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Cognitive processing in cluster headache

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Abstract

Little is known about specific changes of cognitive processing in cluster headache. Studies on event-related potentials (ERP) suggest that stimulus evaluation is impaired in chronic cluster headache and in episodic cluster headache during the cluster period, but not in the interval between two periods. Patients with chronic paroxysmal hemicrania do not show this impairment. Unlike patients with migraine, patients with cluster headache do not present with a loss of cognitive habituation as measured by ERP. In neuropsychologic evaluations, a reversible decline of memory processing was detected during the cluster attack, but not between two attacks. Long-term observation revealed no progressive cognitive decline in cluster headache patients over the years. With regard to personality changes, a liability susceptibility to anxiety disorders and to hypochondriasis, but not to mood changes, has been described inconsistently. All changes in alterations of cognitive processing in cluster headache are demonstrated to be mild and do not relevantly contribute to the clinical picture of this disease.

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References and Recommended Reading

  1. Lozza A, Schoenen J, Delwaide PJ: Inhibition of the blink reflex R2 component after supraorbital and index finger stimulations is reduced in cluster headache: an indication for both segmental and suprasegmental dysfunction? Pain 1997, 71:81–88.

    Article  PubMed  CAS  Google Scholar 

  2. Hsieh JC, Hannerz J, Ingvar M: Right-lateralized central processing for pain of nitroglycerin-induced cluster headache. Pain 1996, 67:59–68.

    Article  PubMed  CAS  Google Scholar 

  3. May A, Bahra A, Büchel C, et al.: Hypothalamic activation in cluster headache attacks. Lancet 1998, 352:275–278.

    Article  PubMed  CAS  Google Scholar 

  4. Leone M, Bussone G: A review of hormonal findings in cluster headache: evidence for hypothalamic involvement. Cephalalgia 1993, 13:309–337.

    Article  PubMed  CAS  Google Scholar 

  5. Strittmatter M, Hamann GF, Grauer M, et al.: Altered activity of the sympathetic nervous system and changes in the balance of hypophyseal, pituitary and adrenal hormones in patients with cluster headache. Neuroreport 1996, 17:1229–1234.

    Article  Google Scholar 

  6. May A, Leone M: Update on cluster headache. Curr Opin Neurol 2003, 16:333–340. An excellent review of all of the modern aspects of cluster headache.

    Article  PubMed  Google Scholar 

  7. May A, Bahra A, Büchel C, et al.: PET and MRA findings in cluster headache and MRA in experimental pain. Neurology 2000, 55:1328–1335.

    PubMed  CAS  Google Scholar 

  8. Franzini A, Ferroli P, Leone M, Broggi G: Stimulation of the posterior hypothalamus for treatment of chronic intractable cluster headaches: first reported series. Neurosurgery 2003, 52:1095–1099. A very innovative paper on the possibility of treating cluster headache by stimulation of the hypothalamus.

    Article  PubMed  Google Scholar 

  9. Boiardi A, Carenini L, Frediani F, et al.: Visual evoked potentials in cluster headache: central structures involvement. Headache 1986, 26:70–73.

    Article  PubMed  CAS  Google Scholar 

  10. Polich J, Aung M, Dalessio DJ: Pattern-shift visual evoked responses in cluster headache. Headache 1987, 27:446–451.

    Article  PubMed  CAS  Google Scholar 

  11. Bussone G, Sinatra MG, Boiardi A, et al.: Brainstem auditory evoked potential (BAEPs) in cluster headache (CH): new aspects for a central theory. Headache 1986, 26:67–69.

    Article  PubMed  CAS  Google Scholar 

  12. Firenze D, Del Gatto F, Mazzotta G, Gallai V: Somatosensoryevoked potential study in headache patients. Cephalalgia 1988, 8:157–162.

    Article  PubMed  CAS  Google Scholar 

  13. Frese A, Evers S, Buchheister A, et al.: Ipsilateral impairment of somatosensory trigeminal evoked potentials but not of blink reflex in cluster headache. In Cluster Headache and Related Conditions. Edited by Olesen J, Goadsby P. Oxford: Oxford University Press; 1999:144–149.

