Skip to main content

Advertisement

Log in

Use of Telemedicine and Other Strategies to Increase the Number of Patients That May Be Treated with Intravenous Thrombolysis

  • Stroke (HP Adams Jr, Section Editor)
  • Published:
Current Neurology and Neuroscience Reports Aims and scope Submit manuscript

Abstract

Stroke is the fourth leading killer in the United States and a leading cause of adult long-term disability. The American Heart Association estimates that only 3% to 5% of patients with acute ischemic stroke are treated with intravenous thrombolysis. A way to improve the rates of treatment with thrombolysis in patients with acute ischemic stroke is the creation of telemedicine stroke networks. Data from many studies support the safety of expanding intravenous tissue plasminogen activator use with the help of telemedicine. In this article we discuss the current evidence for the use of telemedicine within stroke systems of care, the importance of coordinating care within the transferring facilities in the telestroke networks, telestroke economics and applicability, and how to potentially use the telestroke systems to increase recruitment of patients into acute stroke thrombolysis trials.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Lloyd-Jones D, Adams RJ, Brown TM, et al. Heart disease and stroke statistics–2010 update: a report from the American Heart Association. Circulation. 2010;121:e46–e215.

    Article  PubMed  Google Scholar 

  2. The national institute of neurological disorders and stroke rt-pa stroke study group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581–7.

    Article  Google Scholar 

  3. Bluhmki E, Chamorro A, Davalos A, et al. Stroke treatment with alteplase given 3.0–4.5 h after onset of acute ischaemic stroke (ECASS III): additional outcomes and subgroup analysis of a randomised controlled trial. Lancet Neurol. 2009;8:1095–102.

    Article  PubMed  CAS  Google Scholar 

  4. Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359:1317–29.

    Article  PubMed  CAS  Google Scholar 

  5. Kwan J, Hand P, Sandercock P. A systematic review of barriers to delivery of thrombolysis for acute stroke. Age Ageing. 2004;33:116–21.

    Article  PubMed  Google Scholar 

  6. Ehlers L, Jensen LG, Bech MA, et al. Organisational barriers to thrombolysis treatment of acute ischaemic stroke. Curr Med Res Opin. 2007;23:2833–9.

    Article  PubMed  Google Scholar 

  7. Adeoye O, Hornung R, Khatri P, et al. Recombinant tissue-type plasminogen activator use for ischemic stroke in the united states: a doubling of treatment rates over the course of 5 years. Stroke. 2011;42:1952–5.

    Article  PubMed  CAS  Google Scholar 

  8. Engelter ST, Gostynski M, Papa S, et al. Barriers to stroke thrombolysis in a geographically defined population. Cerebrovasc Dis. 2007;23:211–5.

    Article  PubMed  CAS  Google Scholar 

  9. •• Schwamm LH, Holloway RG, Amarenco P, et al. A review of the evidence for the use of telemedicine within stroke systems of care: a scientific statement from the american heart association/american stroke association. Stroke. 2009;40:2616–34. A task force of physicians reviewed the literature thoroughly to assess the scientific basis for the use of telemedicine within stroke systems of care. This article provides a comprehensive and evidence-based review of the scientific data evaluating the use of telemedicine for stroke care delivery and provided consensus recommendations based on the available evidence.

    Article  PubMed  Google Scholar 

  10. • Schwamm LH, Audebert HJ, Amarenco P, et al. Recommendations for the implementation of telemedicine within stroke systems of care: a policy statement from the american heart association. Stroke. 2009;40:2635–60. This report was commissioned by the American Heart Association to address how telemedicine might help address current barriers to improved stroke care delivery in the United States within the framework of the stroke systems of care model.

    Article  PubMed  Google Scholar 

  11. Pervez MA, Silva G, Masrur S, et al. Remote supervision of iv-tpa for acute ischemic stroke by telemedicine or telephone before transfer to a regional stroke center is feasible and safe. Stroke. 2010;41:e18–24.

