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Cancer Treatment-Related Neuropathic Pain Syndromes—Epidemiology and Treatment: An Update

  • Neuropathic Pain (E Eisenberg, Section Editor)
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Abstract

Cancer treatment-related chronic neuropathic pain (NP) is a pervasive and distressing problem that negatively influences function and quality of life for countless cancer survivors. It occurs because of cancer treatment-induced damage to peripheral and central nervous system structures. NP becomes chronic when pain signal transmission persists, eventually sensitizing neurons in the dorsal horn and other pain-processing regions in the central nervous system. Frequently overlooked, NP due to cancer treatment has been understudied. Consequently, only a few pharmacologic interventions have been shown to be effective based on the results of randomized controlled trials. Future research designed to explore pathophysiologic mechanisms and effective mechanism-targeted interventions is sorely needed.

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References

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  1. American Cancer Society. Cancer facts and figures 2014. American Cancer Society Cancer Facts and Figures 2014 Web site. Available at: http://www.cancer.org/acs/groups/content/@research/documents/webcontent/acspc-042151.pdf. Published 2014. Updated 2014. Accessed March 26, 2014.

  2. Fisch MJ, Lee JW, Weiss M, et al. Prospective, observational study of pain and analgesic prescribing in medical oncology outpatients with breast, colorectal, lung, or prostate cancer. J Clin Oncol. 2012;30:1980–8.

    Article  PubMed  PubMed Central  Google Scholar 

  3. van den Beuken-van Everdingen MH, de Rijke JM, Kessels AG, Schouten HC, van Kleef M, Patijn J. Prevalence of pain in patients with cancer: a systematic review of the past 40 years. Ann Oncol. 2007;18:1437–49.

    Article  PubMed  Google Scholar 

  4. Goudas LC, Bloch R, Gialeli-Goudas M, Lau J, Carr DB. The epidemiology of cancer pain. Cancer Investig. 2005;23:182–90.

    Article  Google Scholar 

  5. Bennett MI, Rayment C, Hjermstad M, Aass N, Caraceni A, Kaasa S. Prevalence and aetiology of neuropathic pain in cancer patients: a systematic review. Pain. 2012;153:359–65. A systematic review of 22 eligible studies that included a total of 13,683 patients with cancer to determine NP prevalence.

    Article  PubMed  Google Scholar 

  6. Rayment C, Hjermstad MJ, Aass N, et al. Neuropathic cancer pain: prevalence, severity, analgesics and impact from the European palliative care research collaborative-computerised symptom assessment study. Palliat Med. 2013;27:714–21.

    Article  PubMed  Google Scholar 

  7. Moore RA, Derry S, Taylor RS, Straube S, Phillips CJ. The costs and consequences of adequately managed chronic non-cancer pain and chronic neuropathic pain. Pain Pract. 2014;14:79–94.

    Article  Google Scholar 

  8. International Association for the Study of Pain (IASP). Pain terminology. Available at: http://www.iasp-pain.org/AM/Template.cfm?Section=General_Resource_Links&Template=/CM/HTMLDisplay.cfm&ContentID=3058#Pain. Updated 2008. Accessed June 24, 2014.

  9. Baron R, Binder A, Wasner G. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol. 2010;9:807–19. Provides a comprehensive description of neuropathic pain mechanisms and treatment with informative illustrations.

    Article  PubMed  Google Scholar 

  10. Tracey I, Bushnell MC. How neuroimaging studies have challenged us to rethink: is chronic pain a disease? J Pain. 2009;10:1113–20.

    Article  PubMed  Google Scholar 

  11. Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011;152(3 Suppl):S2–S15.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Diatchenko L, Nackley AG, Slade GD, Fillingim RB, Maixner W. Idiopathic pain disorders—pathways of vulnerability. Pain. 2006;123:226–30.

    Article  PubMed  Google Scholar 

  13. Willis WD, Westlund KN. Neuroanatomy of the pain system and of the pathways that modulate pain. J Clin Neurophysiol. 1997;14:2–31.

    Article  PubMed  CAS  Google Scholar 

  14. Miaskowski C, Paul SM, Cooper B, et al. Identification of patient subgroups and risk factors for persistent arm/shoulder pain following breast cancer surgery. Eur J Oncol Nurs. 2014;18:242–53.

