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Defining and identifying early onset bipolar spectrum disorder

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Abstract

Early onset bipolar spectrum disorder (EOBPSD) is difficult to diagnose because of symptom overlap with other disorders and nearly ubiquitous comorbidity. A thorough assessment of EOBPSD should include the following: 1) a timeline of the child’s development, from birth to present, showing the episodic nature of EOBPSD; 2) a structured clinical interview determining comorbidity and differential diagnosis; 3) a family history genogram to ascertain familial loading and environmental stressors, which informs case conceptualization; 4) depression and mania rating scales to assess symptom severity and track treatment outcome; 5) global rating scales to obtain cross-informant data and inform broad-based treatments; and 6) a current mood log to document baseline functioning and track treatment outcome. Examples of a timeline, family history genogram, and current mood log are presented. This comprehensive approach to assessing EOBPSD, a severe and possibly lifelong disorder, is strongly advocated. No scale, instrument, or technique alone is adequate to diagnose EOBPSD.

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References and Recommended Reading

  1. Lofthouse N, Fristad MA: Psychosocial interventions for children with early-onset bipolar spectrum disorder. Clin Child Fam Psychol Rev 2003, in press.

  2. Leibenluft E, Charney DS, Towbin KE, et al.: Defining clinical phenotypes of juvenile mania. Am J Psychiatry 2003, 160:430–437. This article was written by the National Institute of Mental Health team devoted to research on EOBPSD. The article highlights current diagnostic problems and controversies and offers suggestions for remediation.

    Article  PubMed  Google Scholar 

  3. Carlson GA, Jensen PS, Findling RL, et al.: Methodological issues and controversies in clinical trials with child and adolescent patients with bipolar disorder: report of a consensus conference. J Child Adolesc Psychopharmacol 2003, 13:13–27. This article presents the findings from leaders in the field of BP research on topics such as inclusion criteria, assessment and outcome measures, ethical issues, and directions for future research.

    Article  PubMed  Google Scholar 

  4. Weckerly J: Pediatric bipolar mood disorder. J Dev Behav Pediatr 2002, 23:42–56.

    PubMed  Google Scholar 

  5. Cassidy F, Peiper CF, Carroll BJ: Subtypes of mania determined by grade of membership analysis. Neuropsychopharmacology 2000, 25:373–383.

    Article  Google Scholar 

  6. Dilsaver SC, Chen YR, Shoaib AM, Swann AC: Phenomenology of mania: evidence for distinct depressed, dysphoric, and euphoric presentations. Am J Psychiatry 1999, 156:426–430.

    PubMed  CAS  Google Scholar 

  7. Findling RL, Gracious BL, McNamara NK, et al.: Rapid, continuous cycling and psychiatric co-morbidity in pediatric bipolar I disorder. Bipolar Disord 2001, 3:202–210.

    PubMed  CAS  Google Scholar 

  8. Geller B, Craney JL, Bolhofner K, et al.: Two-year prospective follow-up of children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry 2002, 159:927–933.

    Article  PubMed  Google Scholar 

  9. Biederman J: Resolved: mania is mistaken for ADHD in prepubertal children. J Am Acad Child Adolesc Psychiatry 1998, 37:1096–1098.

    Google Scholar 

  10. Mick E, Biederman J, Pandina G, Faraone SV: A preliminary meta-analysis of the Child Behavior Checklist in pediatric bipolar disorder. Biol Psychiatry 2003, 53:1021–1027.

    Article  PubMed  Google Scholar 

  11. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, edn 4 (Text Revision). Washington, DC: American Psychiatric Association; 2000.

    Book  Google Scholar 

  12. Weller EB, Calvert SM, Weller RA: Bipolar disorder in children and adolescents: diagnosis and treatment. Curr Opin Psychiatry 2003, 16:383–388.

    Article  Google Scholar 

  13. Craney JL, Geller B: A prepubertal and early adolescent bipolar disorder-I phenotype: review of phenomenology and longitudinal course. Bipolar Disord 2003, 5:243–256.

    Article  PubMed  Google Scholar 

  14. Geller B, Zimerman B, Williams M, et al.: DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls. J Child Adolesc Psychopharmacol 2002, 12:11–25.

