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Implications of the Genitourinary Microbiota in Prostatic Disease

  • Benign Prostatic Hyperplasia (K McVary, Section Editor)
  • Published:
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Abstract

Purpose of Review

To summarize recent investigation into associations between the genitourinary microbiota and prostatic disease.

Recent Findings

The genitourinary tract is not sterile. There are microbial communities (microbiota) in each niche of the genitourinary tract including the bladder, prostate, and urethra, which have been the subject of increasing scientific interest. Investigators have utilized several unique methods to study them, resulting in a highly heterogeneous body of literature. To characterize these genitourinary microbiota, diverse clinical specimens have been analyzed, including urine obtained by various techniques, seminal fluid, expressed prostatic secretions, and prostatic tissue. Recent studies have attempted to associate the microbiota detected from these samples with urologic disease and have implicated the genitourinary microbiota in many common conditions, including benign prostatic hyperplasia (BPH), prostate cancer, and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Summary

In this review, we summarize the recent literature pertaining to the genitourinary microbiota and its relationship to the pathophysiology and management of three common prostatic conditions: BPH, prostate cancer, and CP/CPPS.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Acknowledgments

We would like to thank the members of the Loyola Urinary Education and Research Collaborative (LUEREC) for their contributions to the work described.

Funding

AJW has been supported by National Institutes of Health grants R01 DK104718, 2 U10 HD41250, U01 DK58229, R21 DK097435, R56 DK104718, and P20 DK108268, a translational grant from the Falk Foundation, and by RFC LU206998 from Loyola University Chicago. AJW also has received funding for an Investigator Initiated Study VESI-12D01 from Astellas Scientific and Medical Affairs, Inc. AVF and LB have been supported by Loyola University Chicago RFC LU207906. LB has also been supported by the Interstitial Cystitis Association.

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  1. Department of Urology, Loyola University Chicago Stritch School of Medicine, 2160 South First Ave. Building 54, Room 23A, Maywood, IL, 60153, USA

    Petar Bajic, Ryan A. Dornbier, Chirag P. Doshi, Ahmer V. Farooq & Larissa Bresler

  2. Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine, 2160 South First Ave. CTRE Building, Room 224, Maywood, IL, 60153, USA

    Alan J. Wolfe

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  1. Petar Bajic
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Correspondence to Petar Bajic.

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Petar Bajic and Chirag P. Doshi each declare no potential conflicts of interest.

Ryan A. Dornbier, Ahmer V. Farooq, and Larissa Bresler report intramural funding from Loyola University Medical Center Research Committee.

Alan J. Wolfe reports grants from Astellas Scientific and Medical Affairs and Kimberly Clark Corporation.

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Bajic, P., Dornbier, R.A., Doshi, C.P. et al. Implications of the Genitourinary Microbiota in Prostatic Disease. Curr Urol Rep 20, 34 (2019). https://doi.org/10.1007/s11934-019-0904-6

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