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Chemokines: Their role in rheumatoid arthritis

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Abstract

Chemokines are small proteins that can act on cells that express matching receptors. They are best known for their role in migration of cells, especially immune cells. Chemo-kine/ chemokine-receptor pairs are often functionally cate-gorized into three groups: inflammatory, homeostatic, and angiogenic/angiostatic, although functions sometimes over-lap. Interfering with the interaction between chemokines and their receptors is currently under investigation as a therapeutic strategy in rheumatoid arthritis.

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Authors and Affiliations

  1. Division of Clinical Immunology and Rheumatology, F4-218, Academic Medical Center/University of Amsterdam, Meibergdreef 9, NL-1105 AZ, Amsterdam, The Netherlands

    Clarissa E. Vergunst MD

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  1. Clarissa E. Vergunst MD
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  2. Paul P. Tak MD, PhD
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Vergunst, C.E., Tak, P.P. Chemokines: Their role in rheumatoid arthritis. Curr Rheumatol Rep 7, 382–388 (2005). https://doi.org/10.1007/s11926-005-0026-7

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