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Role of Insulin-like Growth Factor-1 in the Regulation of Skeletal Growth

  • Skeletal Regulations (D Gaddy, Section Editor)
  • Published:
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Abstract

The importance of the insulin-like growth factor (IGF)-I axis in the regulation of bone size and bone mineral density, two important determinants of bone strength, has been well established from clinical studies involving patients with growth hormone deficiency and IGF-I gene disruption. Data from transgenic animal studies involving disruption and overexpression of components of the IGF-I axis also provide support for a key role for IGF-I in bone metabolism. IGF-I actions in bone are subject to regulation by systemic hormones, local growth factors, as well as mechanical stress. In this review we describe findings from various genetic mouse models that pertain to the role of endocrine and local sources of IGF-I in the regulation of skeletal growth.

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Acknowledgments

Financial support was received from funding agencies in the United States (NIH grant AR048139 and VA merit review grant).

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  1. Musculoskeletal Disease Center, Research Service (151), Jerry L Pettis VA Medical Center, 11201 Benton Street, Loma Linda, CA, 92357, USA

    Subburaman Mohan & Chandrasekhar Kesavan

  2. Department of Medicine, Biochemistry and Physiology, Loma Linda University, Loma Linda, CA, 92354, USA

    Subburaman Mohan & Chandrasekhar Kesavan

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Mohan, S., Kesavan, C. Role of Insulin-like Growth Factor-1 in the Regulation of Skeletal Growth. Curr Osteoporos Rep 10, 178–186 (2012). https://doi.org/10.1007/s11914-012-0100-9

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