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Chronic prostatitis/chronic pelvic pain syndrome and interstitial cystitis: Are they related?

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Abstract

Interstitial cystitis and chronic prostatitis/chronic pelvic pain syndrome are clinical syndromes characterized by pelvic pain with or without voiding symptoms such as urgency and frequency. There are many similarities in their epidemiology, adverse effect on quality of life, etiology/pathophysiology, natural history, and response to similar treatments. However, overlapping clinical definitions and similar entrance criteria for large-scale cohort studies make comparisons problematic. Newer efforts to classify pelvic pain syndromes should help in our recognition that interstitial cystitis and chronic prostatitis/chronic pelvic pain syndrome likely are not organ-specific syndromes but urogenital manifestations of regional or systemic abnormalities.

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References and Recommended Reading

  1. Curhan GC, Speizer FE, Hunter DJ, et al.: Epidemiology of interstitial cystitis: a population based study [see comment]. J Urol 1999, 161:549–552.

    Article  PubMed  CAS  Google Scholar 

  2. Clemens JQ, Meenan RT, O’Keeffe Rosetti MC, et al.:Prevalence of interstitial cystitis symptoms in a managed care population. J Urol 2005, 174:576–580.

    Article  PubMed  Google Scholar 

  3. O’Leary MP, Sant GR, Fowler FJ Jr, et al.: The interstitial cystitis symptom index and problem index. Urology 1997, 49:58–63.

    Article  PubMed  CAS  Google Scholar 

  4. Nickel JC, Teichman JM, Gregoire M, et al.: Prevalence, diagnosis, characterization, and treatment of prostatitis, interstitial cystitis, and epididymitis in outpatient urological practice: the Canadian PIE Study. Urology 2005, 66:935–940.

    Article  PubMed  Google Scholar 

  5. Litwin MS, McNaughton-Collins M, Fowler FJ Jr, et al.:The National Institutes of Health Chronic Prostatitis Symptom Index: development and validation of a new outcome measure. Chronic Prostatitis Collaborative Research Network. J Urol 1999, 162:369–375.

    Article  PubMed  CAS  Google Scholar 

  6. Nickel JC, Siemens DR, Nickel KR, Downey J: The patient with chronic epididymitis: characterization of an enigmatic syndrome [see comment]. J Urol 2002, 167:1701–1704.

    Article  PubMed  Google Scholar 

  7. Nickel JC, Downey J, Hunter D, Clark J: Prevalence of prostatitis-like symptoms in a population based study using the National Institutes of Health Chronic Prostatitis Symptom Index. J Urol 2001, 165:842–845.

    Article  PubMed  CAS  Google Scholar 

  8. Roberts RO, Jacobson DJ, Girman CJ, et al.: Prevalence of prostatitis-like symptoms in a community-based cohort of older men. J Urol 2002, 168:2467–2471.

    Article  PubMed  Google Scholar 

  9. Collins MM, Meigs JB, Barry MJ, et al.: Prevalence and correlates of prostatitis in the health professionals follow-up study cohort. J Urol 2002, 167:1363–1366.

    Article  PubMed  Google Scholar 

  10. Mehik A, Hellstrom P, Lukkarinen O, et al.: Epidemiology of prostatitis in Finnish men: a population-based crosssectional study. BJU Int 2000, 86:443–448.

    Article  PubMed  CAS  Google Scholar 

  11. Simon LJ, Landis JR, Erickson DR, Nyberg LM: The Interstitial Cystitis Data Base Study: concepts and preliminary baseline descriptive statistics. Urology 1997, 49:64–75.

    Article  PubMed  CAS  Google Scholar 

  12. Schaeffer AJ, Landis JR, Knauss JS, et al.: Demographic and clinical characteristics of men with chronic prostatitis: the National Institutes of Health Chronic Prostatitis Cohort Study [see comment]. J Urol 2002, 168:593–598.

    Article  PubMed  Google Scholar 

  13. Novi JM, Jeronis S, Srinivas S, et al.: Risk of irritable bowel syndrome and depression in women with interstitial cystitis: a case-control study. J Urol 2005, 174:937–940.

    Article  PubMed  Google Scholar 

  14. Weissman MM, Gross R, Fyer A, et al.: Interstitial cystitis and panic disorder: a potential genetic syndrome. Arch Gen Psychiatry 2004, 61:273–279.

