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A Comprehensive Review of Analgesia and Pain Modalities in Hip Fracture Pathogenesis

  • Hot Topics in Pain and Headache (N Rosen, Section Editor)
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Abstract

Purpose of Review

Hip fracture is common in the elderly population, painful and costly. The present investigation was undertaken to review epidemiology, socio-economic and medical implications, relevant anatomy, and anesthetic and pain modalities of hip fracture.

Recent Findings

A literature search of PubMed, Ovid Medline, and Cochrane databases was conducted in December 2018 to identify relevant published clinical trials, review articles, and meta-analyses studies related to anesthetic and pain modalities of hip fracture. The acute pain management in these situations is often challenging. Common issues associated with morbidity and mortality include patients’ physiological decrease in function, medical comorbidities, and cognitive impairment, which all can confound and complicate pain assessment and treatment.

Summary

Perioperative multidisciplinary and multimodal approaches require medical, surgical, and anesthesiology teams employing adequate preoperative optimization. Reduction in pain and disability utilizing opioid and non-opioid therapies, regional anesthesia, patient-tailored anesthetic approach, and delirium prevention strategies seems to ensure best outcomes.

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References

Papers of particular interest, published recently, have been highlighted as: •• Of major importance

  1. Lewiecki EM, Wright NC, Curtis JR, Siris E, Gagel RF, Saag KG, et al. Hip fracture trends in the United States, 2002 to 2015. Osteoporos Int. 2018;29:717–22.

  2. Zuckerman JD. Hip fracture. N Engl J Med. 1996;334(23):1519–25.

    CAS  PubMed  Google Scholar 

  3. Guay J, Parker MJ, Griffiths R, Kopp SL. Peripheral nerve blocks for hip fractures: a Cochrane review. Anesth Analg. 2017;126(5):1.

    Google Scholar 

  4. •• Klestil T, Röder C, Stotter C, Winkler B, Nehrer S, Lutz M, et al. Impact of timing of surgery in elderly hip fracture patients: a systematic review and meta-analysis. Sci Rep. 2018;8(1):13933 Systemic review and meta-analysis of impact of timing of surgery in geriatric hip fractures.

  5. Roberts KC, Brox WT, Jevsevar DS, Sevarino K. Management of hip fractures in the elderly. J Am Acad Orthop Surg. 2015;23(2):131–7.

    PubMed  Google Scholar 

  6. Karnuta JM, Navarro SM, Haeberle HS, Billow DG, Krebs VE, Ramkumar PN. Bundled care for hip fractures: a machine learning approach to an untenable patient-specific payment model. J Orthop Trauma. 2019:1.

  7. Sheehan SE, Shyu JY, Weaver MJ, Sodickson AD, Khurana B. Proximal femoral fractures: what the orthopedic surgeon wants to know. RadioGraphics. 2015;35(5):1563–84.

    PubMed  Google Scholar 

  8. Brunner LC, Eshilian-Oates L, Kuo TY. Hip fractures in adults. AFP. 2003;67(3):537–43.

    Google Scholar 

  9. Gold M, Varacallo M. Anatomy, bony pelvis and lower limb, hip joint. [updated 2018 Nov 14]. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2018 Jan.

  10. Faller A, Schuenke M. “Hip anatomy.” The human body: an introduction to structure and function, Thieme, 2007, pp. 174–175.

  11. Platzer, W. Color atlas of human anatomy vol. 1 locomotor system. Thieme, 2015. Pg. 198.

  12. Birnbaum K, Prescher A, Hepler S, Heller KD. The sensory innervation of the hip joint—an anatomical study. Surg Radiol Anat. 1998;19(6):371–5. https://doi.org/10.1007/s00276-997-0371-5.

    Article  Google Scholar 

  13. Kishner, Stephen. “Hip joint anatomy.” Sickle cell anemia differential diagnoses, 2017, emedicine.medscape.com/article/1898964-overview.

