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Female sexual dysfunction: State of the art

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Abstract

Female sexual dysfunction, a common, multifactorial, and often undertreated medical condition, attracted the attention of the medical community with the successful introduction of medical therapy for male erectile dysfunction. This review discusses the updated classification systems and definitions, epidemiologic aspects, and new pathophysiologic and therapeutic implications of this sexual disorder.

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References and Recommended Reading

  1. Basson R, Berman J, Burnett A, et al.: Report of the international consensus development conference on female sexual dysfunction: definitions and classifications. J Urol 2000, 163:888–893. This paper reports on the results from a multidisciplinary consensus conference that produced updated definitions and classifications of FSD.

    Article  PubMed  CAS  Google Scholar 

  2. Laumann EO, Paik A, Rosen RC: Sexual dysfunction in the United States: relevance and predictors. JAMA 1999, 281:537–544. A well-conducted, and still one of the most important epidemiologic studies on sexual dysfunction in the United States.

    Article  PubMed  CAS  Google Scholar 

  3. Berman JR, Goldstein I: Female sexual dysfunction. Urol Clin North Am 2001, 28:405–416.

    Article  PubMed  CAS  Google Scholar 

  4. Kaplan HS: The New Sex Therapy. New York: Brunner Mazel; 1974.

    Google Scholar 

  5. Masters WH, Johnson VE: Human Sexual Inadequacy. Boston: Little Brown; 1970.

    Google Scholar 

  6. Rosen RC: Prevalence and risk factors of sexual dysfunction in men and women. Curr Psychiatry Rep 2000, 2:189–195.

    Article  PubMed  CAS  Google Scholar 

  7. American Psychiatric Association: DSM-IV: Diagnostic and Statistical Manual of Mental Disorders, edn. 4. Washington, DC: American Psychiatric Press; 1994.

    Google Scholar 

  8. World Health Organization: ICD 10: International Statistical Classification of Diseases and Related Health Problems. Geneva; World Health Organization: 1992.

    Google Scholar 

  9. Basson R: The female sexual response: a different model. J Sex Marital Ther 2000, 26:51–65.

    Article  PubMed  CAS  Google Scholar 

  10. Berman JR, Bassuk J: Physiology and pathophysiology of female sexual function and dysfunction. World J Urol 2002, 20:111–118.

    Article  PubMed  Google Scholar 

  11. Goldstein I, Berman JR: Vasculogenic female sexual dysfunction: vaginal engorgement and clitoral erectile insufficiency syndromes. Int J Impot Res 1998, 10(Suppl 2):S84-S90.

    PubMed  Google Scholar 

  12. Berman JR, Berman L, Goldstein I: Female sexual dysfunction: incidence, pathophysiology, evaluation, and treatment options. Urology 1999, 54:385–391.

    Article  PubMed  CAS  Google Scholar 

  13. Sipski ML, Rosen RC, Alexander CJ, et al.: Sildenafil effects on sexual and cardiovascular responses in women with spinal cord injury. Urology 2000, 55:812–815.

    Article  PubMed  CAS  Google Scholar 

  14. Dundar M, Kocak I, Erkus M, et al.: The effect of estrogenreplacement therapy on clitoral-cavernosal tissue in oophorectomized rats: a histo-quantitative study by image analyzer. Urol Res 2001, 29:317–320.

    Article  PubMed  CAS  Google Scholar 

  15. Shafik A: The role of the levator ani muscle in evacuation, sexual performance and pelvic floor disorders. Int Urogynecol J Pelvic Floor Dysfunct 2000, 11:361–376.

    Article  PubMed  CAS  Google Scholar 

  16. Rosen RC, Lane RM, Menza M: Effects of SSRIs on sexual function: a critical review. J Clin Psychopharmacol 1999, 19:67–85.

    Article  PubMed  CAS  Google Scholar 

  17. Coleman CC, King BR, Bolden-Watson C, et al.: A placebocontrolled comparison of the effects on sexual functioning of bupropion sustained release and fluoxetine. Clin Ther 2001, 23:1040–1058.

    Article  PubMed  CAS  Google Scholar 

  18. Rosen RC, Leiblum SR: Treatment of sexual disorders in the 1990s: an integrated approach. J Consult Clin Psychol 1995, 63:877–890.

    Article  PubMed  CAS  Google Scholar 

  19. Burchardt M, Burchardt T, Anastasiadis AG, et al.: Sexual dysfunction is common and overlooked in female patients with hypertension. J Sex Marital Ther 2002, 28:17–26.

    Article  PubMed  Google Scholar 

  20. Stuart FM, Hammond DC, Pett MA: Inhibited sexual desire in women. Arch Sex Behav 1987, 16:91–106.

    Article  PubMed  CAS  Google Scholar 

  21. Dunn KM, Croft PR, Hackett GI: Sexual problems: a study of the prevalence and need for health care in the general population. Fam Pract 1998, 15:519–524.

    Article  PubMed  CAS  Google Scholar 

  22. Rosen RC, Taylor JF, Leiblum SR, et al.: Prevalence of sexual dysfunction in women: results of a survey study of 329 women in an outpatient gynecological clinic. J Sex Marital Ther 1993, 19:171–188.

    PubMed  CAS  Google Scholar 

  23. Heimann JR, Grafton-Becker V: Orgasmic Disorders in Women. New York: Guidford Press; 1989.

    Google Scholar 

  24. Jamieson DJ, Steege JF: The prevalence of dysmenorrhea, dyspareunia, pelvic pain, and irritable bowel syndrome in primary care practices. Obstet Gynecol 1996, 87:55–58.