    Google Scholar 

  14. Vliet JA, Vein AA, Le Cessie S, et al.: Impairment of trigeminal sensory pathways in cluster headache. Cephalalgia 2003, 23:414–419.

    Article  PubMed  Google Scholar 

  15. Evers S, Bauer B, Suhr B, et al.: Cognitive processing in primary headache: a study on event-related potentials. Neurology 1997, 48:108–113.

    PubMed  CAS  Google Scholar 

  16. Kropp P, Gerber WD: Contingent negative variation during migraine attack and interval: evidence for normalization of slow potentials during the attack. Cephalalgia 1995, 15:123–128.

    Article  PubMed  CAS  Google Scholar 

  17. Evers S, Bauer B, Suhr B, et al.: Cognitive processing is involved in cluster headache, but not in chronic paroxysmal hemicrania. Neurology 1999, 53:357–363. The only systematic paper on cognitive-evoked potentials in cluster headache and chronic paroxysmal hemicrania.

    PubMed  CAS  Google Scholar 

  18. Kropp P, Gerber WD: Prediction of migraine attacks using a slow cortical potential, the contingent negative variation. Neurosci Lett 1998, 257:73–76.

    Article  PubMed  CAS  Google Scholar 

  19. Sinforiani E, Farina S, Mancuso A, et al.: Analysis of higher nervous functions in migraine and cluster headache. Funct Neurol 1987, 2:69–77.

    PubMed  CAS  Google Scholar 

  20. Meyer JS, Thornby J, Crawford K, Rauch GM: Reversible cognitive decline accompanies migraine and cluster headaches. Headache 2000, 40:638–646.

    Article  PubMed  CAS  Google Scholar 

  21. Meyer JS, Li YS, Thornby J: Validating mini-mental status, cognitive capacity screening and Hamilton depression scale utilizing subjects with vascular headaches. Int J Geriatr Psychiatry 2001, 16:430–435. The only paper on longitudinal cognitive measurements in patients with cluster headache showing a stable normal cognitive processing over time.

    Article  PubMed  CAS  Google Scholar 

  22. Levi R, Edman GV, Ekbom K, Waldenlind E: Episodic cluster headache I: personality and some neuropsychological characteristics in male patients. Headache 1992, 32:119–125.

    Article  PubMed  CAS  Google Scholar 

  23. Jorge RE, Leston JE, Arndt S, Robinson RG: Cluster headaches: association with anxiety disorders and memory deficits. Neurology 1999, 53:543–547.

    PubMed  CAS  Google Scholar 

  24. Blomkvist V, Hannerz J, Orth-Gomer K, Teorell T: Coping style and social support in women suffering from cluster headache or migraine. Psychother Psychosom 1997, 66:150–154.

    Article  PubMed  CAS  Google Scholar 

  25. Rogado AZ, Harrison RH, Graham JR: Personality profiles in cluster headache, migraine and normal controls. Arch Neurobiol 1974, 37:227–241.

    Google Scholar 

  26. Kudrow L, Sutkus BJ: MMPI pattern specificity in primary headache patients. Headache 1979, 19:18–24.

    Article  PubMed  CAS  Google Scholar 

  27. Merskey H, Brown J, Brown A, et al.: Psychological normality and abnormality in persistent headache patients. Pain 1985, 23:35–47.

    Article  PubMed  CAS  Google Scholar 

  28. Pfaffenrath V, Hummelsberger J, Pollmann W, et al.: MMPI personality profiles in patients with primary headache syndromes. Cephalalgia 1991, 11:263–268.

    Article  PubMed  CAS  Google Scholar 

  29. Mongini F, Ferla E, Maccagnani C: MMPI profiles in patients with headache or craniofacial pain: a comparative study. Cephalalgia 1992, 12:91–98.

    Article  PubMed  CAS  Google Scholar 

  30. Sjaastad O: Cluster Headache Syndrome. London: W.B. Saunders; 1992.

    Google Scholar 

  31. Bulpitt CJ, Fletcher AE: Cognitive function an angiotensinconverting enzyme inhibitors in comparison with other antihypertensive drugs. J Cardiovasc Pharmacol 1992, 19(suppl 6):S100-S104.