  14. Biga, L M, Dawson S, Harwell A, Hopkins R. et al. “Anatomy & physiology.” 4.3 Connective Tissue Supports and Protects | Anatomy & Physiology, Open Oregon State, Oregon State University, 2008.

  15. Gold M, Varacallo M. Anatomy, bony pelvis and lower limb, hip joint. [updated 2018 Nov 14]. In: StatPearls [internet]. Treasure Island (FL): StatPearls Publishing; 2018.

  16. Dee R. Structure and function of hip joint innervation. Ann R Coll Surg Engl. 1969;45(6):357–74.

    CAS  PubMed  PubMed Central  Google Scholar 

  17. •• Boddaert J, Raux M, Khiami F, Riou B. Perioperative management of elderly patients with hip fracture. Anesthesiology. 2014;121(6):1336–41 Excellent manuscript on perioperative management of geriatric hip fracture patients.

    PubMed  Google Scholar 

  18. Shiga T, Wajima Z, Ohe Y. Is operative delay associated with increased mortality of hip fracture patients? Systematic review, meta-analysis, and meta-regression. Can J Anaesth. 2008;55(3):146–54.

    PubMed  Google Scholar 

  19. Mears SC, Kates SL. A guide to improving the care of patients with fragility fractures, edition 2. Geriatr Orthop Surg Rehabil. 2015;6(2):58–120.

    PubMed  PubMed Central  Google Scholar 

  20. •• Schurrah A, Shiner CT, Stevens JA, Faux SG. Regional nerve blockade for early analgesic management of elderly patients with hip fracture—a narrative review. Anaesthesia. 2018;73(6):769–83. Review of challenges involving acute pain management in the elderly and role of regional nerve blocks in hip fracture.

  21. Fong HK, Sands LP, Leung JM. The role of postoperative analgesia in delirium and cognitive decline in elderly patients: a systematic review. Anesth Analg. 2006;102(4):1255–66.

    PubMed  Google Scholar 

  22. Yang Y, Zhao X, Dong T, Yang Z, Zhang Q, Zhang Y. Risk factors for postoperative delirium following hip fracture repair in elderly patients: a systematic seview and meta analysis. Aging Clin Exp Res. 2017;29(2):115–26.

    PubMed  Google Scholar 

  23. Clegg A, Young J. Which medications to avoid in people at risk of delirium: a systematic review. Age Ageing. 2011;40:23–9.

    PubMed  Google Scholar 

  24. Morrison RS, Magaziner J, Gilbert M, Koval KJ, McLaughlin MA, Orosz G, et al. Relationship between pain and opioid analgesics on the development of delirium following hip fracture. J Gerontol Med Sci. 2003;58A:76–81.

  25. Morrison RS, Magaziner J, McLaughlin MA, Orosz G, Silberzweig SB, Koval KJ, et al. The impact of post-operative pain on outcomes following hip fracture. Pain. 2003;103(3):303–11.

    PubMed  Google Scholar 

  26. Hung WW, Egol KA, Zuckerman JD, Siu AL. Hip fracture management: tailoring care for the older patient. J Am Med Assoc. 2012;307:2185–94.

    CAS  Google Scholar 

  27. Feldt KS, Ryden MB, Miles S. Treatment of pain in cognitively impaired compared with cognitively intact older patients with hip-fracture. J Am Geriatr Soc. 1998;46:1079–85.

    CAS  PubMed  Google Scholar 

  28. Morrison RS, Siu AL. A comparison of pain and its treatment in advanced dementia and cognitively intact patients with hip fracture. J Pain Symptom Manag. 2000;19:240–8.

    CAS  Google Scholar 

  29. Chau DL, Walker V, Pai L, Cho LM. Opiates and elderly: use and side effects. Clin Interv Aging. 2008;3:273–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  30. White SM, Rashid N, Chakladar A. An analysis of renal dysfunction in 1511 patients with fractured neck of femur: the implications for peri-operative analgesia. Anaesthesia. 2009;64:1061–5.