    Article  PubMed  Google Scholar 

  15. Bruce J, Thornton AJ, Powell R, et al. Psychological, surgical, and sociodemographic predictors of pain outcomes after breast cancer surgery: a population-based cohort study. Pain. 2014;155:232–43. An important prospective cohort study identifying key predictors of chronic NP following breast cancer treatment.

    Article  PubMed  Google Scholar 

  16. Brummett CM. Chronic pain following breast surgery. Tech Reg Anesth Pain Manag. 2011;15:124–32.

    Article  Google Scholar 

  17. Gartner R, Jensen MB, Nielsen J, Ewertz M, Kroman N, Kehlet H. Prevalence of and factors associated with persistent pain following breast cancer surgery. JAMA. 2009;302:1985–92.

    Article  PubMed  Google Scholar 

  18. Hinrichs-Rocker A, Schulz K, Jarvinen I, Lefering R, Simanski C, Neugebauer EA. Psychosocial predictors and correlates for chronic post-surgical pain (CPSP) - a systematic review. Eur J Pain. 2009;13:719–30.

    Article  PubMed  Google Scholar 

  19. Lundstedt D, Gustafsson M, Malmström P, et al. Symptoms 10–17 years after breast cancer radiotherapy data from the randomised SWEBCG91-RT trial. Radiother Oncol. 2010;97:281–7.

    Article  PubMed  Google Scholar 

  20. Johansson S, Svensson H, Larsson LG, Denekamp J. Brachial plexopathy after postoperative radiotherapy of breast cancer patients—a long-term follow-up. Acta Oncol. 2000;39:373–82.

    Article  PubMed  CAS  Google Scholar 

  21. Chen PY, Wallace M, Mitchell C, et al. Four-year efficacy, cosmesis, and toxicity using three-dimensional conformal external beam radiation therapy to deliver accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys. 2010;76:991–7.

    Article  PubMed  Google Scholar 

  22. Manas A, Monroy JL, Ramos AA, et al. Prevalence of neuropathic pain in radiotherapy oncology units. Int J Radiat Oncol Biol Phys. 2011;81:511–20.

    Article  PubMed  Google Scholar 

  23. Forquer JA, Fakiris AJ, Timmerman RD, et al. Brachial plexopathy from stereotactic body radiotherapy in early-stage NSCLC: dose-limiting toxicity in apical tumor sites. Radiother Oncol. 2009;93:408–13.

    Article  PubMed  Google Scholar 

  24. Nissenbaum J, Devor M, Seltzer Z, et al. Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2. Genome Res. 2010;20:1180–90.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  25. Sheridan D, Foo I, O'Shea H, et al. Long-term follow-up of pain and emotional characteristics of women after surgery for breast cancer. J Pain Symptom Manag. 2012;44:608–14.

    Article  Google Scholar 

  26. Pielsticker A, Haag G, Zaudig M, Lautenbacher S. Impairment of pain inhibition in chronic tension-type headache. Pain. 2005;118:215–23.

    Article  PubMed  Google Scholar 

  27. Julien N, Goffaux P, Arsenault P, Marchand S. Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition. Pain. 2005;114:295–302.

    Article  PubMed  Google Scholar 

  28. Kosek E, Hansson P. Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects. Pain. 1997;70:41–51.

    Article  PubMed  CAS  Google Scholar 

  29. Yarnitsky D, Crispel Y, Eisenberg E, et al. Prediction of chronic post-operative pain: pre-operative DNIC testing identifies patients at risk. Pain. 2008;138:22.

    Article  PubMed  Google Scholar 

  30. Yarnitsky D. Conditioned pain modulation (the diffuse noxious inhibitory control-like effect): its relevance for acute and chronic pain states. Curr Opin Anaesthesiol. 2010;23:611–5.

    Article  PubMed  Google Scholar 

  31. Weissman-Fogel I, Granovsky Y, Crispel Y, et al. Enhanced presurgical pain temporal summation response predicts post-thoracotomy pain intensity during the acute postoperative phase. J Pain. 2009;10:628–36.

    Article  PubMed  Google Scholar 

  32. Edwards RR, Ness TJ, Weigent DA, Fillingim RB. Individual differences in diffuse noxious inhibitory controls (DNIC): association with clinical variables. Pain. 2003;106:427–37.

