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Imaging Markers for Monitoring Disease Activity in Multiple Sclerosis

  • Multiple Sclerosis and Related Disorders (P Villoslada, Section Editor)
  • Published:
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Opinion statement

Multiple sclerosis (MS) is an immune-mediated disease affecting the central nervous system (CNS). Magnetic resonance imaging (MRI) has long been recognized as an important tool in the diagnosis of MS. It is increasingly recognized that in addition to its role in diagnosis, MRI can play a key role as a noninvasive tool for prognostication, disease monitoring, assessment of treatment efficacy, and safety monitoring of disease-modifying therapies (DMTs). A confluence of factors, including increased availability of MRI, development of improved MRI techniques, and increased availability of DMTs have contributed to the expanding role of MRI in MS clinical care. As the clinical use of MRI in MS expands, it is important that MRI protocols amongst clinical centers are standardized. Here, we summarize recent evidence supporting the use of MRI in clinical practice, summarize various clinical guidelines and recommendations for the use of MRI in MS disease monitoring, and provide our recommendations for standardized MRI protocols.

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Authors and Affiliations

  1. Division of Neurology, Department of Medicine, St. Michael’s Hospital, University of Toronto, 30 Bond St. Shuter 3-019, Toronto, ON, M5B1W8, Canada

    Suradech Suthiphosuwan MD, FRCR, David Kim MD & Jiwon Oh MD, PhD, FRCPC

  2. Division of Diagnostic and Therapeutic Neuroradiology, Department of Medical Imaging, St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada

    Suradech Suthiphosuwan MD, FRCR & Aditya Bharatha MD, FRCPC

  3. Department of Clinical Neurological Sciences, Western University, London, ON, Canada

    David Kim MD

  4. Department of Neurology, Johns Hopkins University, Baltimore, MD, USA

    Jiwon Oh MD, PhD, FRCPC

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  1. Suradech Suthiphosuwan MD, FRCR
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  2. David Kim MD
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  3. Aditya Bharatha MD, FRCPC
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  4. Jiwon Oh MD, PhD, FRCPC
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Correspondence to Jiwon Oh MD, PhD, FRCPC.

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David Kim declares that he has no conflict of interest.

Suradech Suthiphosuwan has received grants from Sanofi-Genzyme.

Aditya Bharatha has received honorarium for education lectures from Novartis, Biogen, and EMD Serono.

Jiwon Oh has received a grant from the MS Society of Canada, the National MS Society, grants and consultation fees from Biogen-Idec and Sanofi-Genzyme, and consultation fees from EMD Serono, Novartis, Roche, and Teva.

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This article is part of the Topical Collection on Multiple Sclerosis and Related Disorders

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Suthiphosuwan, S., Kim, D., Bharatha, A. et al. Imaging Markers for Monitoring Disease Activity in Multiple Sclerosis. Curr Treat Options Neurol 19, 18 (2017). https://doi.org/10.1007/s11940-017-0453-6

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