    CAS  PubMed  Google Scholar 

  31. •• Abou-Setta AM, Beaupre LA, Rashiq S, Dryden DM, Hamm MP, Sadowski CA, et al. Comparative effectiveness of pain management interventions for hip fracture: a systematic review. Ann Intern Med. 2011;155(4):234–45 *** (systematic review of pain management strategies for hip fracture).

    PubMed  Google Scholar 

  32. Xie S, Xie M. Effect of dexmedetomidine on postoperative delirium in elderly patients undergoing hip fracture surgery. Pak J Pharm Sci. 2018;31(5):2277–81.

    CAS  PubMed  Google Scholar 

  33. •• Soffin EM, Yadeau JT. Enhanced recovery after surgery for primary hip and knee arthroplasty: a review of the evidence. Br J Anaesth. 2016;117:iii62–72. Review of evidence base for constructing ERAS pathways for hip or knee arthroplasty.

    CAS  PubMed  Google Scholar 

  34. Roberts KC, Brox WT. AAOS clinical practice guideline: management of hip fractures in the elderly. J Am Acad Orthop Surg. 2015;23(2):138–40.

    PubMed  Google Scholar 

  35. Rashiq S, Vandermeer B, Abou-Setta AM, Beaupre LA, Jones CA, Dryden DM. Efficacy of supplemental peripheral nerve blockade for hip fracture surgery: multiple treatment comparison. Can J Anesth. 2013;60(3):230–43.

    PubMed  Google Scholar 

  36. •• Morrison RS, Dickman E, Hwang U, Akhtar S, Ferguson T, Huang J, et al. Regional nerve blocks improve pain and functional outcomes in hip fracture: a randomized controlled trial. J Am Geriatr Soc. 2016;64:2433–9 Effects of regional nerve blocks on hip fracture patients.

    PubMed  PubMed Central  Google Scholar 

  37. •• Qiu C, Chan PH, Zohman GL, Prentice HA, Hunt JJ, LaPlace DC, et al. Impact of anesthesia on hospital mortality and morbidity in geriatric patients following emergency hip fracture surgery. J Orthop Trauma. 2018;32(3):116–23 Anesthesia influences on hospital outcomes in elderly hip fracture patients.

    PubMed  Google Scholar 

  38. NYSORA The New York School of Regional Anesthesia. (2018). Ultrasound-guided fascia iliaca block—NYSORA The New York School of Regional Anesthesia. [online] Available at: https://www.nysora.com/ultrasound-guided-fascia-iliaca-block [Accessed 1 Oct. 2018].

  39. Capdevila X, Biboulet P, Bouregba M, Barthelet Y, Rubenovitch J, d'Athis F. Comparison of the three-in-one and fascia iliaca compartment blocks in adults: clinical and radiographic analysis. Anesth Analg. 1998;86(5):1039–44.

    CAS  PubMed  Google Scholar 

  40. Fletcher AK, Rigby AS, Heyes FL. Three-in-one femoral nerve block as analgesia for fractured neck of femur in the emergency department: a randomized, controlled trial. Ann Emerg Med. 2003;41(2):227–33.

    PubMed  Google Scholar 

  41. Beaudoin FL, Haran JP, Liebmann O. A comparison of ultrasound-guided three-in-one femoral nerve block versus parenteral opioids alone for analgesia in emergency department patients with hip fractures: a randomized controlled trial. Acad Emerg Med. 2013;20(6):584–91.

    PubMed  Google Scholar 

  42. Hartmann FV, Novaes MR, de Carvalho MR. Femoral nerve block versus intravenous fentanyl in adult patients with hip fractures—a systematic review. Braz J Anesthesiol. 2017;67(1):67–71.

    PubMed  Google Scholar 

  43. Riddell M, Ospina M, Holroyd-Leduc JM. Use of femoral nerve blocks to manage hip fracture pain among older adults in the emergency department: a systematic review. CJEM. 2016;18(4):245–52.

