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Prevention and Management of Cataracts in Children with Juvenile Idiopathic Arthritis–Associated Uveitis

  • PEDIATRIC RHEUMATOLOGY (TJA LEHMAN, SECTION EDITOR)
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Abstract

Juvenile idiopathic arthritis (JIA)-associated uveitis can be associated with vision-compromising complications such as cataracts, glaucoma, synechiae, and band keratopathy. Of these, cataracts are one of the most common sequelae of JIA-associated uveitis and can result in significant visual disability. Risk factors for cataracts include posterior synechiae and longstanding ocular inflammation. Prevention of cataract development is crucial through appropriate control of uveitis. However, not all preventive measures are successful, and further management consisting of medical and surgical techniques is often necessary. Various factors should be taken into consideration when deciding on cataract management, including timing of surgery and placement of an intraocular lens. Continued partnership between pediatric rheumatologists and pediatric ophthalmologists can help ensure favorable visual outcomes.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Kesen MR, Setlur V, Goldstein DA. Juvenile idiopathic arthritis-related uveitis. Int Ophthalmol Clin. 2008;48:21–38.

    Article  PubMed  Google Scholar 

  2. Kotaniemi K, Savolainen A, Karma A, Aho K. Recent advances in uveitis of juvenile idiopathic arthritis. Surv Ophthalmol. 2003;48:489–502.

    Article  PubMed  Google Scholar 

  3. Zierhut M, Michels H, Stubiger N, et al. Uveitis in children. Int Ophthalmol Clin. 2005;45:135–56.

    Article  PubMed  Google Scholar 

  4. Kotaniemi K, Kautiainen H, Karma A, Aho K. Occurrence of uveitis in recently diagnosed juvenile chronic arthritis: a prospective study. Ophthalmology. 2001;108:2071–5.

    Article  PubMed  CAS  Google Scholar 

  5. Kotaniemi K, Arkela-Kautiainen M, Haapasaari J, Leirisalo-Repo M. Uveitis in young adults with juvenile idiopathic arthritis: a clinical evaluation of 123 patients. Ann Rheum Dis. 2005;64:871–4.

    Article  PubMed  CAS  Google Scholar 

  6. Grassi A, Corona F, Casellato A, et al. Prevalence and outcome of juvenile idiopathic arthritis-associated uveitis and relation to articular disease. J Rheumatol. 2007;34:1139–45.

    PubMed  Google Scholar 

  7. Heiligenhaus A, Niewerth M, Ganser G, et al. Prevalence and complications of uveitis in juvenile idiopathic arthritis in a population-based nation-wide study in Germany: suggested modification of the current screening guidelines. Rheumatology (Oxford). 2007;46:1015–9.

    Article  CAS  Google Scholar 

  8. Skarin A, Elborgh R, Edlund E, Bengtsson-Stigmar E. Long-term follow-up of patients with uveitis associated with juvenile idiopathic arthritis: a cohort study. Ocular Immunology & Inflammation. [Article]. 2009;17:104-8.

    Google Scholar 

  9. Saurenmann RK, Levin AV, Feldman BM, et al. Prevalence, risk factors, and outcome of uveitis in juvenile idiopathic arthritis: a long-term followup study. Arthritis Rheum. 2007;56:647–57.

    Article  PubMed  CAS  Google Scholar 

  10. Sabri K, Saurenmann RK, Silverman ED, Levin AV. Course, complications, and outcome of juvenile arthritis-related uveitis. J AAPOS. 2008;12:539–45.

    Article  PubMed  Google Scholar 

  11. Chen CS, Roberton D, Hammerton ME. Juvenile arthritis-associated uveitis: visual outcomes and prognosis. Can J Ophthalmol. 2004;39:614–20.

    PubMed  Google Scholar 

  12. Oren B, Sehgal A, Simon JW, et al. The prevalence of uveitis in juvenile rheumatoid arthritis. J AAPOS. 2001;5:2–4.

    Article  PubMed  CAS  Google Scholar 

  13. Kotaniemi K, Kaipiainen-Seppanen O, Savolainen A, Karma A. A population-based study on uveitis in juvenile rheumatoid arthritis. Clin Exp Rheumatol. 1999;17:119–22.

    PubMed  CAS  Google Scholar 

  14. Chalom EC, Goldsmith DP, Koehler MA, et al. Prevalence and outcome of uveitis in a regional cohort of patients with juvenile rheumatoid arthritis. J Rheumatol. 1997;24:2031–4.

    PubMed  CAS  Google Scholar 

  15. BenEzra D, Cohen E, Behar-Cohen F. Uveitis and juvenile idiopathic arthritis: a cohort study. Clin Ophthalmol. 2007;1:513–8.