    Article  PubMed  Google Scholar 

  33. Campbell CM, Edwards RR. Mind-body interactions in pain: the neurophysiology of anxious and catastrophic pain-related thoughts. Transl Res J Labor Clin Med. 2009;153:97–101.

    Article  Google Scholar 

  34. Edwards RR, Calahan C, Mensing G, Smith M, Haythornthwaite JA. Pain, catastrophizing, and depression in the rheumatic diseases. Nat Rev Rheumatol. 2011;7:216–24.

    Article  PubMed  CAS  Google Scholar 

  35. Edwards RR, Bingham III CO, Bathon J, Haythornthwaite JA. Catastrophizing and pain in arthritis, fibromyalgia, and other rheumatic diseases. Arthritis Rheum. 2006;55:325–32.

    Article  PubMed  Google Scholar 

  36. Sullivan MJ, Thorn B, Haythornthwaite JA, et al. Theoretical perspectives on the relation between catastrophizing and pain. Clin J Pain. 2001;17:52–64.

    Article  PubMed  CAS  Google Scholar 

  37. Pavlin DJ, Sullivan MJ, Freund PR, Roesen K. Catastrophizing: a risk factor for postsurgical pain. Clin J Pain. 2005;21:83–90.

    Article  PubMed  Google Scholar 

  38. Jacobsen PB, Butler RW. Relation of cognitive coping and catastrophizing to acute pain and analgesic use following breast cancer surgery. J Behav Med. 1996;19:17–29.

    Article  PubMed  CAS  Google Scholar 

  39. Theunissen M, Peters ML, Bruce J, Gramke HF, Marcus MA. Preoperative anxiety and catastrophizing: a systematic review and meta-analysis of the association with chronic postsurgical pain. Clin J Pain. 2012;9:819–41.

    Article  Google Scholar 

  40. Masselin-Dubois A, Attal N, Fletcher D, et al. Are psychological predictors of chronic postsurgical pain dependent on the surgical model? A comparison of total knee arthroplasty and breast surgery for cancer. J Pain. 2013;14:854–64.

    Article  PubMed  Google Scholar 

  41. Turner JA, Jensen MP, Romano JM. Do beliefs, coping, and catastrophizing independently predict functioning in patients with chronic pain? Pain. 2000;85:115–25.

    Article  PubMed  CAS  Google Scholar 

  42. Crisson JE, Keefe FJ. The relationship of locus of control to pain coping strategies and psychological distress in chronic pain patients. Pain. 1988;35:147–54.

    Article  PubMed  CAS  Google Scholar 

  43. Strong J, Cramond T. Pain intensity, attitude and function in back pain patients. Pain. 1990;41:S499.

    Article  Google Scholar 

  44. Powell R, Johnston M, Smith WC, et al. Psychological risk factors for chronic post-surgical pain after inguinal hernia repair surgery: a prospective cohort study. Eur J Pain. 2012;16:600–10.

    Article  PubMed  CAS  Google Scholar 

  45. Raphael KG, Widom CS. Post-traumatic stress disorder moderates the relation between documented childhood victimization and pain 30 years later. Pain. 2011;152:163–9.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Humphreys J, Cooper BA, Miaskowski C. Differences in depression, posttraumatic stress disorder, and lifetime trauma exposure in formerly abused women with mild vs moderate to severe chronic pain. J Interpers Violence. 2010;25:2316–38.

    Article  PubMed  Google Scholar 

  47. Barry DT, Beitel M, Cutter CJ, et al. Exploring relations among traumatic, posttraumatic, and physical pain experiences in methadone-maintained patients. J Pain. 2011;12:22–8.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Baccini F, Pallotta N, Calabrese E, Pezzotti P, Corazziari E. Prevalence of sexual and physical abuse and its relationship with symptom manifestations in patients with chronic organic and functional gastrointestinal disorders. Dig Liver Dis. 2003;35:256–61.

    Article  PubMed  CAS  Google Scholar 

  49. Meltzer-Brody S, Leserman J, Zolnoun D, Steege J, Green E, Teich A. Trauma and posttraumatic stress disorder in women with chronic pelvic pain. Obstet Gynecol. 2007;109:902–8.

    Article  PubMed  Google Scholar 

  50. Golding JM. Sexual assault history and headache: five general population studies. J Nerv Ment Dis. 1999;187:624–9.

    Article  PubMed  CAS  Google Scholar 

  51. Campbell JC, Lewandowski LA. Mental and physical health effects of intimate partner violence on women and children. Psychiatr Clin N Am. 1997;20:353–74.