    PubMed  Google Scholar 

  44. Arsoy D, Gardner M, Amanatullah D, Huddleston J, Goodman S, Maloney W, et al. Continuous femoral nerve catheters decrease opioid-related side effects and increase home disposition rates among geriatric hip fracture patients. J Orthop Trauma. 2017;31(6):e186–9.

    PubMed  Google Scholar 

  45. Grant, S., Martin, G. and Flanagan, E. (2019). Preoperative continuous peripheral nerve blocks in hip fracture patients. [online] Asra.com . Available athttps://www.asra.com/news/120/preoperative-continuous-peripheral-nerve [Accessed 30 Jan. 2019].

  46. Steenberg J, Møller A. (2018). Systematic review of the effects of fascia iliaca compartment block on hip fracture patients before operation. Br J Anaesth. 2018;120(6):1368–80.

    CAS  PubMed  Google Scholar 

  47. Mouzopoulos G, Vasiliadis G, Lasanianos N, Nikolaras G, Morakis E, Kaminaris M. Fascia iliaca block prophylaxis for hip fracture patients at risk for delirium: a randomized placebo-controlled study. J Orthop Traumatol. 2009;10(3):127–33.

    PubMed  PubMed Central  Google Scholar 

  48. Wang X, Sun Y, Wang L, Hao X. Femoral nerve block versus fascia iliaca block for pain control in total knee and hip arthroplasty. Medicine. 2017;96(27):7382.

    Google Scholar 

  49. Reavley P, Montgomery AA, Smith JE, Binks S, Edwards J, Elder G, et al. Randomized trial of the fascia iliaca block versus the ‘3-in-1’ block for femoral neck fractures in the emergency department. Emerg Med J. 2015;32:685–9.

    PubMed  Google Scholar 

  50. Stevens RD, Van Gessel E, Flory N, Fournier R, Gamulin Z. Lumbar plexus block reduces pain and blood loss associated with total hip arthroplasty. Anesthesiology. 2000;93(1):115–21.

    CAS  PubMed  Google Scholar 

  51. Amiri H, Zamani M, Safari S. Lumbar plexus block for management of hip surgeries. Anesth Pain Medicine. 2014;4(3).

  52. Wolff A, Hogan G, Capon J, Napoli A, Smith H, Gaspar P. Pre-operative lumbar plexus block provides superior post-operative analgesia when compared with fascia iliaca block or general anesthesia alone in hip arthroscopy. Orthop J Sports Med. 2016;4(3 suppl 3):2325967116S0006.

    Google Scholar 

  53. Adhikary S, Short A, El-Boghdadly K, Abdelmalak M, Chin K. Transmuscular quadratus lumborum versus lumbar plexus block for total hip arthroplasty: a retrospective propensity score matched cohort study. J Anaesthesiol Clin Pharmacol. 2018;34(3):372–8.

    PubMed  PubMed Central  Google Scholar 

  54. Blanco R. TAP block under ultrasound guidance: the description of a ‘non pops technique’. Reg Anesth Pain Med. 2007;32(supplement 1):130.

    Google Scholar 

  55. La Colla L, Ben-David B, Merman R. Quadratus lumborum block as an alternative to lumbar plexus block for hip surgery: a report of 2 cases. Case Rep. 2017;8:4–6.

    Google Scholar 

  56. La Colla L, Uskova A, Ben-David B. Single-shot quadratus lumborum block for postoperative analgesia after minimally invasive hip arthroplasty: a new alternative to continuous lumbar plexus block? Reg Anesth Pain Med. 2017;42:125–6.

    PubMed  Google Scholar 

  57. Johnston DF, Sondekoppam RV. Continuous quadratus lumborum block analgesia for total hip arthroplasty revision. J Clin Anesth. 2016;35:235–7.

