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Dendritic Cells: Novel Players in Fibrosis and Scleroderma

  • SCLERODERMA (J VARGA, SECTION EDITOR)
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Abstract

Dendritic cells are professional antigen-presenting cells that are most studied for their function in mediating T-cell tolerance and T-cell activation. In addition, recent evidence indicates that dendritic cells can regulate the vasculature and function of fibroblast-type cells. The potential contribution of dendritic cells to scleroderma and fibrosis is not well-understood. In this article, we review recent studies as well as describe our own ongoing work that points toward a role for dendritic cells in scleroderma and fibrosis.

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Acknowledgments

The author gratefully acknowledges Sha Tian for her expert technical assistance and Dr. Fairouz Benahmed for critical reading of the manuscript.

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No potential conflicts of interest relevant to this article were reported.

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  1. Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA

    Theresa T. Lu

  2. Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, 10021, USA

    Theresa T. Lu

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Lu, T.T. Dendritic Cells: Novel Players in Fibrosis and Scleroderma. Curr Rheumatol Rep 14, 30–38 (2012). https://doi.org/10.1007/s11926-011-0215-5

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