    PubMed  Google Scholar 

  16. Cassidy J, Kivlin J, Lindsley C, Nocton J. Ophthalmologic examinations in children with juvenile rheumatoid arthritis. Pediatrics. 2006;117:1843–5.

    Article  PubMed  Google Scholar 

  17. Raymaekers A, Foets B, Wouters C, Casteels I.Visual outcome in children with juvenile idiopathic arthritis related uveitis. Bull Soc Belge Ophtalmol. 2006:67-72.

  18. Thorne JE, Woreta F, Kedhar SR, et al. Juvenile idiopathic arthritis-associated uveitis: incidence of ocular complications and visual acuity loss. Am J Ophthalmol. 2007;143:840–6.

    Article  PubMed  Google Scholar 

  19. Kanski JJ. Anterior uveitis in juvenile rheumatoid arthritis. Arch Ophthalmol. 1977;95:1794–7.

    Article  PubMed  CAS  Google Scholar 

  20. Ohno S, Char DH, Kimura SJ, O’Connor GR. HLA antigens and antinuclear antibody titres in juvenile chronic iridocyclitis. Br J Ophthalmol. 1977;61:59–61.

    Article  PubMed  CAS  Google Scholar 

  21. Zulian F, Martini G, Falcini F, et al. Early predictors of severe course of uveitis in oligoarticular juvenile idiopathic arthritis. J Rheumatol. 2002;29:2446–53.

    PubMed  Google Scholar 

  22. Holland GN, Denove CS, Yu F. Chronic anterior uveitis in children: clinical characteristics and complications. Am J Ophthalmol. 2009;147:667-78 e5.

    Google Scholar 

  23. Chia A, Lee V, Graham EM, Edelsten C. Factors related to severe uveitis at diagnosis in children with juvenile idiopathic arthritis in a screening program. Am J Ophthalmol. 2003;135:757–62.

    Article  PubMed  Google Scholar 

  24. Woreta F, Thorne JE, Jabs DA, et al. Risk factors for ocular complications and poor visual acuity at presentation among patients with uveitis associated with juvenile idiopathic arthritis. Am J Ophthalmol. 2007;143:647–55.

    Article  PubMed  Google Scholar 

  25. Ohno S, Kimura SJ, O’Connor GR, Char DH. HLA antigens and uveitis. Br J Ophthalmol. 1977;61:62–4.

    Article  PubMed  CAS  Google Scholar 

  26. American Academy of Pediatrics Section on Rheumatology and Section on Ophthalmology. Guidelines for ophthalmologic examinations in children with juvenile rheumatoid arthritis. Pediatrics. 1993;92:295–6.

    Google Scholar 

  27. Jabs DA, Nussenblatt RB, Rosenbaum JT. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol. 2005;140:509–16.

    Article  PubMed  Google Scholar 

  28. Kump LI, Cervantes-Castaneda RA, Androudi SN, Foster CS. Analysis of pediatric uveitis cases at a tertiary referral center. Ophthalmology. 2005;112:1287–92.

    Article  PubMed  Google Scholar 

  29. Paroli MP, Speranza S, Marino M, et al. Prognosis of juvenile rheumatoid arthritis-associated uveitis. Eur J Ophthalmol. 2003;13:616–21.

    PubMed  CAS  Google Scholar 

  30. Ozdal PC, Vianna RN, Deschenes J. Visual outcome of juvenile rheumatoid arthritis-associated uveitis in adults. Ocul Immunol Inflamm. 2005;13:33–8.

    Article  PubMed  Google Scholar 

  31. de Boer J, Wulffraat N, Rothova A. Visual loss in uveitis of childhood. Br J Ophthalmol. 2003;87:879–84.

    Article  PubMed  Google Scholar 

  32. • Camuglia JE, Whitford CL, Hall AJ.Juvenile idiopathic arthritis associated uveitis in adults: a case series. Ocular immunology and inflammation. 2009;17:330-4. This article discusses the long-term outcome of adults diagnosed with JIA-U.

  33. Kanski JJ. Uveitis in juvenile chronic arthritis. Clin Exp Rheumatol. 1990;8:499–503.

    PubMed  CAS  Google Scholar 

  34. Edelsten C, Lee V, Bentley CR, et al. An evaluation of baseline risk factors predicting severity in juvenile idiopathic arthritis associated uveitis and other chronic anterior uveitis in early childhood. Br J Ophthalmol. 2002;86:51–6.

    Article  PubMed  Google Scholar 

  35. •• Thorne JE, Woreta FA, Dunn JP, Jabs DA.Risk of cataract development among children with juvenile idiopathic arthritis-related uveitis treated with topical corticosteroids. Ophthalmology. 2010;117:1436-41. This article discusses risk factors for cataract development in a JIA-U population and effects of the use of topical CS.