    PubMed  Google Scholar 

  58. Hockett MM, Hembrador S, Lee A. Continuous quadratus lumborum block for postoperative pain in total hip arthroplasty: a case report. Case Rep. 2016;7:129–31.

    Google Scholar 

  59. Ueshima H, Yoshiyama S, Otake H. The ultrasound-guided continuous transmuscular quadratus lumborum block is an effective analgesia for total hip arthroplasty. J Clin Anesth. 2016;31:35.

    PubMed  Google Scholar 

  60. Parras T, Blanco R. Randomised trial comparing the transversus abdominis plane block posterior approach or quadratus lumborum block type I with femoral block for postoperative analgesia in femoral neck fracture, both ultrasound-guided. Rev Esp Anestesiol Reanim. 2016;63:141–8.

    CAS  PubMed  Google Scholar 

  61. Forero M, Adhikary S, Lopez H, Tsui C, Chin K. The erector spinae plane block. Reg Anesth Pain Med. 2016;41(5):621–7.

    CAS  PubMed  Google Scholar 

  62. Hamilton D, Manickam B. Erector spinae plane block for pain relief in rib fractures. Br J Anaesth. 2017;118(3):474–5.

    CAS  PubMed  Google Scholar 

  63. Tulgar S, Selvi O, Senturk O, Ermis M, Cubuk R, Ozer Z. Clinical experiences of ultrasound-guided lumbar erector spinae plane block for hip joint and proximal femur surgeries. J Clin Anesth. 2018;47:5–6.

    PubMed  Google Scholar 

  64. Tulgar S, Senturk O. Ultrasound guided erector spinae plane block at L-4 transverse process level provides effective postoperative analgesia for total hip arthroplasty. J Clin Anesth. 2018;44:68.

    PubMed  Google Scholar 

  65. Bugada D, Zarcone A, Manini M, Lorini L. Continuous erector spinae block at lumbar level (L4) for prolonged postoperative analgesia after hip surgery. J Clin Anesth. 2019;52:24–5.

    PubMed  Google Scholar 

  66. Hadzic’s textbook of regional anesthesia and acute pain management. . New York: McGraw-Hill Medical.(2017)

  67. Foss N, Kristensen M, Kristensen B, Jensen P, Kehlet H. Effect of postoperative epidural analgesia on rehabilitation and pain after hip fracture surgery. Anesthesiology. 2005;102(6):1197–204.

    CAS  PubMed  Google Scholar 

  68. Scheinin H, Virtanen T, Kentala E, Uotila P, Laitio T, Hartiala J, et al. Epidural infusion of bupivacaine and fentanyl reduces perioperative myocardial ischaemia in elderly patients with hip fracture—a randomized controlled trial. Acta Anaesthesiol Scand. 2000;44(9):1061–70.

    CAS  PubMed  Google Scholar 

  69. Coldrey J, Upton R, Macintyre P. Advances in analgesia in the older patient. Best Practice & Research Clin Anaesth. 2011;25(3):367–78.

    CAS  Google Scholar 

  70. Kwan A, Lee B, Brake T. Intrathecal morphine for post-operative analgesia in patients with fractured hips. Hong Kong Med J. 1997;(3):250–5.

  71. Foadi N, Karst M, Frese-Gaul A, Rahe-Meyer N, Krömer S, Weilbach C. The improved quality of postoperative analgesia after intrathecal morphine does not result in improved recovery and quality of life in the first 6 months after orthopedic surgery: a randomized controlled pilot study. J Pain Res. 2017;10:1059–69.

    CAS  PubMed  PubMed Central  Google Scholar 

  72. Cheah J, Sing D, Hansen E, Aleshi P, Vail T. Does intrathecal morphine in spinal anesthesia have a role in modern multimodal analgesia for primary total joint arthroplasty? J Arthroplast. 2018;33(6):1693–8.

    Google Scholar 

  73. Roche JJ, Wenn RT, Sahota O, Moran CG. Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study. BMJ. 2005;331(7529):1374.

