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Nephrogenic systemic fibrosis: An update

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Abstract

Nephrogenic systemic.brosis (NSF), previously known as nephrogenic fibrosing dermopathy, is an emerging systemic fibrosing disorder that develops in the setting of renal insufficiency. Since its recognition in 1997, several case reports of NSF have been published in the rheumatology literature, reflecting the increasing incidence and recognition of this disorder in the United States and abroad. As rheumatology professionals are commonly the first to encounter newly developing cases, it is imperative that they recognize the symptoms and comorbidities of NSF and initiate work-up and treatment. To date, the precise causes of NSF have not been established; however, several promising lines of inquiry have led to a new model of the disorder. This model speculates that circulating fibrocytes of bone marrow origin are aberrantly recruited to the skin and other systemic sites by a process likely triggered or exacerbated by endothelial damage.

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References and Recommended Reading

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Authors and Affiliations

  1. Departments of Dermatology and Pathology, Yale University, 15 York Street, LMP 5031, PO Box 208059, 06520-8059, New Haven, CT, USA

    Shawn E. Cowper MD

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  1. Shawn E. Cowper MD
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  2. Philip J. Boyer MD, PhD
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Correspondence to Shawn E. Cowper MD.

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Cowper, S.E., Boyer, P.J. Nephrogenic systemic fibrosis: An update. Curr Rheumatol Rep 8, 151–157 (2006). https://doi.org/10.1007/s11926-006-0056-9

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  • DOI: https://doi.org/10.1007/s11926-006-0056-9

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