  36. Dana MR, Merayo-Lloves J, Schaumberg DA, Foster CS. Visual outcomes prognosticators in juvenile rheumatoid arthritis-associated uveitis. Ophthalmology. 1997;104:236–44.

    PubMed  CAS  Google Scholar 

  37. Kump LI, Castaneda RA, Androudi SN, et al. Visual outcomes in children with juvenile idiopathic arthritis-associated uveitis. Ophthalmology. 2006;113:1874–7.

    Article  PubMed  Google Scholar 

  38. • Van Gelder RN, Leveque TK.Cataract surgery in the setting of uveitis. Curr Opin Ophthalmol. 2009;20:42-5. This article discusses perioperative management of cataract surgery in adults and pediatric uveitis patients, including perioperative CS use, IOL choice, and other uveitis-specific surgical considerations.

  39. Wolf MD, Lichter PR, Ragsdale CG. Prognostic factors in the uveitis of juvenile rheumatoid arthritis. Ophthalmology. 1987;94:1242–8.

    PubMed  CAS  Google Scholar 

  40. Sijssens KM, Rothova A, Van De Vijver DA, et al. Risk factors for the development of cataract requiring surgery in uveitis associated with juvenile idiopathic arthritis. Am J Ophthalmol. 2007;144:574–9.

    Article  PubMed  Google Scholar 

  41. Giannini EH, Malagon CN, Van Kerckhove C, et al. Longitudinal analysis of HLA associated risks for iridocyclitis in juvenile rheumatoid arthritis. J Rheumatol. 1991;18:1394–7.

    PubMed  CAS  Google Scholar 

  42. Glass D, Litvin D, Wallace K, et al. Early-onset pauciarticular juvenile rheumatoid arthritis associated with human leukocyte antigen-DRw5, iritis, and antinuclear antibody. J Clin Invest. 1980;66:426–9.

    Article  PubMed  CAS  Google Scholar 

  43. Melin-Aldana H, Giannini EH, Taylor J, et al. Human leukocyte antigen-DRB1*1104 in the chronic iridocyclitis of pauciarticular juvenile rheumatoid arthritis. J Pediatr. 1992;121:56–60.

    Article  PubMed  CAS  Google Scholar 

  44. Miller ML, Fraser PA, Jackson JM, et al. Inherited predisposition to iridocyclitis with juvenile rheumatoid arthritis: selectivity among HLA-DR5 haplotypes. Proc Natl Acad Sci USA. 1984;81:3539–42.

    Article  PubMed  CAS  Google Scholar 

  45. Malagon C, Van Kerckhove C, Giannini EH, et al. The iridocyclitis of early onset pauciarticular juvenile rheumatoid arthritis: outcome in immunogenetically characterized patients. J Rheumatol. 1992;19:160–3.

    PubMed  CAS  Google Scholar 

  46. Zeggini E, Packham J, Donn R, et al. Association of HLA-DRB1*13 with susceptibility to uveitis in juvenile idiopathic arthritis in two independent data sets. Rheumatology (Oxford). 2006;45:972–4.

    Article  CAS  Google Scholar 

  47. Haas JP, Truckenbrodt H, Paul C, et al.: Subtypes of HLA-DRB1*03, *08, *11, *12, *13 and *14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis. Clinical and experimental rheumatology. 1994;12 Suppl 10:S7-14.

    Google Scholar 

  48. • Quinones K, Cervantes-Castaneda RA, Hynes AY, et al.: Outcomes of cataract surgery in children with chronic uveitis. J Cataract Refract Surg. 2009;35:725-31. This article discusses the successful outcome of cataract surgery in uveitis.

  49. BenEzra D, Cohen E. Cataract surgery in children with chronic uveitis. Ophthalmology. 2000;107:1255–60.

    Article  PubMed  CAS  Google Scholar 

  50. • Grajewski RS, Zurek-Imhoff B, Roesel M, et al.: Favourable outcome after cataract surgery with IOL implantation in uveitis associated with juvenile idiopathic arthritis. Acta Ophthalmol. 2011. This article discusses the use of IOL implantation in JIA-U, which has been controversial.

  51. Acevedo S, Quinones K, Rao V, et al. Cataract surgery in children with juvenile idiopathic arthritis associated uveitis. Int Ophthalmol Clin. 2008;48:1–7.

    Article  PubMed  Google Scholar 

  52. Saurenmann RK, Levin AV, Rose JB, et al. Tumour necrosis factor alpha inhibitors in the treatment of childhood uveitis. Rheumatology (Oxford). 2006;45:982–9.

    Article  CAS  Google Scholar 

  53. Simonini G, Taddio A, Cattalini M, et al. Prevention of flare recurrences in childhood-refractory chronic uveitis: an open-label comparative study of adalimumab versus infliximab. Arthritis Care Res (Hoboken). 2011;63:612–8.