    CAS  PubMed  PubMed Central  Google Scholar 

  74. Boddaert J, Raux M, Khiami F, Riou B. Perioperative management of elderly patients with hip fracture. Anesthesiology. 2014;121:1336–41.

    PubMed  Google Scholar 

  75. White SM, Griffiths R, Holloway J, Shannon A. Anaesthesia for proximal femoral fracture in the UK: first report from the NHS Hip Fracture Anaesthesia network. Anaesthesia. 2010;65:243–8.

    CAS  PubMed  Google Scholar 

  76. Siu CW, Sun NC, Lau TW, Yiu KH, Leung F, Tse HF. Preoperative cardiac risk assessment in geriatric patients with hip fractures: an orthopedic surgeons’ perspective. Osteoporos Int. 2010;21(Suppl 4):S587–01.

    CAS  PubMed  Google Scholar 

  77. Barnett SR. Poly-pharmacy and perioperative medications in the elderly. Anesthesiol Clin. 2009;27(3):377–89.

    PubMed  Google Scholar 

  78. Tazarourte K, Riou B, Tremey B, Samama CM, Vicaut E, Vigué B, et al. Guideline-concordant administration of prothrombin complex concentrate and vitamin K is associated with decreased mortality in patients with severe bleeding under vitamin K antagonist treatment (EPAHK study). Crit Care. 2014;18(2):R81.

    PubMed  PubMed Central  Google Scholar 

  79. Albaladejo P, Marret E, Piriou V, Samama CM. French Society of Anesthesiology and Intensive Care: perioperative management of antiplatelet agents in patients with coronary stents: recommendations of a French task force. Br J Anaesth. 2006;97(4):580–28.

    CAS  PubMed  Google Scholar 

  80. Torn M, Frits RR. Oral anticoagulation in surgical procedures: risks and recommendations. Br J Haematol. 2003;123(4):676–82.

    PubMed  Google Scholar 

  81. Miller Ronald D. Chapter 80: Geriatric Anesthesia. Miller’s anesthesia. Elsevier/Saunders, 2015, pp. 2415–2420.

  82. Alvis Bret D. Physiologic considerations in the geriatric patient. Anesthesiol Clin. 2015;33(3):447–56.

    CAS  PubMed  PubMed Central  Google Scholar 

  83. Turrentine FE, Wang H, Simpson VB, Jones RS. Surgical risk factors, morbidity and mortality in elderly patients. J Am Coll Surg. 2006;203(6):865–77.

    PubMed  Google Scholar 

  84. Sciard D, Cattano D, Hussain M, Rosenstein A. Perioperative management of proximal hip fractures in the elderly: the surgeon and the anesthesiologist. Minerva Anesthesiol. 2011;77(7):715–22.

    CAS  Google Scholar 

  85. Benson EE, McMillan DE, Ong B. The effects of active warming on patient temperature and pain after total knee arthroplasty. Am J Nurs. 2012;112:26–33.

    PubMed  Google Scholar 

  86. Bernard AC, Davenport DL, Chang PK, Vaughan TB, Zwischenberger JB. Intraoperative transfusion of 1U to 2U packed red blood cells is associated with increased 30-day mortality, surgical-site infection, pneumonia, and sepsis in general surgery patients. J Am Coll Surg. 2009;208:931–7.

    PubMed  Google Scholar 

  87. Farrow LS, Smith TO, Ashcroft GP, Myint PK. A systematic review of tranexamic acid in hip fracture surgery. Br J Clin Pharmacol. 2016;82(6):1458–70.

    CAS  PubMed  PubMed Central  Google Scholar 

  88. Neuman MD, Silber JH, Elkassabany NM, Ludwig JM, Fleisher LA. Comparative effectiveness of regional versus general anesthesia for hip fracture surgery in adults. Anesthesiology. 2012;117:72–92.

