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Hepatitis E in Transplantation

  • Transplant and Oncology (M Ison, N Theodoropoulos and S Pegram, Section Editors)
  • Published:
Current Infectious Disease Reports Aims and scope Submit manuscript

Abstract

Hepatitis E virus (HEV) has a worldwide distribution and is known to cause acute and fulminant hepatitis. However, over the last few years, it has been shown to also cause chronic hepatitis and cirrhosis in immunosuppressed patients, especially solid-organ-transplant patients. In immunocompetent and immunosuppressed patients, HEV is also associated with extra-hepatic manifestations, such as neurological symptoms and kidney injury. Unfortunately, a diagnostic assay for HEV infection is still not available in all countries. Reduction of immunosuppression is the first-line therapeutic option for organ-transplant patients with chronic hepatitis. In addition, ribavirin is highly efficient at treating chronic HEV infection. In this comprehensive review, we summarize the current knowledge regarding HEV diagnosis, its natural history, clinical manifestations, and treatments in patients with a solid-organ transplant.

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Authors and Affiliations

  1. Department of Nephrology and Organ Transplantation, CHU Rangueil, TSA 50032, 31059, Toulouse Cedex 9, France

    Olivier Marion & Nassim Kamar

  2. INSERM U1043, IFR–BMT, CHU Purpan, Toulouse, France

    Florence Abravanel, Sebastien Lhomme, Jacques Izopet & Nassim Kamar

  3. Université Paul Sabatier, Toulouse, France

    Florence Abravanel, Sebastien Lhomme, Jacques Izopet & Nassim Kamar

  4. Laboratory of Virology, CHU Purpan, Toulouse, France

    Florence Abravanel, Sebastien Lhomme & Jacques Izopet

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  1. Olivier Marion
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  2. Florence Abravanel
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  3. Sebastien Lhomme
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  4. Jacques Izopet
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  5. Nassim Kamar
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Correspondence to Nassim Kamar.

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Drs Marion, Abravanel, Lhomme, Izopet, and Kamar declare no conflicts of interests.

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This article is part of the Topical Collection on Transplant and Oncology

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Marion, O., Abravanel, F., Lhomme, S. et al. Hepatitis E in Transplantation. Curr Infect Dis Rep 18, 8 (2016). https://doi.org/10.1007/s11908-016-0515-z

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