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Behçet’s Syndrome

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Abstract

Behçet’s syndrome is a systemic vasculitis with an unknown etiology affecting the small and large vessels of the venous and arterial systems. At least two clusters of disease expression have been described. The first includes superficial vein thrombosis, deep vein thrombosis, and dural sinus thrombi. The second includes acne, arthritis, and enthesitis. The presence of these clusters suggests there may be more than one disease mechanism operative in this complex disorder. Recent European League Against Rheumatism guidelines are useful for the management of the disease in organ systems distinct from the vascular, neurological, and gastrointestinal systems. This is because of a lack of controlled studies evaluating such vascular, neurological, and gastrointestinal complications.

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Disclosure

Dr. Yusuf Yazici has served as a consultant for Bristol-Myers Squibb, Celgene Corp., Centocor Ortho Biotech, Genentech, Roche, and UCB.

Dr. Yurdakul has received travel support from Bristol-Myers Squibb.

Dr. Hasan Yazici has received travel support and served as a speaker/consultant for Schering-Plough, Wyeth, Bristol-Myers Squibb, and Celgene Corp.

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Authors and Affiliations

  1. New York University School of Medicine, New York University Hospital for Joint Diseases, 246 East 20th Street, New York, NY, 10003, USA

    Yusuf Yazici

  2. Department of Medicine, Division of Rheumatology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey

    Sebahattin Yurdakul & Hasan Yazici

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  1. Yusuf Yazici
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  2. Sebahattin Yurdakul
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  3. Hasan Yazici
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Correspondence to Yusuf Yazici.

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Yazici, Y., Yurdakul, S. & Yazici, H. Behçet’s Syndrome. Curr Rheumatol Rep 12, 429–435 (2010). https://doi.org/10.1007/s11926-010-0132-z

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  • DOI: https://doi.org/10.1007/s11926-010-0132-z

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