    Article  PubMed  Google Scholar 

  12. Meyer BC, Raman R, Ernstrom K, et al. Assessment of long-term outcomes for the stroke doc telemedicine trial. J Stroke Cerebrovasc Dis. In Press, Available online 19 September 2010.

  13. Khan K, Shuaib A, Whittaker T, et al. Telestroke in northern Alberta: a two year experience with remote hospitals. Can J Neurol Sci. 2010;37:808–13.

    PubMed  Google Scholar 

  14. Donnan GA, Baron JC, Ma H, et al. Penumbral selection of patients for trials of acute stroke therapy. Lancet Neurol. 2009;8:261–9.

    Article  PubMed  CAS  Google Scholar 

  15. Reza Noorian A, Nogueira R, Gupta R. Neuroprotection in acute ischemic stroke. J Neurosurg Sci. 2011;55:127–38.

    PubMed  CAS  Google Scholar 

  16. Sahota P, Savitz SI. Investigational therapies for ischemic stroke: neuroprotection and neurorecovery. Neurotherapeutics. 2011;8:434–51.

    Article  PubMed  CAS  Google Scholar 

  17. Liebeskind DS. Reversing stroke in the 2010s: lessons from desmoteplase in acute ischemic stroke-2 (DIAS-2). Stroke. 2009;40:3156–8.

    Article  PubMed  Google Scholar 

  18. Hacke W, Furlan AJ, Al-Rawi Y, et al. Intravenous desmoteplase in patients with acute ischaemic stroke selected by mri perfusion-diffusion weighted imaging or perfusion ct (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol. 2009;8:141–50.

    Article  PubMed  CAS  Google Scholar 

  19. Grigsby RK. Telemedicine. JAMA. 1995;274:461–2.

    Article  PubMed  CAS  Google Scholar 

  20. Grigsby J, Sanders JH. Telemedicine: where it is and where it’s going. Ann Intern Med. 1998;129:123–7.

    PubMed  CAS  Google Scholar 

  21. Levine SR, Gorman M. “Telestroke”: the application of telemedicine for stroke. Stroke. 1999;30:464–9.

    Article  PubMed  CAS  Google Scholar 

  22. Ekeland AG, Bowes A, Flottorp S. Effectiveness of telemedicine: a systematic review of reviews. Int J Med Inform. 2010;79:736–71.

    Article  PubMed  Google Scholar 

  23. Garg V, Brewer J. Telemedicine security: a systematic review. J Diabetes Sci Technol. 2011;5:768–77.

    PubMed  Google Scholar 

  24. Switzer JA, Levine SR, Hess DC. Telestroke 10 years later-‘telestroke 2.0’. Cerebrovasc Dis. 2009;28:323–30.

    Article  PubMed  Google Scholar 

  25. Birns J, Bhalla A, Rudd A. Telestroke: a concept in practice. Age Ageing. 2010;39:666–7.

    Article  PubMed  Google Scholar 

  26. Emsley H, Blacker K, Davies P, et al. Telestroke. When location, location, location doesn’t matter. Health Serv J. 2010;120:24–5.

    PubMed  Google Scholar 

  27. Johansson T, Wild C. Telemedicine in acute stroke management: systematic review. Int J Technol Assess Health Care. 2010;26:149–55.

    Article  PubMed  Google Scholar 

  28. Stradling DA. Telestroke: state of the science and steps for implementation. Crit Care Nurs Clin North Am. 2009;21:541–8.

    Article  PubMed  Google Scholar 

  29. Demaerschalk BM. Telestrokologists: treating stroke patients here, there, and everywhere with telemedicine. Semin Neurol. 2010;30:477–91.

    Article  PubMed  Google Scholar 

  30. Silver FL. Telestroke: the management of acute ischemic stroke from a distance. Can J Neurol Sci. 2010;37:717–8.

    PubMed  Google Scholar 

  31. Saler M, Switzer JA, Hess DC. Use of telemedicine and helicopter transport to improve stroke care in remote locations. Current Treatment Options in Cardiovascular Medicine. 2011;13:215–24.