    Article  CAS  Google Scholar 

  52. Coker AL, Smith PH, Bethea L, King MR, McKeown RE. Physical health consequences of physical and psychological intimate partner violence. Arch Fam Med. 2000;9:451–7.

    Article  PubMed  CAS  Google Scholar 

  53. Ducic I, Zakaria HM, Felder JM III, Fantus S. Nerve injuries in aesthetic breast surgery: systematic review and treatment options. Aesthet Surg J. 2014.

  54. Poleshuck EL, Katz J, Andrus CH, et al. Risk factors for chronic pain following breast cancer surgery: a prospective study. J Pain. 2006;7:626–34.

    Article  PubMed  Google Scholar 

  55. Andersen KG, Kehlet H. Persistent pain after breast cancer treatment: a critical review of risk factors and strategies for prevention. J Pain. 2011;12:725–46. A systematic review of 60 studies describing predictors of chronic pain after breast cancer.

    Article  PubMed  Google Scholar 

  56. Vilholm OJ, Cold S, Rasmussen L, Sindrup SH. The postmastectomy pain syndrome: an epidemiological study on the prevalence of chronic pain after surgery for breast cancer. Br J Cancer. 2008;99:604–10.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  57. Gahm J, Wickman M, Brandberg Y. Bilateral prophylactic mastectomy in women with inherited risk of breast cancer—prevalence of pain and discomfort, impact on sexuality, quality of life and feelings of regret two years after surgery. Breast. 2010;19:462–9.

    Article  PubMed  Google Scholar 

  58. Bayman EO, Brennan TJ. Incidence and severity of chronic pain at 3 and 6 months after thoracotomy: meta-analyses. J Pain. 2014;15(9):887–897. A rigorously conducted systematic review/meta-analysis of 22 studies to assess the incidence and severity of chronic pain at 3 and 6 months after thoracotomy.

  59. Hill A. Phantom limb pain: a review of the literature on attributes and potential mechanisms. J Pain Symptom Manag. 1999;17:125–42.

    Article  CAS  Google Scholar 

  60. Prantl L, Schreml S, Heine N, Eisenmann-Klein M, Angele P. Surgical treatment of chronic phantom limb sensation and limb pain after lower limb amputation. Plast Reconstr Surg. 2006;118:1562–72.

    Article  PubMed  CAS  Google Scholar 

  61. van Wilgen CP, Dijkstra PU, van der Laan BF, Plukker JT, Roodenburg JL. Morbidity of the neck after head and neck cancer therapy. Head Neck. 2004;26:785–91.

    Article  PubMed  Google Scholar 

  62. Polomano RC, Farrar JT. Pain and neuropathy in cancer survivors. Cancer Nurs. 2006;29:39.

    Article  PubMed  Google Scholar 

  63. Pignol JP, Olivotto I, Rakovitch E, et al. A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol. 2008;26:2085–92.

    Article  PubMed  Google Scholar 

  64. Vicini FA, Chen P, Wallace M, et al. Interim cosmetic results and toxicity using 3D conformal external beam radiotherapy to deliver accelerated partial breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys. 2007;69:1124–30.

    Article  PubMed  Google Scholar 

  65. Inomata T, Narabayashi I, Inada Y, et al. Patients’ subjective evaluation of early and late sequelae in patients with breast cancer irradiated with short fractionation for breast conservation therapy: comparison with conventional fractionation. Breast Cancer. 2008;15:93–100.

    Article  PubMed  Google Scholar 

  66. Dodd MJ, Cho MH, Cooper BA, Miaskowski C. The effect of symptom clusters on functional status and quality of life in women with breast cancer. Eur J Oncol Nurs. 2010;14:101–10.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Ebbeskov Lauritsen L, Meidahl Petersen P, Daugaard G. Neurological adverse effects after radiation therapy for stage II seminoma. Case Rep Oncol. 2012;5:444–8.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Kirkpatrick JP, van der Kogel AJ, Schultheiss TE. Radiation dose-volume effects in the spinal cord. Int J Radiat Oncol Biol Phys. 2010;76(3 Suppl):S42–9.

