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New Daily Persistent Headache and Potential New Therapeutic Agents

  • Headache (R Halker, Section Editor)
  • Published:
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Abstract

New daily persistent headache is a form of a chronic daily headache with a unique temporal profile. Patients can recall the exact day when their headache started. It can be one of the most refractory types of headache to treat. Recent publications have highlighted different subtypes and heterogeneity in presentation. Referring to it as a syndrome versus a distinct disorder has also been suggested. Several different classes of medications have been used for the treatment, with mixed results. The underlying pathophysiology of new daily persistent headache is unclear, but tumor necrosis factor may play a role. The clinical features, differential diagnosis and potential new therapeutic agents will be discussed.

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References

Papers of particular interest, all but one that is published recently, have been highlighted as: • Of Importance •• Of major importance

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Conflict of Interest

Shivang G. Joshi, Paul G. Mathew, and Herbert G. Markley declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Department of Neurology, New England Regional Headache Center, University of Massachusetts Medical School, 85 Prescott Street Suite 101, Worcester, MA, 01605, USA

    Shivang G. Joshi & Herbert G. Markley

  2. Department of Neurology, John R. Graham Headache Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02130, USA

    Paul G. Mathew

  3. Division of Neurology, Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, 02139, USA

    Paul G. Mathew

Authors
  1. Shivang G. Joshi
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  2. Paul G. Mathew
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  3. Herbert G. Markley
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Correspondence to Shivang G. Joshi.

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This article is part of the Topical Collection on Headache

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Joshi, S.G., Mathew, P.G. & Markley, H.G. New Daily Persistent Headache and Potential New Therapeutic Agents. Curr Neurol Neurosci Rep 14, 425 (2014). https://doi.org/10.1007/s11910-013-0425-5

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  • DOI: https://doi.org/10.1007/s11910-013-0425-5

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