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Management of gastrointestinal bleeding in children

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Opinion statement

Gastrointestinal bleeding in infants and children is a potentially life-threatening problem that is encountered by virtually all practicing pediatric gastroenterologists. Youngsters with a normal hematocrit, hemodynamic stability, and a history consistent with an acute, self-limited illness most frequently need only close observation; others require more in-depth assessment and intervention. Meticulous attention to the patient’s cardiopulmonary status and knowledge of appropriate pediatric resuscitation schemes form the cornerstones on which more specific therapeutic interventions are based. Many treatment techniques and approaches have been extrapolated for pediatric use from adult studies; the regimen implemented for a child should be individualized and based on factors such as patient size, underlying condition, and operator expertise. Although the physician treating pediatric gastrointestinal hemorrhage requires more than a modicum of patience and determination, this must be tempered with a ready willingness to seek consultation from surgical colleagues to ensure optimal outcomes. Knowledge of acid-suppressive and vasoactive medications is essential, as is familiarity with at least one injection technique and one thermocoagulation technique for hemostasis. Endoscopic sclerotherapy and variceal band ligation are equally efficacious in achieving control of acute variceal bleeding, but band ligation is emerging as the technique best suited for prophylaxis. Beta blockade appears to have a smaller and less well-defined role in pediatric variceal prophylaxis compared with that in adults, but random controlled trials are necessary to confirm this impression.

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References and Recommended Reading

  1. Fox VL: Gastrointestinal bleeding in infancy and childhood. Gastroenterol Clin North Am 2000, 29:37–66. An excellent overview of the causes and the treatment approaches to pediatric GIB.

    Article  PubMed  CAS  Google Scholar 

  2. Heitlinger LA, McClung HJ: Gastrointestinal hemorrhage. In Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis, Management, edn 2. Edited by Wyllie R, Hyams JS. Philadelphia: WB Saunders Co.; 1999:64–72.

    Google Scholar 

  3. Chaibou M, Tucci M, Dugas MA, et al.: Clinically significant upper gastrointestinal bleeding acquired in a pediatric intensive care unit: a prospective study. Pediatrics 1998, 102:933–938.

    Article  PubMed  CAS  Google Scholar 

  4. Teach SJ, Fleisher GR: Rectal bleeding in the pediatric emergency department. Ann Emerg Med 1994, 23:1252–1254.

    PubMed  CAS  Google Scholar 

  5. Rayhorn N, Thrall C, Silber G: A review of the causes of upper gastrointestinal tract bleeding in children. Gastroenterol Nursing 2001, 24:23–27.

    Article  CAS  Google Scholar 

  6. Rayhorn N, Thrall C, Silber G: A review of the causes of lower gastrointestinal tract bleeding in children. Gastroenterol Nursing 2001, 24:77–82.

    Article  CAS  Google Scholar 

  7. Katon R: Complications of upper gastrointestinal endoscopy in the gastrointestinal bleeder. Dig Dis Sci 1981, 26:47S-54S.

    Article  PubMed  CAS  Google Scholar 

  8. Chameides L, Hazinski MF, eds: Textbook of Pediatric Advanced Life Support. Dallas: American Heart Association; 1994:1–10.

    Google Scholar 

  9. Olson AD, Hillemeier AC: Gastrointestinal hemorrhage. In Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis, Management. Edited by Wyllie R, Hyams JS. Philadelphia: WB Saunders Co.; 1993:251–270.

    Google Scholar 

  10. Garcia-Tsao G: Current management of the complications of cirrhosis and portal hypertension: variceal hemorrhage, ascites, and spontaneous bacterial peritonitis. Gastroenterology 2001, 120:726–748. A superb review of the most difficult dilemmas encountered in caring for patients with end-stage liver disease.

    Article  PubMed  CAS  Google Scholar 

  11. Kravetz D, Sikuler E, Groszman RJ: Splanchnic and systemic hemodynamics in portal hypertensive rats during hemorrhage and blood volume restitution. Gastroenterology 1986, 90:1232–1240.

    PubMed  CAS  Google Scholar 

  12. Luk G, Bynum T, Hendrix T: Gastric aspiration in localization of gastrointestinal hemorrhage. JAMA 1979, 241:576–578.

    Article  PubMed  CAS  Google Scholar 

  13. Rimada A, Garcia-Tsao G, Navasa M, et al.: Diagnosis, treatment, and prophylaxis of spontaneous bacterial peritonitis: a consensus document. J Hepatol 2000, 32:142–153.

    Google Scholar 

  14. Goulis J, Armonis A, Patch D, et al.: Bacterial infection is independently associated with failure to control bleeding in cirrhotic patients with gastrointestinal hemorrhage. Hepatology 1998, 27:1207–1212.

    Article  PubMed  CAS  Google Scholar 

  15. Bernard B, Grange JD, Khac EN, et al.: Antibiotic prophylaxis for the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding: a meta-analysis. Hepatology 1999, 29:1655–1661.