    Article  PubMed  Google Scholar 

  69. Hausheer FH, Schilsky RL, Bain S, Berghorn EJ, Lieberman F. Diagnosis, management, and evaluation of chemotherapy-induced peripheral neuropathy. Semin Oncol. 2006;33:15–49.

    Article  PubMed  CAS  Google Scholar 

  70. Kautio AL, Haanpaa M, Kautiainen H, Kalso E, Saarto T. Burden of chemotherapy-induced neuropathy—a cross-sectional study. Support Care Cancer. 2011;19:1991–6.

    Article  PubMed  Google Scholar 

  71. Argyriou AA, Bruna J, Marmiroli P, Cavaletti G. Chemotherapy-induced peripheral neurotoxicity (CIPN): an update. Crit Rev Oncol Hematol. 2012;82:51–77.

    Article  PubMed  Google Scholar 

  72. Gutierrez-Gutierrez G, Sereno M, Miralles A, Casado-Saenz E, Gutierrez-Rivas E. Chemotherapy-induced peripheral neuropathy: clinical features, diagnosis, prevention and treatment strategies. Clin Transl Oncol. 2010;12:81–91.

    Article  PubMed  Google Scholar 

  73. Windebank AJ, Grisold W. Chemotherapy-induced neuropathy. J Periph Nerv Syst. 2008;13:27–46.

    Article  CAS  Google Scholar 

  74. Smith EM, Cohen JA, Pett MA, Beck SL. The reliability and validity of a modified total neuropathy score-reduced and neuropathic pain severity items when used to measure chemotherapy-induced peripheral neuropathy in patients receiving taxanes and platinums. Cancer Nurs. 2010;33:173–83.

    Article  PubMed  Google Scholar 

  75. Loprinzi CL, Reeves BN, Dakhil SR, et al. Natural history of paclitaxel-associated acute pain syndrome: prospective cohort study NCCTG N08C1. J Clin Oncol. 2011;29:1472–8.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  76. Wampler MA, Miaskowski C, Hamel K, Byl N, Rugo H, Topp LS. The modified total neuropathy score: a clinically feasible and valid measure of taxane-induced peripheral neuropathy in women with breast cancer. Support Oncol. 2006;4:W9–W16.

    Google Scholar 

  77. Anonymous. Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer. the elderly lung cancer vinorelbine Italian study group. J Natl Cancer Inst. 1999;91:66–72.

  78. Smith EM, Pang H, Cirrincione C, et al. Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. JAMA. 2013;309:1359–67. The only large RCT published to date supporting the use of an effective intervention for painful chemotherapy-induced peripheral neuropathy.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  79. Mao JJ, Stricker C, Bruner D, et al. Patterns and risk factors associated with aromatase inhibitor-related arthralgia among breast cancer survivors. Cancer. 2009;115:3631–9.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  80. Smith E, Bakitas MA, Homel P, et al. Using quality improvement methodology to improve neuropathic pain screening and assessment in patients with cancer. J Cancer Educ. 2009;24:135–40.

    Article  Google Scholar 

  81. Haanpaa M, Attal N, Backonja M, et al. NeuPSIG guidelines on neuropathic pain assessment. Pain. 2011;152:14–27.

    Article  PubMed  Google Scholar 

  82. Cruccu G, Sommer C, Anand P, et al. EFNS guidelines on neuropathic pain assessment: revised 2009. Eur J Neurol. 2010;17:1010–8.

    Article  PubMed  CAS  Google Scholar 

  83. Jongen JL, Huijsman ML, Jessurun J, et al. The evidence for pharmacologic treatment of neuropathic cancer pain: beneficial and adverse effects. J Pain Symp Manag. 2013;46:581–90.e1.

    Article  Google Scholar 

  84. Dworkin R, O'Connor A, Backonja M, et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain. 2007;132:237.

    Article  PubMed  CAS  Google Scholar 

  85. Attal N, Cruccu G, Baron R, et al. EFNS guidelines on the pharmacologic treatment of neuropathic pain: 2010 revision. Eur J Neurol. 2010;17:1113–e88.

    Article  PubMed  CAS  Google Scholar 

  86. Moulin DE, Clark AJ, Gilron I, et al. Pharmacologic management of chronic neuropathic pain - consensus statement and guidelines from the Canadian pain society. Pain Res Manag: J Can Pain Soc. 2007;12:13.

