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Adipose Tissue-Derived Stem Cells for the Treatment of Erectile Dysfunction

  • Regenerative Medicine (A Atala, Section Editor)
  • Published:
Current Urology Reports Aims and scope Submit manuscript

Abstract

Although a spectrum of options is available for erectile dysfunction (ED) treatment, ED in diabetics, post-prostatectomy patients, and those with Peyronie’s disease (PD) may be more severe in degree and less likely to respond to conventional medical therapies. Unfortunately, there have been limited breakthroughs in therapeutic options for severe ED during the past decade. However, one of the more fascinating strategies in preclinical development to treat ED is stem cell transplantation. Depending on the cell type, recent research has demonstrated that with transplantation, these stem cells can exert a paracrine effect on surrounding penile tissues and differentiate into smooth muscle, endothelium, and neurons. Adipose tissue-derived stem cells (ADSCs) have become a valuable resource because of their abundance and ease of isolation. It is evident that ADSCs may provide a realistic, therapeutic modality for the treatment of ED. In this review, we will cover the literature that has evaluated ADSCs in the treatment of ED.

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Author notes

    Authors and Affiliations

    1. School of Medicine, Department of Urology, Tulane University, New Orleans, LA, USA

      Ahmet Gokce, Taylor C. Peak, Asim B. Abdel-Mageed & Wayne J. Hellstrom

    2. School of Medicine, Department of Urology, Sakarya University, Sakarya, Turkey

      Ahmet Gokce

    3. Department of Urology, Tulane University Health Sciences Center, 1430 Tulane Ave. SL-42, New Orleans, LA, 70112, USA

      Wayne J. Hellstrom

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    1. Ahmet Gokce
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    2. Taylor C. Peak
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    Correspondence to Wayne J. Hellstrom.

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    Conflict of Interest

    Ahmet Gokce, Taylor C. Peak, and Asim B. Abdel-Mageed each declare no potential conflicts of interest.

    Wayne J Hellstrom reports support from from Abbvie, Allergan, AMS, Antares, Coloplast, Endo, Pfizer, Repros, Lipocine, NERI, and Menarini, and non-financial support from NIH and Theralogix.

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    This article does not contain any studies with human or animal subjects performed by any of the authors.

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    This article is part of the Topical Collection on Regenerative Medicine

    Ahmet Gokce and Taylor C. Peak contributed equally to this work.

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    Gokce, A., Peak, T.C., Abdel-Mageed, A.B. et al. Adipose Tissue-Derived Stem Cells for the Treatment of Erectile Dysfunction. Curr Urol Rep 17, 14 (2016). https://doi.org/10.1007/s11934-015-0569-8

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    • DOI: https://doi.org/10.1007/s11934-015-0569-8

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