Abstract
This article discusses topical intranasal medications in the treatment of cluster headache.
Similar content being viewed by others
References and Recommended Reading
The Sumatriptan Cluster Headache Study Group: Treatment of acute cluster headache with sumatriptan. N Engl J Med 1991, 325:322–326.
Gobel H, Lindner V, Heinze A, et al.: Acute therapy for cluster headache with sumatriptan: findings of a one-year long-term study. Neurology 1998, 51:908–911.
Hardebo JE, Dahlof C: Sumatriptan nasal spray (20 mg/dose) in the acute treatment of cluster headache. Cephalalgia 1998, 18:487–489.
Schuh-Hofer S, Reuter U, Kinze S, et al.: Treatment of acute cluster headache with 20 mg sumatriptan nasal spray: an open pilot study. J Neurol 2002, 249:94–99. This is a re-evaluation of the role of sumatriptan nasal spray in abortive treatment of cluster headache. Approximately 40% of patients showed continued benefit.
Manzoni GC: Cluster headache and lifestyle: remarks on a population of 374 male patients. Cephalalgia 1999, 19:88–94.
Shakra S, Becker WJ, Werner J, et al.: Zolmitriptan nasal spray is effective, fast-acting and well tolerated during both short and long-term treatment. Neurology 2002, 58(suppl 3):A414. New preliminary information about a rapidly acting triptan nasal spray recently introduced for migraine in Europe. It may be a promising agent in aborting cluster headache.
Andersson PG, Jespersen LT: Dihydroergotamine nasal spray in the treatment of attacks of cluster headache. Cephalalgia 1986, 6:51–54.
Sluder G: Role of the sphenopalatine (Meckel’s) ganglion in nasal headache. NY Med J 1908, 87:989–990.
Vail HH: Vidian neuralgia. Ann Otol Rhinol Laryngol 1932, 41:837–856.
Vail HH: Vidian neuralgia from disease of sphenoidal sinus; report of a case. Arch Surg 1929, 18:1247–1255.
Barré F: Cocaine as an abortive agent in cluster headache. Headache 1982, 22:69–73.
Costa A, Pucci E, Antonaci F, et al.: The effect of intranasal cocaine and lidocaine on nitroglycerin-induced attacks in cluster headache. Cephalalgia 2000, 20:85–91. This article compares intranasal cocaine and lidocaine. Cocaine remains therapeutically superior.
Kitrelle JP, Grouse DS, Seybold ME: Cluster headache: local anesthetic abortive agents. Arch Neurol 1985, 42:496–498.
Hardebo JE, Elner A: Nerves and vessels in the pterygopalatine fossa and symptoms of cluster headache. Headache 1987, 27:528–532. This is an excellent neuroanatomic review and tutorial on this important topic. Timeless.
Watson CPN, Evans, RJ: Chronic cluster headache: a review of 60 patients. Headache 1987, 27:158–165.
Robbins L: Intranasal lidocaine for cluster headache. Headache 1995, 35:83–84.
Kudrow L, Kudrow DB: Intranasal lidocaine. Headache 1995, 35:565–566.
Kudrow L, Kudrow DB, Sandweiss JH: Rapid and sustained relief of migraine attacks with intranasal lidocaine: preliminary findings. Headache 1995, 35:79–82.
Fusco BM, Giacovazzo M: Peppers and pain: the promise of capsaicin. Drugs 1997, 53:909–914.
Sicuteri F, Fusco BM, Marabini S, Fanciullacci M: Capsaicin as a potential medication for cluster headache. Med Sci Res 1988, 16:1079–1080.
Sicuteri F, Fusco BM, Marabini M, et al.: Beneficial effect of capsaicin application to the nasal mucosa in cluster headache. Clin J Pain 1989, 5:49–53.
Fusco BM, Fiore G, Gallo F, et al.: "Capsaicin-sensitive" sensory neurons in cluster headache: pathophysiological aspects and therapeutic indication. Headache 1994, 34:132–137.
Fusco BM, Geppetti P, Fanciullacci M, Sicuteri F: Local application of capsaicin for the treatment of cluster headache and trigeminal neuralgia. Cephalalgia 1991, 11(suppl 11):234–235.
Nicolodi M: Nostril capsaicin application as a model of trigeminal primary sensory neuronal activation. Cephalalgia 1994, 14:134–138.
Fusco BM, Marabini S, Maggi CA, et al.: Preventative effect of repeated nasal applications of capsaicin in cluster headache. Pain 1994, 59:321–325.
Marks DR, Rapoport A, Padla D: A double-blind, placebo-controlled trial of intranasal capsaicin for cluster headache. Cephalalgia 1993, 13:114–116.
Doggrell SA: Migraine and beyond: cardiovascular therapeutic potential for CGRP modulators. Expert Opin Invest Drugs 2001, 10:1131–1138.
Hua XY, Chen P, Hwang J, Yaksh TL: Antinociception induced by civamide, an orally active capsaicin analogue. Pain 1997, 71:313–322.
Diamond S, Freitag F, Phillips SB, et al.: Intranasal civamide for the acute treatment of migraine headache. Cephalalgia 2000, 20:597–602. This article introduces a new capsaicin analogue into development for the treatment of migraine. It would likely work better for prophylaxis of cluster headache.
Saper JR, Klapper J, Mathew NT, et al.: Intranasal civamide for the treatment of episodic cluster headaches. Arch Neurol 2002, 59:990–994. Civamide seems to work better for prophylaxis of cluster headache than for migraine abortion, but this small study does not show a robust effect.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Markley, H.G. Topical agents in the treatment of cluster headache. Current Science Inc 7, 139–143 (2003). https://doi.org/10.1007/s11916-003-0024-2
Issue Date:
DOI: https://doi.org/10.1007/s11916-003-0024-2