    Article  PubMed  Google Scholar 

  15. Pollock RA, Kuo IK: A view of bipolar disorder across the lifespan: selected sessions from the fifth International Conference on bipolar disorder. Medscape from WebMD. Available at http://www.medscape.com/viewarticle/458703. Accessed August 26, 2003.

  16. Geller B, Cook EHJ: Ultradian rapid cycling in prepubertal and early adolescent bipolarity is not in transmission disequilibrium with val/met COMT alleles. Biol Psychiatry 2000, 47:605–609.

    Article  PubMed  CAS  Google Scholar 

  17. Geller B, Zimerman B, Williams M, et al.: Phenomenology of prepubertal and early adolescent bipolar disorder: examples of elated mood, grandiose behaviors, decreased need for sleep, racing thoughts and hypersexuality. J Child Adolesc Psychopharmacol 2002, 12:3–9.

    Article  PubMed  Google Scholar 

  18. Harrington R, Myatt T: Is preadolescent mania the same condition as adult mania? A British perspective. Biol Psychiatry 2003, 53:961–969.

    Article  PubMed  Google Scholar 

  19. Silva RR, Matzner F, Diaz J, et al.: Bipolar disorder in children and adolescents: a guide to diagnosis and treatment. CNS Drugs 1999, 12:437–450.

    Article  Google Scholar 

  20. Kessler RC, McGonagle KA, Zhao S, et al.: Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States from the National Comorbidity Survey. Arch Gen Psychiatry 1994, 51:8–19.

    PubMed  CAS  Google Scholar 

  21. Wozniak J, Beiderman J, Mundy E, et al.: Mania-like symptoms suggestive of childhood onset bipolar disorder in clinically referred children. J Am Acad Child Adolesc Psychiatry 1995, 34:867–876.

    Article  PubMed  CAS  Google Scholar 

  22. Geller B, Sun K, Zimerman B, et al.: Complex and rapid cycling in bipolar children and adolescents: a preliminary study. J Affect Disord 1995, 34:259–268.

    Article  PubMed  CAS  Google Scholar 

  23. Geller B, Craney JL, Bolhofner K, et al.: One year recovery and relapse rates for children with a prepubertal and early onset bipolar disorder phenotype. Am J Psychiatry 2001, 158:303–305.

    Article  PubMed  CAS  Google Scholar 

  24. Pollock RA, Kuo IK: Children and adolescents with bipolar disorder: expert review. Selected sessions from the 5th International Conference on Bipolar Disorder. Medscape from WebMD. Available at http://www.medscape.com/viewarticle/ 458702. Accessed August 26, 2003.

  25. Cerel J, Fristad MA: Scaling structured interview data: a comparison of two methods. J Am Acad Child Adolesc Psychiatry 2001, 40:341–346.

    Article  PubMed  CAS  Google Scholar 

  26. Weller EB, Weller RA, Rooney MT, Fristad MA: Children’s Interview for Psychiatric Syndromes. Washington, DC: American Psychiatric Press, Inc.; 1999.

    Google Scholar 

  27. Carlson GA, Youngstrom EA: Clinical implications of pervasive manic symptoms in children. Biol Psychiatry 2003, 53:1050–1058.

    Article  PubMed  Google Scholar 

  28. Van Dusen Randazzo K, Landsverk J, Ganger W: Three informants’ reports of child behaviors: parents, teachers, and foster parents. J Am Acad Child Adolesc Psychiatry 2003, 42:1343–1359.

    Article  Google Scholar 

  29. Angold A, Costello EJ, Rutter M: Precision, reliability, and accuracy in the dating of symptom onsets in child and adolescent psychopathology. J Child Psychol Psychiatry 1996, 37:657–664.

    Article  PubMed  CAS  Google Scholar 

  30. McClure EB, Kubiszyn T, Kaslow NJ: Advances in the diagnosis and treatment of childhood mood disorders. Prof Psychol Res Pr 2002, 33:125–134.

    Article  Google Scholar 

  31. Andreasen NC, Endicott J, Spitzer RL, Winokur G: The family history method using diagnostic criteria: reliability and validity. Arch Gen Psychiatry 1977, 34:1229–1235.

    PubMed  CAS  Google Scholar 

  32. Fristad MA: [Unpublished manuscript]. Columbus: Ohio State University; 1996.

    Google Scholar 

  33. Kendler KS, Roy MA: Validity of a diagnosis of lifetime major depression obtained by personal interview versus family history. Am J Psychiatry 1995, 152:1608–1614.

