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Impaired clearance of apoptotic cells in systemic lupus erythematosus: Challenge of T and B cell tolerance

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References

  1. Winkler TH, Jahn S, Kalden JR: IgG human monoclonal anti- DNA autoantibodies from patients with systemic lupus erythematosus. Clin Exp Immunol 1991, 85:379–385.

    Article  PubMed  CAS  Google Scholar 

  2. Winkler TH, Fehr H, Kalden JR: Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas. Eur J Immunol 1992, 22:1719–1728.

    Article  PubMed  CAS  Google Scholar 

  3. Rekvig O: Polyoma induced autoimmunity to DNA: experimental systems and clinical observations in human SLE. Lupus 1997, 6:325–326.

    PubMed  CAS  Google Scholar 

  4. Moens U, Seternes OM, Hey AW, et al.: In vivo expression of a single viral DNA-binding protein generates systemic lupus erythematosus-related autoimmunity to double-stranded DNA and histones. Proc Natl Acad Sci U S A 1995, 92:12393–12397.

    Article  PubMed  CAS  Google Scholar 

  5. Desai-Mehta A, Mao C, Rajagopalan S, et al.: Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus. J Clin Invest 1995, 95:531–541.

    PubMed  CAS  Google Scholar 

  6. Voll RE, Roth EA, Girkontaite I, et al.: Histone-specific Th0 and Th1 clones derived from systemic lupus erythematosus patients induce double-stranded DNA antibody production. Arthritis Rheum 1997, 40:2162–2171.

    Article  PubMed  CAS  Google Scholar 

  7. Casciola-Rosen LA, Anhalt G, Rosen A: Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes [see comments]. J Exp Med 1994, 179:1317–1330.

    Article  PubMed  CAS  Google Scholar 

  8. Rosen A, Casciola-Rosen L, Ahearn J: Novel packages of viral and self-antigens are generated during apoptosis. J Exp Med 1995, 181:1557–1561.

    Article  PubMed  CAS  Google Scholar 

  9. Utz PJ, Hottelet M, Schur PH, Anderson P: Proteins phosphorylated during stress-induced apoptosis are common targets for autoantibody production in patients with systemic lupus erythematosus. J Exp Med 1997, 185:843–854.

    Article  PubMed  CAS  Google Scholar 

  10. Casiano CA, Ochs RL, Tan EM: Distinct cleavage products of nuclear proteins in apoptosis and necrosis revealed by autoantibody probes. Cell Death Differ 1998, 5:183–190.

    Article  PubMed  CAS  Google Scholar 

  11. Casciola-Rosen L, Andrade F, Ulanet D, et al.: Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity. J Exp Med 1999, 190:815–826.

    Article  PubMed  CAS  Google Scholar 

  12. Rutjes SA, Utz PJ, van der Heijden A, et al.: The La (SS-B) autoantigen, a key protein in RNA biogenesis, is dephosphorylated and cleaved early during apoptosis. Cell Death Differ 1999, 6:976–986.

    Article  PubMed  CAS  Google Scholar 

  13. Savill J: Apoptosis in resolution of inflammation. J Leukoc Biol 1997, 61:375–380.

    PubMed  CAS  Google Scholar 

  14. Voll RE, Herrmann M, Roth EA, et al.: Immunosuppressive effects of apoptotic cells [letter]. Nature 1997, 390:350–351.

    Article  PubMed  CAS  Google Scholar 

  15. Fadok VA, Bratton DL, Konowal A, et al.: Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest 1998, 101:890–898.

    PubMed  CAS  Google Scholar 

  16. Ponner BB, Stach C, Zoller O, et al.: Induction of apoptosis reduces immunogenicity of human T-cell lines in mice. Scand J Immunol 1998, 47:343–347.

