Opinion statement
Alcoholic hepatitis is a common clinical problem confronting gastroenterologists and hepatologists alike. The fundamental issue regarding treatment of this disease is its recognition on the part of the physician. Chronic alcohol abuse, fever, leukocytosis, jaundice, and encephalopathy are key symptoms and signs that should prompt consideration of this diagnosis. Nutrition and abstinence from alcohol are the cornerstones of therapy. In addition, management of seriously ill, hospitalized patients should include prophylaxis for withdrawal and delirium tremens. Alcoholic hepatitis (AH) induces a profound catabolic state, resulting in net negative nitrogen balance. In part, because of malnutrition, AH carries a considerably high mortality rate. Therefore, nutrition remains a key aspect of therapy. In the absence of encephalopathy and in the presence of a functioning gastrointestinal tract, oral intake or nasogastric feedings should be given. If the gastrointestinal tract cannot be used (ie, because of paralytic ileus), then total parenteral nutrition is absolutely essential for recovery. A select subset of patients, based on multiple clinical trials and several meta-analyses, can be treated with corticosteroids provided that the patient does not have active gastrointestinal bleeding and does not have an active infection. The subset of patients with AH who should receive corticosteroids is based on calculation of a modified Maddrey discriminant function, which incorporates the patient’s prothrombin time and total serum bilirubin as variables in this equation. Generally, a 4-week course of prednisone or prednisolone is administered. D-penicillamine, colchicine, anabolic steroids, propylthiouracil, and antioxidants have not been shown to be effective in AH and cannot be recommended. After acute illness, patients should be discharged to an inpatient alcohol rehabilitation unit to ensure continued abstinence.
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References and Recommended Reading
Lucey MR: Issues in selection for and outcome of liver transplantation in patients with alcoholic liver disease. Liver Transpl Surg 1997, 3:227–230.
Maddrey WC: Alcohol-induced liver disease. Clin Liver Dis 2000, 4:115–131. Written by one of the foremost experts on alcoholic liver disease and an advocate of corticosteroid use in patients with AH. This review is by far the most recent and comprehensive guide on the subject.
Mendenhall CL: Alcoholic hepatitis. Clin Gastroenterol 1981, 10:417–441.
Mandel L, Hamele-Bena D: Alcoholic parotid sialadenosis. J Am Dent Assoc 1997, 128:1411–1415.
Frezza M, di Padova C, Pozzato G, et al.: High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. N Engl J Med 1990, 322:95–99.
Pares A, Caballeria J, Bruguera M, et al.: Histological course of alcoholic hepatitis. Influence of abstinence, sex, and extent of hepatic damage. J Hepatol 1986, 2:33–42.
Chedid A, Mendenhall CL, Gartside P, et al.: Prognostic factors in alcoholic liver disease. VA Cooperative Study Group. Am J Gastroenterol 1991, 86:210–216.
Sorbi D, Boynton J, Lindor KD: The ratio of aspartate aminotransferase to alanine aminotransferase: potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver disease. Am J Gastroenterol 1999, 94:1018–1022.
Menon KVN, Gores GJ, Shah VH: Pathogenesis, diagnosis, and treatment of alcoholic liver disease. Mayo Clin Proc 2001, 76:1021–1029. A comprehensive examination of the spectrum of alcoholic liver disease with focus on current research, pathophysiology, treatment, and future therapies.
Christensen E, Schlichting P, Fauerholdt L, et al.: Prognostic value of Child-Turcotte criteria in medically treated cirrhosis. Hepatology 1984, 4:430–435.
McCullough AJ, O’Connor JF: Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology. Am J Gastroenterol 1998, 93:2022–2036. This comprehensive review discusses controversies in the management of AH, including liver biopsy as a diagnostic tool as well as the use of corticosteroids in the treatment of AH.
Alexander JF, Lischner MW, Galambos JT: Natural history of alcoholic hepatitis, II: the long-term prognosis. Am J Gastroenterol 1971, 56:515–525.
Powell WJ, Klatskin G: Duration of survival in patients with Laennec’s cirrhosis: influence of alcohol withdrawal, and possible effects of recent changes in general management of the disease. Am J Med 1968, 44:406–420.
Mezey E, Caballeria J, Mitchell MC, et al.: Effect of parenteral amino acid supplementation on short-term and long-term outcomes in severe alcoholic hepatitis. A randomized controlled trial. Hepatology 1991, 14:1090–1096.