    PubMed  CAS  Google Scholar 

  34. Kendall PC, Cantwell DP, Kazdin AE: Depression in children and adolescents: assessment issues and recommendations. Cogn Ther Res 1989, 13:109–146.

    Article  Google Scholar 

  35. Young RC, Biggs JT, Ziegler VE, Meyer DA: A rating scale for mania: reliability, validity, and sensitivity. Br J Psychiatry 1978, 133:429–435.

    Article  PubMed  CAS  Google Scholar 

  36. Gracious BL, Youngstrom EA, Findling RL, Calabrese JR: Discriminative validity of a parent version of the Young Mania Rating Scale. J Am Acad Child Adolesc Psychiatry 2002, 41:1350–1359.

    Article  PubMed  Google Scholar 

  37. Fristad MA, Weller EB, Weller RA: The Mania Rating Scale: can it be used in children? A preliminary report. J Am Acad Child Adolesc Psychiatry 1992, 31:252–257.

    Article  PubMed  CAS  Google Scholar 

  38. Fristad MA, Weller EB, Weller RA: The Mania Rating Scale (MRS): further reliability and validity studies with children. Ann Clin Psychiatry 1995, 7:127–132.

    PubMed  CAS  Google Scholar 

  39. Endicott V, Spitzer RL: A diagnostic interview: the Schedule for Affective Disorders and Schizophrenia. Arch Gen Psychiatry 1978, 35:837–848.

    PubMed  CAS  Google Scholar 

  40. Hughes CW, Rintelmann J, Emslie GJ, et al.: A revised anchored version of the BPRS-C for childhood psychiatric disorders. J Child Adolesc Psychopharmacol 2001, 11:77–93.

    Article  PubMed  CAS  Google Scholar 

  41. Depue RA, Krauss S, Spoont MR, Arbisi P: General Behavior Inventory identification of unipolar and bipolar affective conditions in a nonclinical university population. J Abnorm Psychol 1989, 98:117–126.

    Article  PubMed  CAS  Google Scholar 

  42. Youngstrom EA, Findling RL, Danielson CK, Calabrese JR: Discriminative validity of parent report of hypomanic and depressive symptoms on the General Behavior Inventory. Psychol Assess 2001, 13:267–276.

    Article  PubMed  CAS  Google Scholar 

  43. Ryan ND: The pharmacological treatment of child and adolescent bipolar disorder. In Bipolar Disorder in Childhood and Early Adolescence. Edited by Geller B, DelBello MP. New York: Guilford Press; 2003:255–271.

    Google Scholar 

  44. Poznanski EO: Preliminary studies of the reliability and validity of the Children’s Depression Rating Scale. J Am Acad Child Psychiatry 1984, 23:191–197.

    Article  PubMed  CAS  Google Scholar 

  45. Achenbach TM: Manual for the Child Behavior Checklist/4-18 and 1991 Profile. Burlington: University of Vermont Department of Psychiatry; 1991.

    Google Scholar 

  46. Achenbach TM: Manual for the Teacher Report Form and 1991 Profile. Burlington: University of Vermont Department of Psychiatry; 1991.

    Google Scholar 

  47. Elliott SN, Gresham FM, Freeman T, McCloskey G: Teacher and observer ratings of children’s social skills: validation of the Social Skills Rating Scales. J Psychoeducational Assess 1988, 6:152–161.

    Article  Google Scholar 

  48. Merrell KW: Using behavioral rating scales to assess social skills and antisocial behavior in school settings: development of the School Social Behavior Scales. School Psych Rev 1993, 22:115–133.

    Google Scholar 

  49. Mattison RE, Gadow KD, Sprafkin J, et al.: A DSM-IV-Referenced teacher rating scale for use in clinical management. J Am Acad Child Adolesc Psychiatry 2003, 42:442–449.

    PubMed  Google Scholar 

  50. Nottelmann E, Biederman J, Birmaher B, et al.: National Institute of Mental Health research roundtable on prepubertal bipolar disorder. J Am Acad Child Adolesc Psychiatry 2001, 40:871–878.

    Article  Google Scholar 

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Quinn, C.A., Fristad, M.A. Defining and identifying early onset bipolar spectrum disorder. Curr Psychiatry Rep 6, 101–107 (2004). https://doi.org/10.1007/s11920-004-0049-1

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