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Temperature Management in the Neurointensive Care Unit

  • Critical Care Neurology (K Sheth, Section Editor)
  • Published:
Current Treatment Options in Neurology Aims and scope Submit manuscript

Opinion statement

Fever in the neurocritical care unit has a high prevalence and is associated with worse outcomes in patients with severe neurologic illness. While it is well accepted that fever is associated with worse outcomes in this patient population, it is unclear if aggressive temperature management will improve outcomes. Temperature should be monitored routinely in this high-risk population, fever worked up appropriately to identify infectious etiology, and reasonable measures taken to control elevated temperature. While infection is a common source of fever in patients with significant neurologic illness, the fever may also be exacerbated by the underlying brain injury. The clinician must decide at which point to initiate fever control measures, how aggressively to manage the fever, and which temperature to target for normothermia. Several pharmacological agents are available as first-line therapy. Depending on the degree and severity of the febrile response, advanced temperature-control devices should be added to pharmacological measures. Several types of temperature-control devices are available, including invasive (intravascular catheters) and noninvasive (external cooling pads) technologies. The clinician should utilize both pharmacologic and device-based temperature therapies to minimize the amount of time spent in a febrile state and help to mitigate the secondary brain injury brought on by fever.

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References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. O’Grady NP, Barie PS, Bartlett J, et al. Practice parameters for evaluating new fever in critically ill adult patients. Task Force of the American College of Critical Care Medicine of the Society of Critical Care Medicine in collaboration with the Infectious Disease Society of America. Crit Care Med. 1998;26(2):392–408.

    Article  PubMed  Google Scholar 

  2. Laupland KB, Shahpori R, Kirkpatrick AW, Ross T, Gregson DB, Stelfox HT. Occurrence and outcome of fever in critically ill adults. Crit Care Med. 2008;36(5):1531–5.

    Article  PubMed  Google Scholar 

  3. Kilpatrick MM, Lowry DW, Firlik AD, Yonas H, Marion DW. Hyperthermia in the neurosurgical intensive care unit. Neurosurgery. 2000;47(4):850–5. discussion 855–856.

    Article  CAS  PubMed  Google Scholar 

  4. Rincon F, Hunter K, Schorr C, Dellinger RP, Zanotti-Cavazzoni S. The epidemiology of spontaneous fever and hypothermia on admission of brain injury patients to intensive care units: a multicenter cohort study. J Neurosurg. 2014;121(4):950–60.

    Article  PubMed  Google Scholar 

  5. Greer DM, Funk SE, Reaven NL, Ouzounelli M, Uman GC. Impact of fever on outcome in patients with stroke and neurologic injury: a comprehensive meta-analysis. Stroke; J Cerebral Circulat. 2008;39(11):3029–35.

    Article  Google Scholar 

  6. Diringer MN, Reaven NL, Funk SE, Uman GC. Elevated body temperature independently contributes to increased length of stay in neurologic intensive care unit patients. Crit Care Med. 2004;32(7):1489–95.

    Article  PubMed  Google Scholar 

  7. Rincon F, Patel U, Schorr C, et al. Brain injury as a risk factor for fever upon admission to the intensive care unit and association with in-hospital case fatality: a matched cohort study. J Intensive Care Med. 2015;30(2):107–14.

    Article  PubMed  Google Scholar 

  8. Mullins ME, Empey M, Jaramillo D, Sosa S, Human T, Diringer MN. A prospective randomized study to evaluate the antipyretic effect of the combination of acetaminophen and ibuprofen in neurological ICU patients. Neurocrit Care. 2011;15(3):375–8.

    Article  CAS  PubMed  Google Scholar 

  9. Botting R. Antipyretic therapy. Front Biosci : J Virtual Library. 2004;9:956–66.

    Article  CAS  Google Scholar 

  10. Polderman KH, Herold I. Therapeutic hypothermia and controlled normothermia in the intensive care unit: practical considerations, side effects, and cooling methods. Crit Care Med. 2009;37(3):1101–20.

    Article  PubMed  Google Scholar 

  11. Hoedemaekers CW, Ezzahti M, Gerritsen A, van der Hoeven JG. Comparison of cooling methods to induce and maintain normo- and hypothermia in intensive care unit patients: a prospective intervention study. Crit Care. 2007;11(4):R91.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Niven DJ, Gaudet JE, Laupland KB, Mrklas KJ, Roberts DJ, Stelfox HT. Accuracy of peripheral thermometers for estimating temperature: a systematic review and meta-analysis. Ann Intern Med. 2015;163(10):768–77. This meta-analysis and systematic review highlights the fact that peripheral thermometers do not accurately estimate body temperature and should not be used for detecting temperature abnormalities.

    Article  PubMed  Google Scholar 

  13. Watkins PB, Kaplowitz N, Slattery JT, et al. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA : J Am Med Assoc. 2006;296(1):87–93.

    Article  CAS  Google Scholar 

  14. Scaravilli V, Tinchero G, Citerio G. Participants in the International Multi-Disciplinary Consensus Conference on the Critical Care Management of Subarachnoid H. Fever Management in SAH. Neurocrit Care. 2011;15(2):287–94.

    Article  CAS  PubMed  Google Scholar 

  15. Oddo M, Frangos S, Maloney-Wilensky E, Andrew Kofke W, Le Roux PD, Levine JM. Effect of shivering on brain tissue oxygenation during induced normothermia in patients with severe brain injury. Neurocrit Care. 2010;12(1):10–6.

    Article  CAS  PubMed  Google Scholar 

  16. Badjatia N, Strongilis E, Gordon E, et al. Metabolic impact of shivering during therapeutic temperature modulation: the Bedside Shivering Assessment Scale. Stroke; J Cerebral Circulat. 2008;39(12):3242–7.