    Article  PubMed  CAS  Google Scholar 

  16. Felisart J, Rimola A, Arroyo V, et al.: Cefotaxime is more effective than is ampicillin-tobramycin in cirrhotics with severe infections. Hepatology 1985, 5:457–462.

    Article  PubMed  CAS  Google Scholar 

  17. Bajjoka AE: Ranitidine-induced thrombocytopenia. Arch Intern Med 1991, 151:203.

    Article  PubMed  CAS  Google Scholar 

  18. Oymak O, Akpolat T, Arik N, et al.: Reversible neutropenia and thrombocytopenia during famotidine treatment. Ann Pharmacother 1994, 28:406–407.

    PubMed  CAS  Google Scholar 

  19. Siberry GK, Iannone R, eds: The Harriet Lane Handbook edn 15. St. Louis: Mosby; 2000.

    Google Scholar 

  20. Heiselman DE, Horlisz DT, Fricker R, et al.: Randomized comparison of gastric pH control with intermittent and continuous infusion of famotidine in ICU patients. Am J Gastroenterol 1995, 90:277–279.

    PubMed  CAS  Google Scholar 

  21. Lau JYW, Sung JJY, Lee KK, et al.: Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcer. N Engl J Med 2000, 343:310–316.

    Article  PubMed  CAS  Google Scholar 

  22. McKiernan PJ: Treatment of variceal bleeding. Gastrointest Endosc Clin North Am 2001, 11:789–812. Outstanding and comprehensive review of an overlooked topic in pediatric gastroenterology.

    CAS  Google Scholar 

  23. Bosch J, Teres J: Immediate management of variceal hemorrhage: pharmacologic measures and balloon tamponade. Gastrointest Endosc Clin North Am 1992, 2:43–58.

    Google Scholar 

  24. Escorsell A, Bandi JC, Andreu V, et al.: Desensitization to the effects of intravenous octreotide in cirrhotic patients with portal hypertension. Gastroenterology 2001, 120:161–169.

    Article  PubMed  CAS  Google Scholar 

  25. Wyllie R, Kay MH: Therapeutic intervention for nonvariceal gastrointestinal hemorrhage. J Pediatr Gastroenterol Nutr 1996, 22:123–133. An excellent review of equipment, medications, and techniques used in management of nonvariceal pediatric GIB.

    Article  PubMed  CAS  Google Scholar 

  26. Richter JM, Christensen MR, Kaplan LM, et al.: Effectiveness of current technology in the diagnosis and management of lower gastrointestinal hemorrhage. Gastrointest Endosc 1995, 41:93–98.

    Article  PubMed  CAS  Google Scholar 

  27. Sugawa C: Endoscopic diagnosis and treatment of upper gastrointestinal bleeding. Surg Clin North Am 1989, 69:1167–1183.

    PubMed  CAS  Google Scholar 

  28. Goncalves ME, Cardoso SR, Maksoud JG: Prophylactic sclerotherapy in children with esophageal varices: long-term results of a controlled prospective randomized trial. J Pediatr Surg 2000, 35:401–405.

    Article  PubMed  CAS  Google Scholar 

  29. Grund KE, Straub T, Farin G: New haemostatic techniques: argon plasma coagulation. Baillieres Best Pract Res Clin Gastroenterol 1999, 13:67–84.

    Article  PubMed  CAS  Google Scholar 

  30. Wyllie R, Kay M: Esophagogastroduodensocopy, colonoscopy, and related techniques. In Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis, Management. Edited by Wyllie R, Hyams JS. Philadelphia: WB Saunders Co.; 1993:967–98.

    Google Scholar 

  31. Stevens PD, Lebwhol O: Hypertensive emergency and ventricular tachycardia after endoscopic epinephrine injection of a Mallory-Weiss tear. Gastrointest Endosc 1994, 40:77–78.

    Article  PubMed  CAS  Google Scholar 

  32. Hirao M, Kobayashi T, Masuda K, et al.: Endoscopic local injection of hypertonic saline-epinephrine solution to arrest hemorrhage from the upper gastrointestinal tract. Gastrointest Endosc 1985, 31:313–317.

    Article  PubMed  CAS  Google Scholar 

  33. Loperfido S, Patelli G, LaTorre L: Extensive necrosis of gastric mucosa following injection therapy of bleeding peptic ulcer. Endoscopy 1990, 22:285–86.

    PubMed  CAS  Google Scholar 

  34. Cotton PB, Williams CB: Practical Gastrointestinal Endoscopy, edn 4. Oxford: Blackwell Science Ltd; 1996.

    Google Scholar 

  35. Laine L: Determination of optimal technique for bipolar electrocoagulation treatment. Gastroenterology 1991, 100:107–112.

    PubMed  CAS  Google Scholar 

  36. Laine L: Bipolar/multipolar electrocoagulation. Gastrointest Endosc 1990, 36:538–541.

    Google Scholar 

  37. Rex DK, Lewis BS, Waye JD: Colonoscopy and endoscopic therapy for delayed post polypectomy hemorrhage. Gastrointest Endosc 1992, 38:127–129.