    Article  PubMed  CAS  Google Scholar 

  15. Pontari MA, McNaughton-Collins M, O’Leary M P, et al.:A case-control study of risk factors in men with chronic pelvic pain syndrome. BJU Int 2005, 96:559–565.

    Article  PubMed  Google Scholar 

  16. Ware J Jr, Kosinski M, Keller SD: A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care 1996, 34:220–233.

    Article  PubMed  Google Scholar 

  17. Tincello DG, Walker AC: Interstitial cystitis in the UK: results of a questionnaire survey of members of the Interstitial Cystitis Support Group. Eur J Obstet Gynecol Reprod Biol 2005, 118:91–95.

    Article  PubMed  Google Scholar 

  18. McNaughton Collins M, Pontari MA, O’Leary MP, et al.:Quality of life is impaired in men with chronic prostatitis: the Chronic Prostatitis Collaborative Research Network [see comment]. J Gen Intern Med 2001, 16:656–662.

    Article  Google Scholar 

  19. Tripp DA, Curtis Nickel J, Landis JR, et al.: Predictors of quality of life and pain in chronic prostatitis/chronic pelvic pain syndrome: findings from the National Institutes of Health Chronic Prostatitis Cohort Study. BJU Int 2004, 94:1279–1282. This study examines the factors associated with decreased quality of life in men with CP/CPPS.

    Article  PubMed  Google Scholar 

  20. Lutgendorf SK, Latini JM, Rothrock N, et al.: Autonomic response to stress in interstitial cystitis. J Urol 2004, 172:227–231.

    Article  PubMed  Google Scholar 

  21. Ullrich PM, Turner JA, Ciol M, Berger R: Stress is associated with subsequent pain and disability among men with nonbacterial prostatitis/pelvic pain. Ann Behav Med 2005, 30:112–118.

    Article  PubMed  Google Scholar 

  22. Buffington CA: Comorbidity of interstitial cystitis with other unexplained clinical conditions. J Urol 2004, 172:1242–1248. This paper outlines the evidence for IC as an aberrant response to stress and reviews the probable biochemical pathways involved.

    Article  PubMed  Google Scholar 

  23. Pontari MA, Ruggieri MR: Mechanisms in prostatitis/ chronic pelvic pain syndrome. J Urol 2004, 172:839–845.

    Article  PubMed  Google Scholar 

  24. Fitzgerald MP, Koch D, Senka J: Visceral and cutaneous sensory testing in patients with painful bladder syndrome. Neurourol Urodyn 2005, 24:627–632.

    Article  PubMed  Google Scholar 

  25. Ness TJ, Powell-Boone T, Cannon R, et al.: Psychophysical evidence of hypersensitivity in subjects with interstitial cystitis. J Urol 2005, 173:1983–1987.

    Article  PubMed  Google Scholar 

  26. Yang CC, Lee JC, Kromm BG, et al.: Pain sensitization in male chronic pelvic pain syndrome: Why are symptoms so difficult to treat? J Urol 2003, 170:823–827.

    Article  PubMed  Google Scholar 

  27. Propert KJ, Schaeffer AJ, Brensinger CM, et al.: A prospective study of interstitial cystitis: results of longitudinal follow-up of the interstitial cystitis database cohort. The Interstitial Cystitis Database Study Group. J Urol 2000, 163:1434–1439.

    Article  PubMed  CAS  Google Scholar 

  28. Propert KJ, McNaughton-Collins M, Leiby B, et al.: A prospective study of symptoms and quality of life in men with chronic prostatitis/chronic pelvic pain syndrome: the National Institutes of Health Chronic Prostatitis Cohort Study. J Urol 2006, 175:619–623.

    Article  PubMed  Google Scholar 

  29. Warren JW, Horne LM, Hebel JR, et al.: Pilot study of sequential oral antibiotics for the treatment of interstitial cystitis. J Urol 2000, 163:1685–1688.

    Article  PubMed  CAS  Google Scholar 

  30. Alexander RB, Propert KJ, Schaeffer AJ, et al.: Ciprofioxacin or tamsulosin in men with chronic prostatitis/chronic pelvic pain syndrome: a randomized, double-blind trial. Ann Intern Med 2004, 141:581–589 (Summary for patients in Ann Intern Med 2004, 141:I8).

