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The Effect of Type 2 Diabetes on Bone Biomechanics

  • Biomechanics (G Niebur and J Wallace, Section editors)
  • Published:
Current Osteoporosis Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

There is ample evidence that patients with type 2 diabetes (T2D) have increased risk of fracture even though they have normal or high bone mineral density. As a result, poor bone quality is suggested to contribute to skeletal fragility in this population. Thus, our goal was to conduct a comprehensive literature review to understand how bone quality components are altered in T2D and their effects on bone biomechanics and fracture risk.

Recent Findings

T2D does affect bone quality via alterations in bone microarchitecture, organic matrix, and cellular behavior. Further, studies indicate that bone biomechanical properties are generally deteriorated in T2D, but there are few reports in patients.

Summary

Additional work is needed to better understand molecular and cellular mechanisms that contribute to skeletal fragility in T2D. This knowledge can contribute to the development of improved diagnostic tools and drug targets to for improved quality of life for those with T2D.

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Acknowledgements

Dr. Karim was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number K01AR069685 and by the American Society for Bone and Mineral Research Rising Star Award. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.

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  1. Department of Bioengineering, University of Massachusetts Dartmouth, 285 Old Westport Road, Dartmouth, MA, 02747, USA

    Lamya Karim, Taraneh Rezaee & Rachana Vaidya

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Karim, L., Rezaee, T. & Vaidya, R. The Effect of Type 2 Diabetes on Bone Biomechanics. Curr Osteoporos Rep 17, 291–300 (2019). https://doi.org/10.1007/s11914-019-00526-w

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