    Article  PubMed  Google Scholar 

  32. The ninds t-pa stroke study group. Intracerebral hemorrhage after intravenous t-pa therapy for ischemic stroke. Stroke. 1997;28:2109–18.

    Article  Google Scholar 

  33. Hill MD, Lye T, Moss H, et al. Hemi-orolingual angioedema and ace inhibition after alteplase treatment of stroke. Neurology. 2003;60:1525–7.

    PubMed  CAS  Google Scholar 

  34. Gimenez-Munoz A, Capablo-Liesa JL, Torne-Hernandez L, et al. Orolingual angioedema secondary to alteplase treatment in cases of stroke. Rev Neurol. 2008;46:382.

    PubMed  CAS  Google Scholar 

  35. Adams Jr HP, del Zoppo G, Alberts MJ, et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the american heart association/american stroke association stroke council, clinical cardiology council, cardiovascular radiology and intervention council, and the atherosclerotic peripheral vascular disease and quality of care outcomes in research interdisciplinary working groups. Circulation. 2007;115:e478–534.

    Article  PubMed  Google Scholar 

  36. Stewart SF, Switzer JA. Perspectives on telemedicine to improve stroke treatment. Drugs Today (Barc). 2011;47:157–67.

    CAS  Google Scholar 

  37. Gunzel F, Theiss S, Knuppel P, et al. Telemedicine in acute stroke care–a health economics view. Dtsch Med Wochenschr. 2010;135:84–90.

    Article  PubMed  CAS  Google Scholar 

  38. Dharmasaroja PA, Muengtaweepongsa S, Kommarkg U. Implementation of telemedicine and stroke network in thrombolytic administration: comparison between walk-in and referred patients. Neurocrit Care. 2010;13:62–6.

    Article  PubMed  Google Scholar 

  39. • de Bustos EM, Vuillier F, Chavot D, et al. Telemedicine in stroke: organizing a network–rationale and baseline principles. Cerebrovasc Dis. 2009;27(Suppl 4):1–8. This article focuses on the development and implementation of a telemedicine network for stroke. It discusses the long-term actions that are important to assure the sustainability of telestroke such as medicolegal, economic, and market issues.

    Article  PubMed  Google Scholar 

  40. de Bustos EM, Moulin T, Audebert HJ. Barriers, legal issues, limitations and ongoing questions in telemedicine applied to stroke. Cerebrovasc Dis. 2009;27 Suppl 4:36–9.

    Article  PubMed  Google Scholar 

  41. Cho S, Khasanshina EV, Mathiassen L, et al. An analysis of business issues in a telestroke project. J Telemed Telecare. 2007;13:257–62.

    Article  PubMed  Google Scholar 

  42. Audebert H. Telestroke: effective networking. Lancet Neurol. 2006;5:279–82.

    Article  PubMed  Google Scholar 

  43. Switzer JA, Hall CE, Close B, et al. A telestroke network enhances recruitment into acute stroke clinical trials. Stroke. 2010;41:566–9.

    Article  PubMed  Google Scholar 

  44. Leira EC, Ahmed A, Lamb DL, et al. Extending acute trials to remote populations: a pilot study during interhospital helicopter transfer. Stroke. 2009;40:895–901.

    Article  PubMed  Google Scholar 

  45. Saver JL, Kidwell C, Eckstein M, et al. Physician-investigator phone elicitation of consent in the field: a novel method to obtain explicit informed consent for prehospital clinical research. Prehosp Emerg Care. 2006;10:182–5.

    Article  PubMed  Google Scholar 

Download references

Disclosure

Conflicts of interest: G.S. Silva: none; L.H. Schwamm: his hospital provides telehealth services for a fee, including telestroke services.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gisele Sampaio Silva.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Silva, G.S., Schwamm, L.H. Use of Telemedicine and Other Strategies to Increase the Number of Patients That May Be Treated with Intravenous Thrombolysis. Curr Neurol Neurosci Rep 12, 10–16 (2012). https://doi.org/10.1007/s11910-011-0235-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11910-011-0235-6

Keywords

Navigation