    Article  Google Scholar 

  17. Phipps MS, Desai RA, Wira C, Bravata DM. Epidemiology and outcomes of fever burden among patients with acute ischemic stroke. Stroke; J Cerebral Circulat. 2011;42(12):3357–62.

    Article  Google Scholar 

  18. Polderman KH. Mechanisms of action, physiological effects, and complications of hypothermia. Crit Care Med. 2009;37(7 Suppl):S186–202.

    Article  PubMed  Google Scholar 

  19. den Hertog HM, van der Worp HB, van Gemert HM, et al. The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial. Lancet Neurol. 2009;8(5):434–40.

    Article  Google Scholar 

  20. Jauch EC, Saver JL, Adams Jr HP, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke; J Cerebral Circulat. 2013;44(3):870–947.

    Article  Google Scholar 

  21. Rockett H, Thompson HJ, Blissitt PA. Fever management practices of neuroscience nurses: what has changed? J Neurosci Nursing : J Am Assoc Neurosci Nurses. 2015;47(2):66–75.

    Article  Google Scholar 

  22. Thompson HJ. Evidence-base for fever interventions following stroke. Stroke; J Cerebral Circulat. 2015;46(5):e98–e100. This recent review of the literature identifies evidence-based literature for monitoring and management of the febrile patient after an acute ischemic stroke. Guidance was developed for the nursing care of the febrile stroke patient.

    Article  Google Scholar 

  23. Schwarz S, Hafner K, Aschoff A, Schwab S. Incidence and prognostic significance of fever following intracerebral hemorrhage. Neurology. 2000;54(2):354–61.

    Article  CAS  PubMed  Google Scholar 

  24. Leira R, Davalos A, Silva Y, et al. Early neurologic deterioration in intracerebral hemorrhage: predictors and associated factors. Neurology. 2004;63(3):461–7.

    Article  CAS  PubMed  Google Scholar 

  25. Rincon F, Lyden P, Mayer SA. Relationship between temperature, hematoma growth, and functional outcome after intracerebral hemorrhage. Neurocrit Care. 2013;18(1):45–53.

    Article  PubMed  Google Scholar 

  26. Broessner G, Lackner P, Fischer M, et al. Influence of prophylactic, endovascularly based normothermia on inflammation in patients with severe cerebrovascular disease: a prospective, randomized trial. Stroke; J Cerebral Circulat. 2010;41(12):2969–72.

    Article  Google Scholar 

  27. Lord AS, Karinja S, Lantigua H, et al. Therapeutic temperature modulation for fever after intracerebral hemorrhage. Neurocrit Care. 2014;21(2):200–6.

    Article  PubMed  Google Scholar 

  28. Wartenberg KE, Schmidt JM, Claassen J, et al. Impact of medical complications on outcome after subarachnoid hemorrhage. Crit Care Med. 2006;34(3):617–23. quiz 624.

    PubMed  Google Scholar 

  29. Oliveira-Filho J, Ezzeddine MA, Segal AZ, et al. Fever in subarachnoid hemorrhage: relationship to vasospasm and outcome. Neurology. 2001;56(10):1299–304.

    Article  CAS  PubMed  Google Scholar 

  30. Naidech AM, Bendok BR, Bernstein RA, et al. Fever burden and functional recovery after subarachnoid hemorrhage. Neurosurgery. 2008;63(2):212–7. discussion 217–218.

    Article  PubMed  Google Scholar 

  31. Badjatia N, Fernandez L, Schmidt JM, et al. Impact of induced normothermia on outcome after subarachnoid hemorrhage: a case-control study. Neurosurgery. 2010;66(4):696–700. discussion 700-691.

    Article  PubMed  Google Scholar 

  32. Thompson HJ, Pinto-Martin J, Bullock MR. Neurogenic fever after traumatic brain injury: an epidemiological study. J Neurol Neurosurg Psychiatry. 2003;74(5):614–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Geffroy A, Bronchard R, Merckx P, et al. Severe traumatic head injury in adults: which patients are at risk of early hyperthermia? Intensive Care Med. 2004;30(5):785–90.

    Article  PubMed  Google Scholar 

  34. Li J, Jiang JY. Chinese Head Trauma Data Bank: effect of hyperthermia on the outcome of acute head trauma patients. J Neurotrauma. 2012;29(1):96–100.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Clifton GL. A review of clinical trials of hypothermia treatment for severe traumatic brain injury. Therapeut Hypothermia Temp Manag. 2011;1(3):143–9.

    Article  Google Scholar 

  36. Clifton GL, Miller ER, Choi SC, et al. Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med. 2001;344(8):556–63.

    Article  CAS  PubMed  Google Scholar 

  37. Clifton GL, Valadka A, Zygun D, et al. Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial. Lancet Neurol. 2011;10(2):131–9. This randomized trial of induced hypothermia for the management of intracranial hypertension in acute traumatic brain injury failed to show a benefit in mortality and outcome compared to standard care.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Andrews PJ, Sinclair HL, Rodriguez A, et al. Hypothermia for intracranial hypertension after traumatic brain injury. N Engl J Med. 2015;373(25):2403–12.

    Article  CAS  PubMed  Google Scholar 

  39. Stevens RD, Shoykhet M, Cadena R. Emergency neurological life support: intracranial hypertension and herniation. Neurocrit Care. 2015;23 Suppl 2:76–82.

    Article  CAS  Google Scholar 

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Correspondence to George A. Lopez MD, PhD.

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George A. Lopez is a consultant for Zoll.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Critical Care Neurology

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Lopez, G.A. Temperature Management in the Neurointensive Care Unit. Curr Treat Options Neurol 18, 12 (2016). https://doi.org/10.1007/s11940-016-0393-6

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