    Article  CAS  Google Scholar 

  54. Vazquez-Cobian LB, Flynn T, Lehman TJ. Adalimumab therapy for childhood uveitis. J Pediatr. 2006;149:572–5.

    Article  PubMed  CAS  Google Scholar 

  55. Ardoin SP, Kredich D, Rabinovich E, et al. Infliximab to treat chronic noninfectious uveitis in children: retrospective case series with long-term follow-up. Am J Ophthalmol. 2007;144:844–9.

    Article  PubMed  CAS  Google Scholar 

  56. Biester S, Deuter C, Michels H, et al. Adalimumab in the therapy of uveitis in childhood. Br J Ophthalmol. 2007;91:319–24.

    Article  PubMed  Google Scholar 

  57. Sen HN, Levy-Clarke G, Faia LJ, et al.: High-dose daclizumab for the treatment of juvenile idiopathic arthritis-associated active anterior uveitis. American journal of ophthalmology. 2009;148:696-703 e1.

    Google Scholar 

  58. Angeles-Han S, Flynn T, Lehman T. Abatacept for refractory juvenile idiopathic arthritis-associated uveitis- a case report. J Rheumatol. 2008;35:1897–8.

    PubMed  Google Scholar 

  59. Zulian F, Balzarin M, Falcini F. Abatacept for severe anti-tumor necrosis factor alpha refractory juvenile idiopathic arthritis-related uveitis. Arthritis Care Res (Hoboken). 2010;62:821–5.

    Article  CAS  Google Scholar 

  60. Kenawy N, Cleary G, Mewar D, et al.: Abatacept: a potential therapy in refractory cases of juvenile idiopathic arthritis-associated uveitis. Graefe’s archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2011;249:297-300.

  61. Albini TA, Bajenaru ML, Ruggeri M, et al. Optical coherence tomography in experimental autoimmune uveitis. ARVO Meeting Abstracts. 2008;49:4772.

    Google Scholar 

  62. Jancevski M, Foster CS. Cataracts and uveitis. Discov Med. 2010;9:51–4.

    PubMed  Google Scholar 

  63. Rabinovich CE. Treatment of juvenile idiopathic arthritis-associated uveitis: challenges and update. Curr Opin Rheumatol. 2011;23:432–6.

    Article  PubMed  CAS  Google Scholar 

  64. Lam LA, Lowder CY, Baerveldt G, et al. Surgical management of cataracts in children with juvenile rheumatoid arthritis-associated uveitis. Am J Ophthalmol. 2003;135:772–8.

    Article  PubMed  Google Scholar 

  65. • Sijssens KM, Los LI, Rothova A, et al.:Long-term ocular complications in aphakic versus pseudophakic eyes of children with juvenile idiopathic arthritis-associated uveitis. The British journal of ophthalmology. 2010;94:1145-9. This report reviewed 48 eyes of 29 children with JIA-U who underwent cataract surgery prior to age 16 years. In this series, IOL use did not appear to increase the risk of secondary complications, including ocular hypertension and macular edema, and tended to achieve better VA than patients who did not receive an IOL.

  66. Alio JL, Chipont E, BenEzra D, Fakhry MA. Comparative performance of intraocular lenses in eyes with cataract and uveitis. J Cataract Refract Surg. 2002;28:2096–108.

    Article  PubMed  Google Scholar 

  67. Papaliodis GN, Nguyen QD, Samson CM, Foster CS. Intraocular lens tolerance in surgery for cataracta complicata: assessment of four implant materials. Semin Ophthalmol. 2002;17:120–3.

    Article  PubMed  Google Scholar 

  68. Alexandrakis G, Peterseim MM, Wilson ME. Clinical outcomes of pars plana capsulotomy with anterior vitrectomy in pediatric cataract surgery. J AAPOS. 2002;6:163–7.

    Article  PubMed  Google Scholar 

  69. Jensen AA, Basti S, Greenwald MJ, Mets MB. When may the posterior capsule be preserved in pediatric intraocular lens surgery? Ophthalmology. 2002;109:324–7. discussion 8.

    Article  PubMed  Google Scholar 

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Acknowledgments

This work was supported by a grant from the American College of Rheumatology Research and Education Foundation and the Arthritis Foundation Career Development Bridge Funding Award, by a K23EY021760 grant from the National Eye Institute (content is solely the responsibility of the authors and does not necessarily represent the official views of the National Eye Institute or the National Institutes of Health), and by an unrestricted grant from Research to Prevent Blindness to the Emory Eye Center (New York, NY).

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Correspondence to Sheila Angeles-Han.

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Angeles-Han, S., Yeh, S. Prevention and Management of Cataracts in Children with Juvenile Idiopathic Arthritis–Associated Uveitis. Curr Rheumatol Rep 14, 142–149 (2012). https://doi.org/10.1007/s11926-011-0229-z

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