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Nutrition and head and neck cancer

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Abstract

The role of nutrition in patients with head and neck cancer, specifically squamous cell carcinoma, is underappreciated. The composition of the diet can contribute to carcinogenesis, and specific nutrients may offer some protection in the presence of known carcinogens (ie, tobacco). Patients with head and neck cancer are frequently malnourished, which may have prognostic implications for the morbidity and outcome of therapies. Although the benefits of preoperative nutritional supplementation have been demonstrated only in severely malnourished patients, the use of immuneenhancing formulas may prove to be beneficial. Special consideration should be given to the nutritional needs and possible interactions of diet and therapy in patients receiving radiation and chemotherapy. Physicians should be cognizant of the widespread use of alternative diets and nutritional supplements that can be harmful and may interact with standard treatments. New knowledge regarding the role of nutrition in cancer offers hope for the nutritional chemoprevention of head and neck cancers.

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References and Recommended Reading

  1. Bumpous JM, Snyderman CH: Nutritional considerations in patients with cancer of the head and neck. In Cancer of the Head and Neck, edn 3. Edited by Myers EN, Suen JY. Philadelphia: WB Saunders; 1996:105–116.

    Google Scholar 

  2. Jacob RA: Passive smoking induces oxidant damage preventable by vitamin C: review. Nutr Rev 2000, 58:239–241.

    Article  PubMed  CAS  Google Scholar 

  3. Kesse E, Clavel-Chapelon F, Slimani N, van Liere M: Do eating habits differ according to alcohol consumption? Am J Clin Nutr 2001, 74:322–327.

    PubMed  CAS  Google Scholar 

  4. Inui A: Cancer anorexia-cachexia syndrome: current issues in research and management. CA Cancer J Clin 2002, 52:72–91. An informative review of the postulated mechanisms and promising therapies for the cancer anorexia-cachexia syndrome.

    PubMed  Google Scholar 

  5. Potter JD: Food, Nutrition and the Prevention of Cancer: A Global Perspective. Washington DC: American Institute for Cancer Research; 1997. Although this publication is now over 5 years old, it provides an excellent starting point for exploring the relationships between diet and cancer. The handy tables allow one to compare nutritional risk factors for different cancer sites and assess the strength of the data.

    Google Scholar 

  6. Petridou E, Zavras A, Lefatzis D, et al.: The role of diet and specific micronutrients in the etiology of oral carcinoma. Cancer 2002, 94:2981–2988.

    Article  PubMed  CAS  Google Scholar 

  7. De Stefani E, Oreggia F, Boffetta P, et al.: Tomatoes, tomato-rich foods, lycopene and cancer of the upper aerodigestive tract: a case-control in Uruguay. Oral Oncol 2000, 36:47–53.

    Article  PubMed  Google Scholar 

  8. Uzcudun AE, Retolaza IR, Fernandez PB, et al.: Nutrition and pharyngeal cancer: results from a case-control study in Spain. Head Neck 2002, 24:830–840.

    Article  PubMed  Google Scholar 

  9. Maillard V, Bougnoux P, Ferrari P, et al.: N-3 and N-6 fatty acids in breast tissue and relative risk of breast cancer in a case-control study in Tours, France. Int J Cancer 2002, 98:78–83.

    Article  PubMed  CAS  Google Scholar 

  10. Cowing BE, Saker KE: Polyunsaturated fatty acids and epidermal growth factor receptor/mitogen-activated protein kinase signaling in mammary cancer. J Nutr 2001, 131:1125–1128.

    PubMed  CAS  Google Scholar 

  11. Rose DP, Connolly JM: Regulation of tumor angiogenesis by dietary fatty acids and eicosanoids. Nutr Cancer 2000, 37:119–127. This review demonstrates how a particular group of nutrients (fatty acids) may affect multiple biologic processes that are involved in cancer progression and offers a dietary approach for treatment.

    Article  PubMed  CAS  Google Scholar 

  12. McCallum P: Patient-generated subjective global assessment. In The Clinical Guide to Oncology Nutrition. Edited by McCallum P, Polisena C. Rocklin, CA: American Dietetic Association; 2000:11–23.

    Google Scholar 

  13. Gerber MJ, Scali JD, Michaud A, et al.: Profiles of a healthful diet and its relationship to biomarkers in a population sample from Mediterranean southern France. J Am Diet Assoc 2000, 100:1164–1171.

    Article  PubMed  CAS  Google Scholar 

  14. Mekhail TM, Adelstein DJ, Rybicki LA, et al.: Enteral nutrition during the treatment of head and neck carcinoma: Is a percutaneous endoscopic gastrostomy tube preferable to a nasogastric tube? Cancer 2001, 91:1785–1790.

    Article  PubMed  CAS  Google Scholar 

  15. Bozzetti F, Braga M, Gianotti L, et al.: Postoperative enteral versus parenteral nutrition in malnourished patients with gastrointestinal cancer: a randomized multicenter trial. Lancet 2001, 358:1487–1492.

    Article  PubMed  CAS  Google Scholar 

  16. Braga M, Gianotti L, Gentilini O, et al.: Nutritional approach in malnourished surgical patients: a prospective randomized study. Crit Care Med 2001, 29:242–248.

    Article  PubMed  CAS  Google Scholar 

  17. Braunschweig CA: Creating a clinical nutrition registry: prospects, problems, and preliminary results. J Am Diet Assoc 1999, 99:467–470.