    PubMed  CAS  Google Scholar 

  32. Panagopoulos GR, Thomaides T, Tagaris G, Karageorgiou CL: Auditory event-related potentials in patients with epilepsy on sodium valproate monotherapy. Acta Neurol Scand 1997, 96:62–64.

    Article  PubMed  CAS  Google Scholar 

  33. Kaskey GB, Salzmann LF, Ciccone JR, Klorman R: Effects of lithium on evoked potentials and performance during sustained attention. Psychiatry Res 1980, 3:281–289.

    Article  PubMed  CAS  Google Scholar 

  34. Kocsis JH, Shaw ED, Stokes PE, et al.: Neuropsychologic effects of lithium discontinuation. J Clin Psychopharmacol 1993, 13:268–275.

    Article  PubMed  CAS  Google Scholar 

  35. Stoll AL, Locke CA, Vuckovic A, Mayer PV: Lithium-associated cognitive and functional deficits reduced by a switch to divalproex sodium: a case series. J Clin Psychiatry 1996, 57:356–359.

    PubMed  CAS  Google Scholar 

  36. Tandon OP, Kumar A, Dhar D, Battacharya A: Event-related evoked potential responses (P300) following epidural methylprednisolone therapy in chronic low back pain patients. Anaesthesia 1997, 52:1173–1176.

    Article  PubMed  CAS  Google Scholar 

  37. Born J, Seidel E, Pietrowsky R, Fehm HL: Brain-evoked responses, a bioassay for central actions of adrenocorticotropin (ACTH 1-39) and corticotrophin-releasing hormone (CRH) in humans. Horm Metab Res 1991, 23:126–130.

    Article  PubMed  CAS  Google Scholar 

  38. Evers S, Suhr B, Grotemeyer KH: Effects of sumatriptan on visually evoked event-related potentials. In Experimental Headache Models. Edited by Olesen J, Moskowitz M. Philadelphia: Lippincott Raven; 1995:289–292.

    Google Scholar 

  39. Evers S, Schmidt F, Bauer B, et al.: The impact of ergotamineinduced headache and ergotamine withdrawal on information processing. Psychopharmacology 1999, 142:61–67.

    Article  PubMed  CAS  Google Scholar 

  40. Bruce-Jones PN, Crome P, Kalra L: Indomethacin and cognitive function in healthy elderly volunteers. Br J Clin Pharmacol 1994, 38:45–51.

    PubMed  CAS  Google Scholar 

  41. Knight RT, Hillyard SA, Woods DL, Neville HJ: The effects of frontal cortex lesions on event-related potentials during auditory selective attention. Electroencephalogr Clin Neurophysiol 1981, 52:571–582.

    Article  PubMed  CAS  Google Scholar 

  42. Honda M, Suwazono S, Nagamine T, et al.: P300 abnormalities in patients with selective impairment of recent memory. J Neurol Sci 1996, 139:95–105.

    Article  PubMed  CAS  Google Scholar 

  43. Alexander JE, Bauer LO, Kuperman S, et al.: Hemispheric differences for P300 amplitude from an auditory oddball task. Int J Psychophysiol 1996, 21:189–196.

    Article  PubMed  CAS  Google Scholar 

  44. Martin-Loeches M, Barcelo F, Rubia FJ: Sources and topography of supramodal effects of spatial attention in ERP. Brain Topogr 1997, 10:9–22.

    Article  PubMed  CAS  Google Scholar 

  45. Evers S, Quibeldey F, Grotemeyer KH, et al.: Dynamic changes of cognitive habituation and serotonin metabolism during the migraine interval. Cephalalgia 1999, 19:485–491.

    Article  PubMed  CAS  Google Scholar 

  46. Schoenen J: Cortical electrophysiology in migraine and possible pathogenetic implications. Clin Neurosci 1998, 5:10–17.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Neurology, University of Münster, Albert-Schweitzer-Str. 33, 48129, Münster, Germany

    Stefan Evers MD, PhD

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  1. Stefan Evers MD, PhD
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Evers, S. Cognitive processing in cluster headache. Current Science Inc 9, 109–112 (2005). https://doi.org/10.1007/s11916-005-0047-y

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