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Interactions Between Inflammatory Bowel Disease Drugs and Chemotherapy

  • Intractable Disease in the Elderly: When Conventional Therapy Fails (S Katz, Section Editor)
  • Published:
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Opinion statement

As new and effective novel therapies in inflammatory bowel disease (IBD) become available, patients are living longer with advancing age and are at increased risk for malignancy. The management of IBD and malignancy involves multiple combinations of chemotherapy agents and IBD drugs, with the potential for interactions between these therapies. Interactions may either potentiate the effectiveness of drug class or exacerbate their common side effects. In this review article, we present a guide on studied interactions between IBD therapies and chemotherapy agents, specifically those of colorectal cancer, breast cancer, non-Hodgkin’s lymphoma, and melanoma. The pharmacology and pharmocokinetics of each IBD drug will be discussed. Then, the IBD drug and chemotherapy interactions are summarized in table format. This guide will provide a quick reference to guide clinicians with this challenging management of two disease processes.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Medicine, New York University School of Medicine, 550 1st Avenue, New York, NY, USA

    Galen Leung M.D., Marianna Papademetriou M.D., Shannon Chang M.D. & Seymour Katz M.D., F.A.C.P

  2. Division of Hematology and Medical Oncology, Department of Medicine, New York University School of Medicine, New York, NY, USA

    Francis Arena M.D., F.A.C.P

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  1. Galen Leung M.D.
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Galen Leung, Marianna Papademetriou, and Shannon Chang declare that they have no conflict of interest.

Francis Arena has received Speaker's Bureau fees from Celgene, Amgen, Merck, Bayer and Alexion.

Seymour Katz has no conflict of interest.

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A special thank you to Dr. Gary Falk for taking the time to review this manuscript.

This article is part of the Topical Collection on Intractable Disease in the Elderly: When Conventional Therapy Fails

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Leung, G., Papademetriou, M., Chang, S. et al. Interactions Between Inflammatory Bowel Disease Drugs and Chemotherapy. Curr Treat Options Gastro 14, 507–534 (2016). https://doi.org/10.1007/s11938-016-0109-8

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