Calvey H, Davis M, Williams R: Controlled trial of nutritional supplementation, with and without branched chain amino acid enrichment, in treatment of acute alcoholic hepatitis. J Hepatol 1985, 1:141–151.
Imperiale TF, McCullough AJ: Do corticosteroids reduce mortality from alcoholic hepatitis? A metaanalysis of the randomized trials. Ann Intern Med 1990, 113:299–307.
Christensen E, Gluud C: Glucocorticoids are ineffective in alcoholic hepatitis: a meta-analysis adjusting for confounding variables. Gut 1995, 37:113–118.
Maddrey WC, Boitnott JK, Bedine MS, et al.: Corticosteroid therapy of alcoholic hepatitis. Gastroenterology 1978, 75:193–199.
Carithers RL, Herlong HF, Diehl AM, et al.: Methylprednisolone therapy in patients with severe alcoholic hepatitis: a randomized multicenter trial. Ann Intern Med 1989, 110:685–690.
Mendenhall CL, Anderson S, Garcia-Pont P, et al.: Shortterm and long-term survival in patients with alcoholic hepatitis treated with oxandrolone and prednisolone. N Engl J Med 1984, 311:1464–1470.
Mathurin P, Duchatelle V, Ramond MJ, et al.: Survival and prognostic factors in patients with severe alcoholic hepatitis treated with prednisolone. Gastroenterology 1996, 110:1847–1853.
Halle P, Pare P, Kaptein E, et al.: Double-blind, controlled trial of propylthiouracil in patients with severe acute alcoholic hepatitis. Gastroenterology 1982, 82:925–931.
Orrego H, Blake JE, Blendis LM: Long-term treatment of alcoholic liver disease with propylthiouracil: part 2. Influence of dropout rates and of continued alcohol consumption in a clinical trial. J Hepatol 1994, 20:343–349.
Batey RG: Alcohol-related liver disease: treatment controversies. Alcohol Alcohol Suppl 1994, 2:327–333.
Akriviadis EA, Steindel H, Pinto PC, et al.: Failure of colchicine to improve short-term survival in patients with alcoholic hepatitis. Gastroenterology 1990, 99:811–818.
Mendenhall C, Roselle GA, Gartside P, Moritz T: Relationship of protein calorie malnutrition to alcoholic liver disease: a reexamination of data from two Veterans Administration Cooperative Studies. Alcohol Clin Exp Res 1995, 19:635–641.
Mendenhall CL, Moritz TE, Roselle GA, et al.: A study of oral nutritional support with oxandrolone in malnourished patients with alcoholic hepatitis: results of a Department of Veterans Affairs cooperative study. Hepatology 1993, 17:564–576.
Diehl AM, Tietjen TG: Alcoholic liver disease. In Current Therapy in Gastroenterology and Liver Disease, edn 4. Edited by Bayless TM. Baltimore: Mosby; 1994:528–533.
Bird GL, Prach AT, McMahon AD, et al.: Randomized controlled double-blind trial of the calcium channel antagonist amlodipine in the treatment of acute alcoholic hepatitis. J Hepatol 1998, 28:194–198. This study reveals that calcium channel blockers are well tolerated but there is no conclusive evidence that they are helpful in the treatment of AH.
Bui Han SH: Alcoholic hepatitis. Curr Treat Options Gastroenterol 2001, 4:511–516. The previous review on AH in this journal notes that orthotopic liver transplantation is highly controversial for AH and that extracorporeal liver support devices are not widely available or necessarily effective. The same holds true now.
Achord JL: Review of alcoholic hepatitis and its treatment. Am J Gastroenterol 1993, 88:1822–1831.
McClain CJ, Barve S, Deaciuc I, Hill DB: Tumor necrosis factor and alcoholic liver disease. Alcohol Clin Exp Res 1998, 22:248S-252S.
Akriviadis E, Botla R, Briggs W, et al.: Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial. Gastroenterology 2000, 119:1637–1648. Pentoxifylline holds promise as a future therapy for AH.
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Crosse, K.I., Anania, F.A. Alcoholic hepatitis. Curr Treat Options Gastro 5, 417–423 (2002). https://doi.org/10.1007/s11938-002-0029-7
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DOI: https://doi.org/10.1007/s11938-002-0029-7