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Bone Metabolism in Anorexia Nervosa

  • Epidemiology and Pathophysiology (PR Ebeling and EF Eriksen, Section Editors)
  • Published:
Current Osteoporosis Reports Aims and scope Submit manuscript

Abstract

Anorexia nervosa (AN), a psychiatric disorder predominantly affecting young women, is characterized by self-imposed, chronic nutritional deprivation and distorted body image. AN is associated with a number of medical comorbidities including low bone mass. The low bone mass in AN is due to an uncoupling of bone formation and bone resorption, which is the result of hormonal adaptations aimed at decreasing energy expenditure during periods of low energy intake. Importantly, the low bone mass in AN is associated with a significant risk of fractures and therefore treatments to prevent bone loss are critical. In this review, we discuss the hormonal determinants of low bone mass in AN and treatments that have been investigated in this population.

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Conflict of Interest

PK Fazeli has received research support from the NIH (K23 DK094820). A Klibanski has received research supplies from Ipsen (drug and placebo only for study) and Eli Lilly (drug and placebo only for study); and research support from the NIH (R24 DK092759).

Human and Animal Rights and Informed Consent

All studies by PK Fazeli and A Klibanski involving animal and/or human subjects were performed after approval by the appropriate institutional review boards. When required, written informed consent was obtained from all participants.

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  1. Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Bulfinch 457, Boston, MA, 02114, USA

    Pouneh K. Fazeli & Anne Klibanski

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  1. Pouneh K. Fazeli
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  2. Anne Klibanski
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Correspondence to Pouneh K. Fazeli.

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Fazeli, P.K., Klibanski, A. Bone Metabolism in Anorexia Nervosa. Curr Osteoporos Rep 12, 82–89 (2014). https://doi.org/10.1007/s11914-013-0186-8

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