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Misdiagnosis of Multiple Sclerosis: Frequency, Causes, Effects, and Prevention

  • Demyelinating Disorders (DN Bourdette and V Yadav, Section Editors)
  • Published:
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Abstract

A diagnosis of multiple sclerosis is heavily influenced by clinical judgment. Misdiagnosis of multiple sclerosis is common and has important consequences for patients and the cost of healthcare. Although rigorous data about the frequency and causes of misdiagnosis are lacking, misinterpretation and misapplication of clinical and radiographic diagnostic criteria and terminology are likely important factors. Appropriate and stringent application of diagnostic criteria and continued vigilance for “red flags” suggesting alternative diagnoses are strategies critical for prevention of misdiagnosis.

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Conflict of Interest

Andrew J. Solomon declares that he has no conflict of interest. Brian G. Weinshenker has been a consultant for GSK Pharmaceuticals, Chord Pharmaceuticals, Ono Pharmaceuticals, Guthy Jackson Charitable Foundation; he has received grant support from Guthy Jackson Charitable Foundation; he has received patents (planned, pending, or issued) for AQP4 antibodies for diagnosis of NMO; and he has received royalties from RSR Ltd. for AQP4 antibodies for diagnosis of NMO.

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  1. Department of Neurological Sciences, University of Vermont College of Medicine, 1 South Prospect St, Burlington, VT, 05401, USA

    Andrew J. Solomon

  2. Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Brian G. Weinshenker

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  1. Andrew J. Solomon
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Correspondence to Andrew J. Solomon.

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This article is part of the Topical Collection on Demyelinating Disorders

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Solomon, A.J., Weinshenker, B.G. Misdiagnosis of Multiple Sclerosis: Frequency, Causes, Effects, and Prevention. Curr Neurol Neurosci Rep 13, 403 (2013). https://doi.org/10.1007/s11910-013-0403-y

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