Abstract
Current research in prostate brachytherapy focuses on five key concepts covered in this review. Transrectal ultrasound-guided prostate brachytherapy assisted by intraoperative treatment planning is the most advanced form of image-guided radiation delivery. Prostate brachytherapy alone for low-risk prostate cancer achieves lower prostate-specific antigen (PSA) nadirs than intensity-modulated radiotherapy (IMRT) or protons while maintaining durable biochemical control in about 90% of patients without late failures seen in surgically treated patients. As an organ-conserving treatment option, seed implant results in a lower rate of erectile dysfunction and urinary incontinence than surgery that has been validated in several recent prospective studies. Combined IMRT and seed implant has emerged as a rational and highly effective approach to radiation-dose escalation for intermediate- and high-risk prostate cancer. Preliminary results suggest that seed implantation may play a role in improving outcomes for historically poor-prognosis locally advanced and recurrent prostate cancers.
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Disclosures
Dr. J. A. Cesaretti: none. Johnny Kao has received grants or has grants pending from Pfizer and OSI Pharmaceuticals, and has received payment for the development of educational services from Sanofi-Aventis. Dr. Nelson Stone has served as a board member for Prologics LLC and the Prostate Cancer Education Council; has served as a consultant for Nihon Medi-Physics; and has received honoraria from Centocor, Diversified Conference Management, Ferring Pharmaceuticals, and Bayer. Dr. Richard Stock has received honoraria from Bard Pharmaceuticals and has received payment for the development of educational services from Diversified Conference Management.
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Kao, J., Cesaretti, J.A., Stone, N.N. et al. Update on Prostate Brachytherapy: Long-term Outcomes and Treatment-related Morbidity. Curr Urol Rep 12, 237–242 (2011). https://doi.org/10.1007/s11934-011-0183-3
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DOI: https://doi.org/10.1007/s11934-011-0183-3