    PubMed  CAS  Google Scholar 

  31. Nickel JC, Forrest JB, Tomera K, et al.: Pentosan polysulfate sodium therapy for men with chronic pelvic pain syndrome: a multicenter, randomized, placebo-controlled study. J Urol 2005, 173:1252–1255.

    Article  PubMed  Google Scholar 

  32. Nickel JC, Barkin J, Forrest J, Mosbaugh PG, et al.: Randomized, double-blind, dose-ranging study of pentosan polysulfate sodium for interstitial cystitis. Urology 2005, 65:654–658.

    Article  PubMed  Google Scholar 

  33. Palapattu GS, Shoskes DA: Resolution of the chronic pelvic pain syndrome after renal transplantation. J Urol 2000, 164:127.

    Article  PubMed  CAS  Google Scholar 

  34. Sairanen J, Forsell T, Ruutu M: Long-term outcome of patients with interstitial cystitis treated with low-dose cyclosporine A. J Urol 2004, 171:2138–2141.

    Article  PubMed  CAS  Google Scholar 

  35. Keay S, Zhang CO, Marvel R, Chai T: Antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor: sensitive and specific urine markers for interstitial cystitis. Urology 2001, 57(supp l):104.

    Article  PubMed  CAS  Google Scholar 

  36. Keay S, Zhang CO, Shoenfelt JL, Chai TC: Decreased in vitro proliferation of bladder epithelial cells from patients with interstitial cystitis. Urology 2003, 61:1278–1284.

    Article  PubMed  Google Scholar 

  37. Keay S, Seillier-Moiseiwitsch F, Zhang CO, et al.: Changes in human bladder epithelial cell gene expression associated with interstitial cystitis or antiproliferative factor treatment. Physiol Genomics 2003, 14:107–115.

    PubMed  CAS  Google Scholar 

  38. Keay SK, Szekely Z, Conrads TP, et al.: An antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide. Proc Natl Acad Sci U S A 2004, 101:11803–11808. This important paper describes the chemical structure of APF, the most important biomarker described to date for IC.

    Article  PubMed  CAS  Google Scholar 

  39. Jones SE, Jomary C, Grist J, et al.: Modulated expression of secreted frizzled-related proteins in human retinal degeneration. Neuroreport 2000, 11:3963–3967.

    Article  PubMed  CAS  Google Scholar 

  40. Schumann H, Holtz J, Zerkowski HR, Hatzfeld M:Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis-related gene expression. Cardiovasc Res 2000, 45:720–728.

    Article  PubMed  CAS  Google Scholar 

  41. Keay S, Zhang CO, Chai T, et al.: Antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor in men with interstitial cystitis versus chronic pelvic pain syndrome. Urology 2004, 63:22–26.

    Article  PubMed  Google Scholar 

  42. Krieger JN, Nyberg L Jr, Nickel JC: NIH consensus definition and classification of prostatitis. JAMA 1999, 282:236–237.

    Article  PubMed  CAS  Google Scholar 

  43. Gillenwater JY, Wein AJ: Summary of the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases Workshop on Interstitial Cystitis, National Institutes of Health, Bethesda, Maryland, August 28–29, 1987. J Urol 1988, 140:203–206.

    PubMed  CAS  Google Scholar 

  44. Hanno PM, Landis JR, Matthews-Cook Y, et al.: The diagnosis of interstitial cystitis revisited: lessons learned from the National Institutes of Health Interstitial Cystitis Database study. J Urol 1999, 161:553–557.

    Article  PubMed  CAS  Google Scholar 

  45. Fall M, Baranowski AP, Fowler CJ, et al.: EAU guidelines on chronic pelvic pain. Eur Urol 2004, 46:681–689.

    Article  PubMed  CAS  Google Scholar 

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  1. Temple University School of Medicine, 3401 North Broad Street, 19140, Philadelphia, PA, USA

    Michel A. Pontari MD

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  1. Michel A. Pontari MD
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Correspondence to Michel A. Pontari MD.

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Pontari, M.A. Chronic prostatitis/chronic pelvic pain syndrome and interstitial cystitis: Are they related?. Curr Urol Rep 7, 329–334 (2006). https://doi.org/10.1007/s11934-996-0013-1

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  • DOI: https://doi.org/10.1007/s11934-996-0013-1

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