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Crosstalk Between Sensory Nerves and Cancer in Bone

  • Cancer-induced Musculoskeletal Diseases (J Sterling and E Keller, Section Editors)
  • Published:
Current Osteoporosis Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Sensory nerves (SNs) richly innervate bone and are a component of bone microenvironment. Cancer metastasis in bone, which is under the control of the crosstalk with bone microenvironment, induces bone pain via excitation of SNs innervating bone. However, little is known whether excited SNs in turn affect bone metastasis.

Recent Findings

Cancer cells colonizing bone promote neo-neurogenesis of SNs and excite SNs via activation of the acid-sensing nociceptors by creating pathological acidosis in bone, evoking bone pain. Denervation of SNs or inhibition of SN excitation decreases bone pain and cancer progression and increases survival in preclinical models. Importantly, patients with cancers with increased SN innervation complain of cancer pain and show poor outcome.

Summary

SNs establish the crosstalk with cancer cells to contribute to bone pain and cancer progression in bone. Blockade of SN excitation may have not only analgesic effects on bone pain but also anti-cancer actions on bone metastases.

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Funding

The studies described in this review were partly supported by the Project Development Team within the ICTSI NIH/NCRR (#TR000006), start-up fund of Indiana University School of Medicine and Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (#17H04377).

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Authors and Affiliations

  1. Department of Biochemistry, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Toshiyuki Yoneda

  2. Department of Orthodontics and Dentofacial Orthodontics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 3-18-15, Kuramotocho, Tokushima, Tokushima, 770-8504, Japan

    Masahiro Hiasa

  3. Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, 2-5-1 Shikatacho, Kita-ku, Okayama, Okayama, 700-8525, Japan

    Tatsuo Okui

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  1. Toshiyuki Yoneda
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Correspondence to Toshiyuki Yoneda.

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This article is part of the Topical Collection on Cancer-induced Musculoskeletal Diseases

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Yoneda, T., Hiasa, M. & Okui, T. Crosstalk Between Sensory Nerves and Cancer in Bone. Curr Osteoporos Rep 16, 648–656 (2018). https://doi.org/10.1007/s11914-018-0489-x

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