Opinion Statement
Esophageal dysphagia in the elderly is a common clinical problem. Achalasia is a disease in which there is loss of ganglion in the myenteric plexus of the lower esophageal sphincter resulting in incomplete relaxation of that muscle causing a functional obstruction to outflow. Treatment is aimed at reducing sphincter pressure allowing for gravity and the oral portion of the swallow to propel the bolus through the esophagus. Pneumatic dilatation, Heller myotomy (laparoscopic), and the newest procedure peroral endoscopic esophageal myotomy (POEM) are all reasonable options for effective treatment even in the elderly. The choice depends on the decision of the patient, subtype of achalasia, local expertise, and fitness for surgery. Patients over 45 with type 2 achalasia respond exceptionally well to pneumatic dilation, and we recommend consideration of this technique if expertise is available. POEM has achieved excellent short-term results and if local expertise exists, it should be strongly considered especially in patients with type 3 achalasia. Type 1 achalasia may respond slightly better to myotomy, either Heller or POEM. Proton pump inhibitors remain the treatment of choice for GERD and should not be avoided in the elderly for fear of adverse reactions. While none of the FDA warnings nor concern for chronic renal failure or dementia can be dismissed, much more research is needed before we accept that PPIs are truly causal. Surgery for GERD in patients over 65 is as effective as in the young and should be considered in appropriate candidates. Eosinophilic esophagitis, while not common in the elderly, frequently results in clinically important dysphagia. PPIs, topical oral steroids, and dietary interventions are all used individually and together to improve symptoms. PPIs remain first line and are required twice daily for at least 8 weeks as an initial trial. Dilation with either balloons or polyvinyl dilators are highly effective in patients with rings and focal strictures, can be performed safely, and limit the number of medications an elderly patient needs to take.
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References and Recommended Reading
Papers of particular interest, published recently, have been highlighted as: • Of importance
Siemens H, Trupe EH, Siebens A. ECRI Report: diagnosis and treatment of swallowing disorders in acute-care stroke patients. Evidence report/technology assessment. J Am Geriatr Soc. 1986;34(3):192–98.
Ren J, Shaker R, Kusano M, et al. Effect of aging on the secondary esophageal peristalsis: presbyesophagus revisited. Am J Physiol. 1995;268(5 Pt 1):G772–9.
DeVault KR. Presbyesophagus: a reappraisal. Curr Gastroenterol Rep. 2002;4(3):193–9.
Clouse RE, Abramson BK, Todorczuk JR. Achalasia in the elderly: effects of aging on clinical presentation and outcome. Dig Dis Sci. 1991;36:225–8.
Ravi K, Murray JA, Geno DM, Katzka DA. Achalasia and chronic opiate use: innocent bystanders or associated conditions? Dis Esophagus. 2016;29(1):15–21. As this class of medication is common abnormal manometry in the setting of opiates must be interpreted with caution.
Sung HY, Kim JS, Lee KS, et al. The prevalence and patterns of pharyngoesophageal dysmotility in patients with early stage Parkinson’s disease. Mov Disord. 2010;25(14):2361–8.
Castell JA, Johnston BT, Colcher A. Manometric abnormalities of the oesophagus in patients with Parkinson’s disease. Neurogastroenterol Motil. 2001;13(4):361–4.
Sandler RS, Bozymski EM, Orlando RC. Failure of clinical criteria to distinguish between primary achalasia and achalasia secondary to tumor. Dig Dis Sci. 1982;27:209–13.
Francis DL, Katzka DA. Achalasia: update on the disease and its treatment. Gastroenterology. 2010;139:369–74.
Kahrilas PJ, Boeckxstaens G. The spectrum of achalasia: lessons from studies of pathophysiology and high-resolution manometry. Gastroenterology. 2013;145:954–65. Excellent article discussing manometric and clinical findings in achalasia. Discussion of different subtypes and there clinical relevance.
Boeckxstaens G, Annese V, des Varannes BS. Pneumatic dilation versus laparoscopic Heller’s Myotomy for idiopathic Achalasia. N Engl J Med. 2011;364:1807–16.
Bechara R, Inoue H. POEM, the Prototypical “New NOTES” Procedure and First Successful NOTES Procedure. Gastro Endo Clinics 26(2):237–255.
Bechara R, Ikeda H, Onimaru M, et. Per Oral Endoscopic Myotomy 1000 cases later. Pearls, Pitfalls and Practical Considerations. Gastro Endo Clinics. doi:10.1016/j.gie.2016.03.1469.
Kumbhari V, Tieu AH, Onimaru M. Peroral endoscopic myotomy (POEM) vs laparoscopic Heller myotomy (LHM) for the treatment of Type III achalasia in 75 patients: a multicenter comparative study. Endosc Int Open. 2015;3(3):E195–201.
Jones EL, Meara MP, Schwartz JS. Gastroesophageal reflux symptoms do not correlate with objective pH testing after peroral endoscopic myotomy. Surg Endosc. 2016;30(3):947–52.
Familiari P, Greco S, Gigante G. Gastroesophageal reflux disease after peroral endoscopic myotomy: analysis of clinical, procedural and functional factors, associated with gastroesophageal reflux disease and esophagitis. Dig Endosc. 2016;28(1):33–41.
Annese V, Bassotti G, Coccia G, et al. A multicentre randomised study of intrasphincteric botulinum toxin in patients with oesophageal achalasia. GISMAD Achalasia Study Group. Gut. 2000;46:597–600.