    PubMed  CAS  Google Scholar 

  38. Noronha PA, Leist MH: Endoscopic laser therapy for gastrointestinal bleeding from congenital vascular lesions. J Pediatr Gastroenterol Nutr 1988, 7:375–378.

    Article  PubMed  CAS  Google Scholar 

  39. Kendrick ML, Buttar NS, Anderson MA, et al.: Intraoperative enteroscopy in management of obscure gastrointestinal bleeding. J Gastrointestinal Surg 2001, 5:162–167.

    Article  CAS  Google Scholar 

  40. Lee KH, Yeung CK, Tam YH, et al.: Laparoscopy for definitive diagnosis and treatment of gastrointestinal bleeding of obscure origin in children. J Pediatr Surg 2000, 35:1291–1293.

    Article  PubMed  CAS  Google Scholar 

  41. Hassall E, Israel D: Portal hypertension. In Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis, Management. Edited by Wyllie R, Hyams JS. Philadelphia: WB Saunders Co.; 1993:370–390.

    Google Scholar 

  42. Sharara AI, Rockey DC: Gastroesophageal variceal hemorrhage. N Engl J Med 2001, 345:669–681. Wonderful review of variceal management from the adult perspective.

    Article  PubMed  CAS  Google Scholar 

  43. Grace ND, Groszman RJ, Garcia-Tsao G, et al.: Portal hypertension and variceal bleeding: an AASLD single topic symposium. Hepatology 1998, 28:868–880.

    Article  PubMed  CAS  Google Scholar 

  44. deFranchis R, Primignani M, Cosentino F: Endoscopic diagnosis and classification of varices. Gastrointestinal Endosc Clin North Am 1992, 2:17–30.

    Google Scholar 

  45. Ohi R, Mochizuki I, Komatsu K, et al.: Portal hypertension after successful hepatic portoenterostomy in biliary atresia. J Pediatr Surg 1986, 21:271–274.

    PubMed  CAS  Google Scholar 

  46. Bernard O, Alvarez F, Brunelle F, et al.: Portal hypertension in children. Clin Gastroenterol 1985, 14:33–35.

    PubMed  CAS  Google Scholar 

  47. Shashidhar H, Langhans N, Grand RJ: Propranolol in prevention of portal hypertensive hemorrhage in children: a pilot study. J Pediatr Gastroenterol Nutr 1999, 29:12–17.

    Article  PubMed  CAS  Google Scholar 

  48. Ozsoylu S, Kocak N, Demir H, et al.: Propranolol for primary and secondary prophylaxis of variceal bleeding in children with cirrhosis. Turk J Pediatr 2000, 42:31–33.

    PubMed  CAS  Google Scholar 

  49. Angelico M, Carli L, Piat C, et al.: Effects of isosorbide-5-mononitrate compared with propranolol on first bleeding and long-term survival in cirrhosis. Gastroenterology 1997, 113:1632–1639.

    Article  PubMed  CAS  Google Scholar 

  50. Besson I, Ingrand P, Person B, et al.: Sclerotherapy with or without octreotide for acute variceal bleeding. N Engl J Med 1995, 333:555–560.

    Article  PubMed  CAS  Google Scholar 

  51. Sokal EM, Van Hoorebeck N, Van Obbergh L, et al.: Upper gastrointestinal tract bleeding in cirrhotic children candidates for liver transplantation. Eur J Pediatr 1992, 151:326–328.

    Article  PubMed  CAS  Google Scholar 

  52. Pashankar D, Jamieson DH, Israel DM: Downhill esophageal varices. J Pediatr Gastroenterol Nutr 1999, 29:360–362.

    Article  PubMed  CAS  Google Scholar 

  53. Ohnuma N, Takahashi H, Tanabe M, et al.: Endoscopic variceal ligation using a clipping apparatus in children with portal hypertension. Endoscopy 1997, 29:86–90.

    PubMed  CAS  Google Scholar 

  54. Williams SG, Peters JA, Westaby D: Thrombin—an effective treatment for gastric variceal haemorrhage. Gut 1994, 35:1287–1289.

    PubMed  CAS  Google Scholar 

  55. Stockwell JA, Werner HA, Marsano LS: Dieulafoy’s lesion in an infant: a rare cause of massive gastrointestinal bleeding. J Pediatr Gastroenterol Nutr 2000, 31:68–70.

    Article  PubMed  CAS  Google Scholar 

  56. Gonzalez D, Elizondo BJ, Haslag S, et al.: Chronic subcutaneous octreotide decreases gastrointestinal blood loss in blue rubber-bleb nevus syndrome. J Pediatr Gastroenterol Nutr 2001, 33:183–188.

    Article  PubMed  CAS  Google Scholar 

  57. Zellos A, Schwarz KB: Efficacy of octreotide in children with chronic gastrointestinal bleeding. J Pediatr Gastroenterol Nutr 2000, 30:442–446.

    Article  PubMed  CAS  Google Scholar 

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Peters, J.M. Management of gastrointestinal bleeding in children. Curr Treat Options Gastro 5, 399–413 (2002). https://doi.org/10.1007/s11938-002-0028-8

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