    Article  PubMed  CAS  Google Scholar 

  25. Shokrollahi P, Mirmohamadi M, Mehrabi F, et al.: Prevalence of sexual dysfunction in women seeking services at family planning centers in Tehran. J Sex Marital Ther 1999, 25:211–215.

    Article  PubMed  CAS  Google Scholar 

  26. Van Geelen JM, van de Weijer H, Arnolds H: Urogenital symptoms and their resulting discomfort in non-institutionalized 50-to-75-year-old Dutch women [in Dutch]. Ned Tijdschr Geneeskd 1996, 140:713–716.

    PubMed  Google Scholar 

  27. Stenberg A, Heimer G, Ulmsten U: The prevalence of urogenital symptoms in postmenopausal women. Maturitas 1995, 22(Suppl):S17-S20.

    Article  PubMed  Google Scholar 

  28. Spector IP, Carey MP: Incidence and prevalence of the sexual dysfunctions: a critical review. Arch Sex Behav 1990, 19:389–409.

    Article  PubMed  CAS  Google Scholar 

  29. Leiblum SR, Wiegel M: Psychotherapeutic interventions for treating female sexual dysfunction. World J Urol 2002, 20:127–136. This article is an extremely well-written review about sex therapy for FSD from one of the experts in the field.

    Article  PubMed  Google Scholar 

  30. Burnett AL, Calvin DC, Silver RI, et al.: Immunohistochemical description of nitric oxide synthase isoforms in human clitoris. J Urol 1997, 158:75–78.

    Article  PubMed  CAS  Google Scholar 

  31. Palle C, Bredjkaer HE, Ottesen B, et al.: Vasoactive intestinal polypeptide and human vaginal blood flow: comparison between transvaginal and intravenous administration. Clin Exp Pharmacol Physiol 1990, 17:61–68.

    PubMed  CAS  Google Scholar 

  32. Basson R: The complexities of female sexual arousal disorder: potential role of pharmacotherapy. World J Urol 2002, 20:119–126. This is an excellent update on pathophysiologic and therapeutic perspectives in FSD.

    Article  PubMed  Google Scholar 

  33. Sipski M, Rosen RC, Alexander CJ, et al.: Sildenafil effects on sexual and cardiovascular responses in women with spinal cord injury. Urology 2000, 55:812–815.

    Article  PubMed  CAS  Google Scholar 

  34. Caruso S, Intelisano G, Lupo L, Agnello C: Premenopausal women affected by sexual arousal disorder treated with sildenafil: a double-blind, cross-over, placebo-controlled study. BJOG 2001, 108:623–628.

    Article  PubMed  CAS  Google Scholar 

  35. Shen WW, Urosevich Z, Clayton DO: Sildenafil in the treatment of female sexual dysfunction induced by selective serotonin reuptake inhibitors. J Reprod Med 1999, 44:535–542.

    PubMed  CAS  Google Scholar 

  36. Hoyle CHV, Stones RW, Robson T, et al.: Innervation of vasculature and microvasculature of the human vagina by NOS and neuropeptide-containing nerves. J Anat 1996, 188:633–644.

    PubMed  Google Scholar 

  37. Davis SR: Androgens and female sexuality. J Gend Specif Med 2000, 3:36–40.

    PubMed  CAS  Google Scholar 

  38. Davis SR, Tran J: Testosterone influences libido and well being in women. Trends Endocrinol Metab 2001, 12:33–37. This overview provides important information about the role of testosterone and androgen therapy for FSD, including presentation of currently available compounds, side effects, and results of new studies.

    Article  PubMed  CAS  Google Scholar 

  39. Shifren JL, Braunstein GD, Simon JA, et al.: Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000, 343:682–688.

    Article  PubMed  CAS  Google Scholar 

  40. Tuiten A, Van Honk J, Koppeschaar H, et al.: Time course and effects of testosterone administration on sexual arousal in women. Arch Gen Psychiatry 2000, 57:149–153.

    Article  PubMed  CAS  Google Scholar 

  41. Arlt W, Callies F, Van Vlijmen JC, et al.: Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med 1999, 341:1013–1020.

    Article  PubMed  CAS  Google Scholar 

  42. Guay A, Davis SR: Testosterone insufficiency in women: fact or fiction? World J Urol 2002, 20:106–110. Another critical and important review of androgens and their role in FSD.

    Article  PubMed  CAS  Google Scholar 

  43. Billups KL: The role of mechanical devices in treating female sexual dysfunction and enhancing the female sexual response. World J Urol 2002, 20:137–141.

    Article  PubMed  Google Scholar 

  44. Hurlbert DF: The coital alignment technique and directed masturbation: a comparative study on female orgasm. J Sex Marital Ther 1995, 21:21–29.

    PubMed  CAS  Google Scholar 

  45. Wilson SK, Delk JR 2nd, Billups KL: Treating symptoms of female sexual arousal disorder with the Eros-Clitoral Therapy Device. J Gend Specif Med 2001, 4:54–58.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, College of Physicians and Surgeons of Columbia University, 161 Fort Washington Avenue, Herbert Irving Pavilion, 11th Floor, 10032, New York, NY, USA

    Ridwan Shabsigh MD

Authors
  1. Aristotelis G. Anastasiadis MD
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  2. Laurent Salomon MD
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  3. Mohamed A. Ghafar MD
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  4. Martin Burchardt MD
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  5. Ridwan Shabsigh MD
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Anastasiadis, A.G., Salomon, L., Ghafar, M.A. et al. Female sexual dysfunction: State of the art. Curr Urol Rep 3, 484–491 (2002). https://doi.org/10.1007/s11934-002-0102-8

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  • DOI: https://doi.org/10.1007/s11934-002-0102-8

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