    CAS  PubMed  Google Scholar 

  89. Guo Y, Peiyu J, Junfeng Z, Xuemin W, Hong J, Wei J. Prevalence and risk factors of postoperative delirium in elderly hip fracture patients. J Int Med Res. 2016;44(2):317–27.

    CAS  PubMed  PubMed Central  Google Scholar 

  90. Abildstrom H, Rasmussen LS, Rentowl P, Hanning CD, Rasmussen H, Kristensen PA, et al. Cognitive dysfunction 1–2 years after non-cardiac surgery in the elderly. ISPOCD group: International Study of Post-operative Cognitive Dysfunction. Acta Anaesthesiol Scand. 2000;44(1):1246–51.

  91. Gibson AA, Hay AW, Ray DC. Patients with hip fracture admitted to critical care: epidemiology, interventions and outcome. Injury. 2014;45(7):1066–70.

    PubMed  Google Scholar 

  92. Waesberghe JV, Stevanovic A, Rossaint R, Coburn M. General vs. neuraxial anaesthesia in hip fracture patients: a systematic review and meta-analysis. BMC Anesthesiol. 2017;17(1):87.

    PubMed  PubMed Central  Google Scholar 

  93. Maxwell L, White S. Anaesthetic management of patients with hip fractures: an update. Continuing Education in Anaesthesia Critical Care & Pain. 2013;13(5):179–83.

    Google Scholar 

  94. Urwin SC, Parker MK, Griffiths R. General versus regional anaesthesia for hip fracture surgery: a meta-analysis of randomized trials. Br J Anaesth. 2000;84(4):450–5.

    CAS  PubMed  Google Scholar 

  95. Scottish Intercollegiate Guidelines Network. Management of hip fracture in older people. Edinburgh, Scotland: Scottish Intercollegiate Guidelines Network; 2009.

    Google Scholar 

  96. UK National Clinical Guideline Centre. The management of hip fracture in adults. UK National Clinical Guideline Centre, London, England: 2011.

  97. O’Donnell CM, McLoughlin L, Patterson CC, Clarke M, McCourt KC, McBrien ME, et al. Perioperative outcomes in the context of mode of anaesthesia for patients undergoing hip fracture surgery: systematic review and meta-analysis. Br J Anaesth. 2018;120(1):37–50.

  98. Bang SR, Ahn EJ, Kim HJ, Kim KW et al. General anesthesia versus regional anesthesia in mortality and delirium of elderly hip fracture patients: a nationwide population-based study. Abstract: 5222, 2018 World Congress on Regional Anesthesia & Pain Medicine.

  99. Basques BA, Bohl DD, Golinvaux NS, Samuel AM, Grauer JG. General versus spinal anaesthesia for patients aged 70 years and older with a fracture of the hip. Bone joint J. 2015;97-B(5):689–95.

    CAS  PubMed  Google Scholar 

  100. Fields AC, Dieterich JD, Buterbaugh K, Moucha CS. Short-term complications in hip fracture surgery using spinal versus general anesthesia. Injury. 2015:46719–23, 46, 719.

  101. Shih YJ, Hsieh CH, Kang TW, Peng SY, Fan KT, Wang LM. General versus spinal anesthesia: which is a risk factor for octogenarian hip fracture repair patients? Int J Gerontol. 2010;4:37–42.

    Google Scholar 

  102. Seitz DP, Gill SS, Bell CM, Austin PC, Gruneir A, Anderson G, et al. A postoperative medical complications associated with anesthesia on older adults with dementia. J Am Geriatr Soc. 2014;62:2102–9.

    PubMed  Google Scholar 

  103. Whitting PS, Molina CS, Greenberg SE, Thakore RV, Obremskey WT, Sethi MK. Regional anaesthesia for hip fracture surgery is associated with significantly more peri-operative complications compared with general anaesthesia. Int Orthop. 2015;39:1321–7.

    Google Scholar 

  104. Tung YC, Hsu YH, Chang GM. The effect of anesthetic type on outcomes of hip fracture surgery: a nationwide population-based study. Medicine (Baltimore). 2016;95(14):e3296.

