babb J, Loh J, Shepherd TM. Specific MRI findings help distinguish acute transverse myelitis of neuromyelitis optica from spinal cord infarction. Mult Scler Relat Disord. 2016;9:62–7.
Do-Dai DD, Brooks MK, Goldkamp A, Erbay S, Bhadelia RA. Magnetic resonance imaging of intramedullary spinal cord lesions: a pictorial review. Curr Probl Diagn Radiol. 2010;39(4):160–85.
Etgen T, Hocherl C. Repeated early thrombolysis in cervical spinal cord ischemia. J Thromb Thrombolysis. 2016;42(1):142–5.
Muller KI, Steffensen LH, Johnsen SH. Thrombolysis in anterior spinal artery syndrome. BMJ Case Rep. 2012;2012
Restrepo L, Guttin JF. Acute spinal cord ischemia during aortography treated with intravenous thrombolytic therapy. Tex Heart Inst J. 2006;33(1):74–7.
• Sugiura J, Oshima H, Abe T, Narita Y, Araki Y, Fujimoto K, et al. The efficacy and risk of cerebrospinal fluid drainage for thoracoabdominal aortic aneurysm repair: a retrospective observational comparison between drainage and non-drainage dagger. Interactive cardiovascular and thoracic surgery. 2017. This is the most recent retrospective review of outcomes in TAAA patient’s with CSF drainage.
Rain S, Udding J, Broere D. Acute clinical worsening after steroid administration in cervical myelitis may reveal a subdural arteriovenous fistula. Case Rep Neurol. 2016;8(3):234–42.
Nasr DM, Brinjikji W, Rabinstein AA, Lanzino G. Clinical outcomes following corticosteroid administration in patients with delayed diagnosis of spinal arteriovenous fistulas. J Neurointervent Surg. 2016.
Robertson CE, Brown RD Jr, Wijdicks EF, Rabinstein AA. Recovery after spinal cord infarcts: long-term outcome in 115 patients. Neurology. 2012;78(2):114–21.
New PW, McFarlane CL. Survival following spinal cord infarction. Spinal Cord. 2013;51(6):453–6.
Rigney L, Cappelen-Smith C, Sebire D, Beran RG, Cordato D. Nontraumatic spinal cord ischaemic syndrome. J Clin Neurosci: Off J Neurosurg Soc Australasia. 2015;22(10):1544–9.
• Romi F, Naess H. Spinal cord infarction in clinical neurology: a review of characteristics and long-term prognosis in comparison to cerebral infarction. Eur Neurol. 2016;76(3–4):95–8. This is the most recent review of the literature to date comparing outcomes of spinal cord to cerebral infarctions.
Hanson SR, Romi F, Rekand T, Naess H. Long-term outcome after spinal cord infarctions. Acta Neurol Scand. 2015;131(4):253–7.
Heldner MR, Arnold M, Nedeltchev K, Gralla J, Beck J, Fischer U. Vascular diseases of the spinal cord: a review. Curr Treat Options Neurol. 2012;14(6):509–20.
Masson C, Pruvo JP, Meder JF, Cordonnier C, Touze E, De La Sayette V, et al. Spinal cord infarction: clinical and magnetic resonance imaging findings and short term outcome. J Neurol Neurosurg Psychiatry. 2004;75(10):1431–5.
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Nasr, D.M., Rabinstein, A. Spinal Cord Infarcts: Risk Factors, Management, and Prognosis. Curr Treat Options Neurol 19, 28 (2017). https://doi.org/10.1007/s11940-017-0464-3
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DOI: https://doi.org/10.1007/s11940-017-0464-3