    Article  PubMed  CAS  Google Scholar 

  18. Schloerb PR: Immune-enhancing diets: products, components, and their rationales. J Parenter Enter Nutr 2001, 25:3–7. The major types of nutrients with immune-enhancing effects are reviewed, and a rationale for their use as nutritional supplements is provided.

    Google Scholar 

  19. Sax HC: Effect of immune enhancing formulas in general surgery patients. J Parenter Enter Nutr 2001, 25:19–23. The value of electively treating surgical patients with immuneenhancing formulas is discussed with a review of recent clinical trials.

    Article  Google Scholar 

  20. Ochoa JB, Strange J, Kearney P, et al.: Effects of L-arginine on the proliferation of T lymophocyte subpopulations. J Parenter Enter Nutr 2001, 25:23–29.

    Article  CAS  Google Scholar 

  21. Braga M: Nutritional approach in malnourished surgical patients: a prospective randomized study. Arch J 2002, 137:174–180.

    Google Scholar 

  22. Van Bokhorst-de van der Schueren MAE, Quak JJ, von Blomberg-van der Flier BME, et al.: Effect of perioperative nutrition, with and without arginine supplementation, on nutritional status, immune function, postoperative morbidity, and survival in severely malnourished head and neck cancer patients. Am J Clin Nutr 2001, 73:323–332.

    PubMed  Google Scholar 

  23. McCowen KC, Bistrian BR: Immunonutrition in critical illness. Nutr Clin Pract 2002, 17:265–266.

    PubMed  Google Scholar 

  24. Salem ML, Kishihara K, Koichiro A, et al.: N-3 polyunsaturated fatty acids accentuate B16 melanoma growth and metastasis through suppression of tumoricidal function of T cells and macrophages. Anticancer Res 2000, 20:3195–3204.

    PubMed  CAS  Google Scholar 

  25. Heyland DK, Novak F, Drover JW, et al.: Should immunonutrition become routine in critically Ill patients? JAMA 2001, 286:944–953.

    Article  PubMed  CAS  Google Scholar 

  26. American Society for Parenteral and Enteral Nutrition: Consensus recommendations from the U.S. Summit on Immune-Enhancing Enteral Therapy. J Parenter Enter Nutr 2001, 25:S61-S63. This consensus statement makes sense of the conflicting literature regarding the use of immune-enhancing formulas and provides recommendations for clinical practice based on the strength of the data and our current state of knowledge. Although the data are insufficient, practitioners believe that patients undergoing major head and neck surgery with preexisting malnutrition should benefit from immune-enhancing enteral therapy.

    Google Scholar 

  27. Conklin KA: Dietary antioxidants during cancer chemotherapy impact on chemotherapeutic effectiveness and development of side effects. Nutr Cancer 2000, 37:1–18. This review helps deal with some of the uncertainty regarding the possible adverse effects of nutritional supplements on the efficacy of chemotherapy. The use of antioxidants may ameliorate some of the side effects of chemotherapy and enhance patient response.

    Article  PubMed  CAS  Google Scholar 

  28. Labriola D, Livingston R: Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999, 13:1003–1011.

    PubMed  CAS  Google Scholar 

  29. American Dietetic Association: http://www.eatright.org

  30. Yam D, Peled A, Shinitzky M: Suppression of tumor growth and metastasis by dietary fish oil combined with vitamins E and C and cisplatin. Cancer Chemother Pharmacol 2001, 47:34–40.

    Article  PubMed  CAS  Google Scholar 

  31. Byers T, Nestle M, McTiernan A, et al., for the American Cancer Society 2001 Nutrition and Physical Activity Guidelines Advisory Committee: American Cancer Society guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin 2002, 52:92–119. Every physician needs to be familiar with current recommendations regarding nutrition and physical activity for cancer prevention. This review summarizes the ACS guidelines with recommendations for specific tumor sites. A valuable addition for advising patients is the section entitled „Common Questions About Diet and Cancer.”

    Article  PubMed  Google Scholar 

  32. Simopoulos AP: The Mediterranean diets: What is so special about the diet of Greece? The scientific evidence. J Nutr 2001, 131:3065–3073. The benefits and mechanisms of action of the Mediterranean diets are explored here. This article demonstrates the importance of a holistic dietary approach for the prevention of cancer.

    Google Scholar 

  33. Greenwald P: Cancer chemoprevention. BMJ 2002, 324:714–718.

    Article  PubMed  CAS  Google Scholar 

  34. Heinonen OP, Huttunen JK, Albanes D: The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994, 330:1029–1035.

    Article  Google Scholar 

  35. Omenn GS, Goodman GE, Thornquist MD, et al.: Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996, 334:1150–1155.

    Article  PubMed  CAS  Google Scholar 

  36. Brown J, Byers T, Thompson K, et al.: Nutrition during and after cancer treatment: a guide for informed choices by cancer survivors. CA Cancer J Clin 2001, 51:153–187.

    PubMed  CAS  Google Scholar 

  37. Go VL, Wong DA, Butrum R: Diet, nutrition and cancer prevention: Where are we going from here? J Nutr 2001, 131:3121–3126.

    Google Scholar 

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Snyderman, C.H. Nutrition and head and neck cancer. Curr Oncol Rep 5, 158–163 (2003). https://doi.org/10.1007/s11912-003-0104-9

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  • DOI: https://doi.org/10.1007/s11912-003-0104-9

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