    CAS  Google Scholar 

  105. Guay J, Parker MJ, Gajendragadkar PR, Kopp S. Anaesthesia for hip fracture surgery in adults. Cochrane Database Syst Rev. 2016;2.

  106. Memtsoudis SG, Sun X, Chiu YL, Stundner O, Liu SS, Banerjee S, et al. Perioperative comparative effectiveness of anesthetic technique in orthopedic patients. Anesthesiology. 2013;118(5):1046–58.

    PubMed  Google Scholar 

  107. Liu J, Ma C, Elkassabany N, Fleisher LA, Neuman MD. Neuraxial anesthesia decreases postoperative systemic infection risk compared with general anesthesia in knee arthroplasty. Anesth Analg. 2013;117(4):1010–6.

    PubMed  PubMed Central  Google Scholar 

  108. Van Allen NR, Kraftt RP, Leitzke AS, Applegate RL II, Tang J, Zhang JH. The role of volatile anesthetics in cardioprotection: a systematic review. Med Gas Res. 2012;2(1):22.

    PubMed  PubMed Central  Google Scholar 

  109. Helwani MA, Avidan MS, Ben Abdallah A, Kaiser DJ, Chohisy JC, Hall BL, et al. Effects of regional versus general anesthesia on outcomes after total hip arthroplasty. A retrospective propensity-matched cohort study. J Bone Joint Surg Am. 2015;97(3):186–93.

    PubMed  Google Scholar 

  110. Kim SD, Park SJ, Lee DH, Jee DL. Risk factors of morbidity and mortality following hip fracture surgery. Korean J Anesthesiol. 2013;64(6):505–10.

    PubMed  PubMed Central  Google Scholar 

  111. Heidari SM, Soltani H, Hashemi SJ, Talakoub R, Soleimani B. Comparative study of two anaesthesia methods according to postoperative complications and one month mortality rate in the candidates of hip surgery. Journal of Research in Medical Sciences. 2011;16(3):323–30.

    PubMed  PubMed Central  Google Scholar 

  112. Patel V, Champaneria R, Dretzke J, Yeung J. Effect of regional versus general anaesthesia on postoperative delirium in elderly patients undergoing surgery for hip fracture: a systematic review. BMJ Open. 2018;8(12):e020757.

    PubMed  PubMed Central  Google Scholar 

  113. Luger TJ, Kammerlander C, Gosch M, Luger MF, Kammerlander-Knauer U, Roth T, et al. Neuroaxial versus general anaesthesia in geriatric patients for hip fracture surgery: does it matter? Osteoporos Int. 2010;21(suppl4):555–72.

    CAS  Google Scholar 

  114. Marcantonio ER, Flacker JM, Michaels M, Resnick NM. Delirium is independently associated with poor functional recovery after hip fracture. J Am Geriatr Soc. 2000;48(6):618–24.

    CAS  PubMed  Google Scholar 

  115. McCusker J, Cole M, Abrahamowicz M, Primeau F, Belzile E. Delirium predicts 12-month mortality. Arch Intern Med. 2002 Feb; 25;162(4):457–63.

    PubMed  Google Scholar 

  116. Furlaneto ME, Garcez-Leme LE. Impact of delirium on mortality and cognitive and functional performance among elderly people with femoral fractures. Clinics (Sao Paolo). 2007;62(5):545–52.

    Google Scholar 

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Correspondence to Karina Gritsenko.

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A.D., F.F., J.D., S.S., A.B., M.K., and K.G. declare no conflict of interest. A.D.K. discloses that he is on the Speakers Bureau for Depomed, Inc. and Merck.

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Dizdarevic, A., Farah, F., Ding, J. et al. A Comprehensive Review of Analgesia and Pain Modalities in Hip Fracture Pathogenesis. Curr Pain Headache Rep 23, 72 (2019). https://doi.org/10.1007/s11916-019-0814-9

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