    Article  PubMed  CAS  Google Scholar 

  17. Herrmann M, Zoller OM, Hagenhofer M, et al.: What triggers anti-dsDNA antibodies? Mol Biol Rep 1996, 23:265–267.

    Article  PubMed  CAS  Google Scholar 

  18. Herrmann M, Voll RE, Zoller OM, et al.: Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998, 41:1241–1250.

    Article  PubMed  CAS  Google Scholar 

  19. Herrmann M, Voll RE, Kalden JR: Etiopathogenesis of systemic lupus erythematosus. Immunol Today 2000, 21:424–426.

    Article  PubMed  CAS  Google Scholar 

  20. Rosen A, Casciola-Rosen L: Macromolecular substrates for the ICE-like proteases during apoptosis. J Cell Biochem 1997, 64:50–54.

    Article  PubMed  CAS  Google Scholar 

  21. Melino G, Piacentini M: ‘Tissue’ transglutaminase in cell death: a downstream or a multifunctional upstream effector? FEBS Lett 1998, 430:59–63.

    Article  PubMed  CAS  Google Scholar 

  22. Deng H, Apple R, Clare-Salzler M, et al.: Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease. J Exp Med 1993, 178:1675–1680.

    Article  PubMed  CAS  Google Scholar 

  23. Shokat KM, Goodnow CC: Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature 1995, 375:334–338.

    Article  PubMed  CAS  Google Scholar 

  24. Carroll MC: The role of complement and complement receptors in induction and regulation of immunity. Annu Rev Immunol 1998, 16:545–568.

    Article  PubMed  CAS  Google Scholar 

  25. Camacho SA, Kosco-Vilbois MH, Berek C: The dynamic structure of the germinal center. Immunol Today 1998, 19:511–514.

    Article  PubMed  CAS  Google Scholar 

  26. Korb LC, Ahearn JM: C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited. J Immunol 1997, 158:4525–4528.

    PubMed  CAS  Google Scholar 

  27. Mevorach D, Gershov D, Elkon KB: Complement-dependent clearance of apoptotic cells by human macrophages. J Exp Med 1998, 188:2313–2320.

    Article  PubMed  CAS  Google Scholar 

  28. Carroll MC: The role of complement in B cell activation and tolerance. Adv Immunol 2000, 74:61–88.

    Article  PubMed  CAS  Google Scholar 

  29. Svensson B: Monocyte in vitro function in systemic lupus erythematosus (SLE), I: a clinical and immunological study. Scand J Rheumatol Suppl 1980, 31:29–41.

    PubMed  CAS  Google Scholar 

  30. Svensson B: Occurrence of deficient monocyte yeast cell phagocytosis in presence of rheumatic sera. Scand J Rheumatol Suppl 1980, 31:21–27.

    PubMed  CAS  Google Scholar 

  31. Hurst NP, Nuki G, Wallington T: Evidence for intrinsic cellular defects of ‘complement’ receptor-mediated phagocytosis in patients with systemic lupus erythematosus (SLE). Clin Exp Immunol 1984, 55:303–312.

    PubMed  CAS  Google Scholar 

  32. Salmon JE, Kimberly RP, Gibofsky A, Fotino M: Defective mononuclear phagocyte function in systemic lupus erythematosus: dissociation of Fc receptor-ligand binding and internalization. J Immunol 1984, 133:2525–2531.

    PubMed  CAS  Google Scholar 

  33. Gaipl US, Kuenkele S, Voll RE, et al.: Complement binding is an early feature of necrotic and a rather late event during apoptotic cell death. Cell Death Differ 2001, 8:327–334.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute for Clinical Immunology and Rheumatology, Department of Internal Medicine III, Friedrich-Alexander University Erlangen-Nuremberg, Krankenhausstrasse 12, 91054, Erlangen, Germany

    Martin Herrmann MD, PhD

Authors
  1. Susanne Kuenkele MD
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  2. Thomas D. Beyer MD
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  3. Reinhard E. Voll MD
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  4. Joachim R. Kalden MD
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  5. Martin Herrmann MD, PhD
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Kuenkele, S., Beyer, T.D., Voll, R.E. et al. Impaired clearance of apoptotic cells in systemic lupus erythematosus: Challenge of T and B cell tolerance. Curr Rheumatol Rep 5, 175–177 (2003). https://doi.org/10.1007/s11926-003-0061-1

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  • DOI: https://doi.org/10.1007/s11926-003-0061-1

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