Vaezi MF, Richter JE, Wilcox CM, et al. Botulinum toxin versus pneumatic dilatation in the treatment of achalasia: a randomised trial. Gut. 1999;44:231–9.
Pasricha PJ, Rai R, Ravich WJ, et al. Botulinum toxin for achalasia: long-term outcome and predictors of response. Gastroenterology. 1996;110:1410–5.
Rosemurgy A, Villadolid D, Thometz D, et al. Laparoscopic heller myotomy provides durable relief from achalasia and salvages failures after botox or dilation. Ann Surg. 2005;241:725–35.
Horgan S, Pellegrini CA. Botulinum toxin injections for achalasia symptoms. Am J Gastroenterol. 1999;94:300–1.
Fishman VM, Parkman HP, Schiano TD, Hills C. Symptomatic improvement in achalasia after botulinum toxin injection of the lower esophageal sphincter. Am J Gastroenterol. 1996;91:1724–30.
Jacobs J, Richter JE. Opening the bird’s beak: tips and tricks for effective pneumatic dilation for achalasia. AJG. 2016;111:157–8. Article reviewing techniques of this procedure for achalasia.
Fass R, Pulliam G, Johnson C, et al. Symptom severity and oesophageal chemosensitivity to acid in older and young patients with gastro-oesophageal reflux. Ageing. 2000;29:125–30.
Lee J, Anggiansha A, Anggiansah R, et al. Effects of age on the gastroesophageal junction, esophageal motility, and reflux disease. Clin Gastroenterol Hepatol. 2007;5:1392–8.
Gutschow CA, Leers JM, Schroder W, et al. Effect of aging on esophageal motility in patients with and without GERD. Ger Med Sci 2011;9:Doc22.
Attwood SE, Ell C, Galmiche JP, et al. Long-term safety of proton pump inhibitor therapy assessed under controlled, randomised clinical trial conditions: data from the SOPRAN and LOTUS studies. Aliment Pharmacol Ther. 2015;41:1162–74. Prospectively collected data on adverse events on PPI in the setting of a clinical trial. Outlines overall few sides effects of this very safe drug class.
Janarthanan S, Ditah I, Adler DG, et al. Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: a meta-analysis. Am J Gastroenterol. 2012;107:1001–10.
McDonald EG, Milligan J, Frenette C, et al. Continuous proton pump inhibitor therapy and the associated risk of recurrent Clostridium difficile infection. JAMA Intern Med. 2015;175:784–91.
FDA Drug Safety Communication. Possible increased risk of fractures of the hip, wrist, and spine with the use of proton pump inhibitors. Washington, DC: US. Food and Drug Administration; 2011. Accesible en: http://www.fda.gov/Drugs/DrugSafety/ucm213206.htm.
Lambert AA, Lam JO, Paik JJ, et al. Risk of community-acquired pneumonia with outpatient proton-pump inhibitor therapy: a systematic review and meta-analysis. PLoS One. 2015;10, e0128004. doi:10.1371/journal.pone.0128004.
FDA Drug Safety Communication. Clostridium difficile-associated diarrhea can be associated with stomach acid drugs known as proton pump inhibitors (PPIs). Washington, DC: US. Food and Drug Admin-istration; 2012. Accesible en: http://www.fda.gov/Drugs/DrugSafety/ucm290510.htm.
Bhatt DL, Cryer BL, Contant CF, et al. Clopidogrel with or without omeprazole in coronary artery disease. N Engl J Med. 2010;363:1909–17.
O’Donoghue ML, Braunwald E, Antman EM, et al. Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials. Lancet. 2009;374:989–97.
Dellon ES, Gonsalves N, Hirano I. ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and esoniphilic esophagitis (EoE). AJG. 2013;108:679–92. Comprehensive document providing complete evidenced based guidelines for management of patients with eosinophilic esophagitis.
Muller S, Puhl S, Vieth M, et al. Analysis of symptoms and endoscopic findings in 117 patients with histological diagnoses of eosinophilic esophagitis. Endoscopy. 2007;39:339–44.
Gonsalves N, Policarpio-Nicolas M, Zhang Q, et al. Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis. Gastrointest Endosc. 2006;64:313–9.
Rodrigo S, Abboud G, Oh D. High intraepithelial eosinophil counts in esophageal squamous epithelium are not specific for eosinophilic esophagitis in adults. Am J Gastroenterol. 2008;103(2):435–42.
Murali AR, Gupta A, Attar BM, Ravi V. Topical steroids in eosinophilic esophagitis: systematic review and meta-analysis of placebo-controlled randomized clinical trials. J Gastroenterol Hepatol. 2016;31(6):1111–9. Excellent review of steroid effectiveness in EoE.
Kavitt RT, Hirano I, Vaezi MF. Diagnosis and treatment of eosinophilic esophagitis in adults. Am J Med. 4, 2016. doi: 10.1016/j.amjmed.2016.04.024.
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Felice Schnoll-Sussman declares no conflict of interest.
Philip O. Katz has received consultancy fees from Pfizer Consumer Health and Torax.
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This article is part of the Topical Collection on Intractable Disease in the Elderly: When Conventional Therapy Fails
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Schnoll-Sussman, F., Katz, P.O. Managing Esophageal Dysphagia in the Elderly. Curr Treat Options Gastro 14, 315–326 (2016). https://doi.org/10.1007/s11938-016-0102-2
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DOI: https://doi.org/10.1007/s11938-016-0102-2