    CAS  Google Scholar 

  87. Dworkin RH, Backonja M, Rowbotham MC, et al. Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations.[see comment]. [review] [70 refs]. Arch Neurol. 2003;60:1524–34.

    Article  PubMed  Google Scholar 

  88. Dworkin RH, O'Connor AB, Audette J, et al. Recommendations for the pharmacologic management of neuropathic pain: an overview and literature update. Mayo Clin Proc. 2010;85(3 Suppl):S3–S14.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  89. Finnerup N, Otto M, Jensen T, Sindrup S. An evidence-based algorithm for the treatment of neuropathic pain. MedGenMed. 2007;9:36.

    PubMed  PubMed Central  Google Scholar 

  90. Finnerup NB, Sindrup SH, Jensen TS. The evidence for pharmacologic treatment of neuropathic pain. Pain. 2010;150:573–81.

    Article  PubMed  Google Scholar 

  91. Amr YM, Yousef AA. Evaluation of efficacy of the perioperative administration of venlafaxine or gabapentin on acute and chronic postmastectomy pain. Clin J Pain. 2010;26:381–5. A RCT supporting the use of an effective intervention to prevent breast cancer surgery-related NP.

    Article  PubMed  Google Scholar 

  92. Tasmuth T, Hartel B, Kalso E. Venlafaxine in neuropathic pain following treatment of breast cancer. Eur J Pain. 2002;6:17–24.

    Article  PubMed  CAS  Google Scholar 

  93. Strazisar B, Besic N. Comparison of continuous local anaesthetic and systemic pain treatment after axillary lymphadenectomy in breast carcinoma patients - a prospective randomized study. Radiol Oncol. 2013;47:145–53.

    Article  PubMed  PubMed Central  Google Scholar 

  94. Pud D, Eisenberg E, Spitzer A, Adler R, Fried G, Yarnitsky D. The NMDA receptor antagonist amantadine reduces surgical neuropathic pain in cancer patients: a double blind, randomized, placebo controlled trial. Pain. 1998;75:349–54.

    Article  PubMed  CAS  Google Scholar 

  95. Ellison N, Loprinzi CL, Kugler J, et al. Phase III placebo-controlled trial of capsaicin cream in the management of surgical neuropathic pain in cancer patients. J Clin Oncol. 1997;15:2974–80.

    PubMed  CAS  Google Scholar 

  96. Kalso E, Tasmuth T, Neuvonen PJ. Amitriptyline effectively relieves neuropathic pain following treatment of breast cancer. Pain. 1996;64:293–302.

    Article  PubMed  CAS  Google Scholar 

  97. Hershman DL, Lacchetti C, Dworkin RH, et al. Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2014. A recently published clinical practice guideline based on a systematic review of 48 RCTS testing interventions to prevent or treat CIPN.

  98. Rao RD, Michalak JC, Sloan JA, et al. Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled, crossover trial (N00C3). Cancer. 2007;110:2110–8.

    Article  PubMed  CAS  Google Scholar 

  99. Hammack JE, Michalak JC, Loprinzi CL, et al. Phase III evaluation of nortriptyline for alleviation of symptoms of cis-platinum-induced peripheral neuropathy. Pain. 2002;98:195–203.

    Article  PubMed  CAS  Google Scholar 

  100. Barton DL, Wos EJ, Qin R, et al. A double-blind, placebo-controlled trial of a topical treatment for chemotherapy-induced peripheral neuropathy: NCCTG trial N06CA. Supp Care Cancer. 2011;19:833–41.

    Article  Google Scholar 

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Ellen M. Lavoie Smith, Celia M. Bridges, Grace Kanzawa, Robert Knoerl, James P. Kelly IV, Anna Berezovsky, and Charis Woo declare that they have no potential conflicts of interest.

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  1. University of Michigan School of Nursing, Ann Arbor, MI, 48109, USA

    Ellen M. Lavoie Smith, Celia M. Bridges, Grace Kanzawa, Robert Knoerl & Charis Woo

  2. University of Michigan, Ann Arbor, MI, 48109, USA

    James P. Kelly IV & Anna Berezovsky

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Smith, E.M.L., Bridges, C.M., Kanzawa, G. et al. Cancer Treatment-Related Neuropathic Pain Syndromes—Epidemiology and Treatment: An Update. Curr Pain Headache Rep 18, 459 (2014). https://doi.org/10.1007/s11916-014-0459-7

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