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Adenovirus: Current Epidemiology and Emerging Approaches to Prevention and Treatment

  • Transplant and Oncology (M Ison, Section Editor)
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Abstract

Infections caused by adenoviruses are associated with significant morbidity and mortality in both hematopoietic stem cell and solid organ transplant recipients. The risk seems to be highest in allogeneic hematopoietic stem cell transplant recipients as well as heart, lung and small-bowel transplant recipients. Management of these infections may be difficult and includes reduction of immunosuppression whenever possible combined sometimes with antiviral therapy (mainly cidofovir). The currently available antiviral therapy is limited by the need for intravenous administration, potentially significant renal and hematologic toxicities. New emerging therapies such as brincidofovir and transfusion of adenovirus-specific T-lymphocytes may increase the available armamentarium for these potentially life-threatening infections.

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References

Papers of particular interest, published recently, have been highlighted as: •• Of major importance

  1. Ruuskanen O, Meurman O, Akusjärvi G. Adenoviruses. In: Richman DD, Whitley RJ, Hayden FG, editors. Clinical virology. Washington, DC: ASM Press; 2002. p. 515–35.

    Google Scholar 

  2. Echavarria M. Adenoviruses in immunocompromised hosts. Clin Microbiol Rev. 2008;21(4):704–15.

    Article  PubMed Central  PubMed  Google Scholar 

  3. Hoffman JA. Adenovirus infections in solid organ transplant recipients. Curr Opin Organ Transplant. 2009;14(6):625–33.

    Article  PubMed  Google Scholar 

  4. Florescu DF, Hoffman JA. Adenovirus in solid organ transplantation. Am J Transplant. 2013;13 Suppl 4:206–11.

    Article  CAS  PubMed  Google Scholar 

  5. Garnett CT, Erdman D, Xu W, Gooding LR. Prevalence and quantitation of species C adenovirus DNA in human mucosal lymphocytes. J Virol. 2002;76(21):10608–16.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Matthes-Martin S, Feuchtinger T, Shaw PJ, et al. European guidelines for diagnosis and treatment of adenovirus infection in leukemia and stem cell transplantation: summary of ECIL-4 (2011). Transpl Infect Dis. 2012;14(6):555–63.

    Article  CAS  PubMed  Google Scholar 

  7. Mori Y, Miyamoto T, Kamezaki K, et al. Low incidence of adenovirus hemorrhagic cystitis following autologous hematopoietic stem cell transplantation in the rituximab era. Am J Hematol. 2012;87(8):828–30.

    Article  CAS  PubMed  Google Scholar 

  8. Abinun M, Flood TJ, Cant AJ, et al. Autologous T cell depleted haematopoietic stem cell transplantation in children with severe juvenile idiopathic arthritis in the UK (2000-2007). Mol Immunol. 2009;47(1):46–51.

    Article  CAS  PubMed  Google Scholar 

  9. Bruno B, Gooley T, Hackman RC, Davis C, Corey L, Boeckh M. Adenovirus infection in hematopoietic stem cell transplantation: effect of ganciclovir and impact on survival. Biol Blood Marrow Transplant. 2003;9(5):341–52.

    Article  PubMed  Google Scholar 

  10. Kohno K, Nagafuji K, Tsukamoto H, et al. Infectious complications in patients receiving autologous CD34-selected hematopoietic stem cell transplantation for severe autoimmune diseases. Transpl Infect Dis. 2009;11(4):318–23.

    Article  CAS  PubMed  Google Scholar 

  11. Blanke C, Clark C, Broun ER, et al. Evolving pathogens in allogeneic bone marrow transplantation: increased fatal adenoviral infections. Am J Med. 1995;99(3):326–8.

    Article  CAS  PubMed  Google Scholar 

  12. Bordigoni P, Carret AS, Venard V, Witz F, Le Faou A. Treatment of adenovirus infections in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis. 2001;32(9):1290–7.

    Article  CAS  PubMed  Google Scholar 

  13. Echavarria M, Forman M, van Tol MJ, Vossen JM, Charache P, Kroes AC. Prediction of severe disseminated adenovirus infection by serum PCR. Lancet. 2001;358(9279):384–5.

    Article  CAS  PubMed  Google Scholar 

  14. Flomenberg P, Babbitt J, Drobyski WR, et al. Increasing incidence of adenovirus disease in bone marrow transplant recipients. J Infect Dis. 1994;169(4):775–81.

    Article  CAS  PubMed  Google Scholar 

  15. Hale GA, Heslop HE, Krance RA, et al. Adenovirus infection after pediatric bone marrow transplantation. Bone Marrow Transplant. 1999;23(3):277–82.

    Article  CAS  PubMed  Google Scholar 

  16. Hoffman JA, Shah AJ, Ross LA, Kapoor N. Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2001;7(7):388–94.

    Article  CAS  PubMed  Google Scholar 

  17. Howard DS, Phillips IG, Reece DE, et al. Adenovirus infections in hematopoietic stem cell transplant recipients. Clin Infect Dis. 1999;29(6):1494–501.

    Article  CAS  PubMed  Google Scholar 

  18. Kalpoe JS, van der Heiden PL, Barge RM, et al. Assessment of disseminated adenovirus infections using quantitative plasma PCR in adult allogeneic stem cell transplant recipients receiving reduced intensity or myeloablative conditioning. Eur J Haematol. 2007;78(4):314–21.

    Article  CAS  PubMed  Google Scholar 

  19. Kampmann B, Cubitt D, Walls T, et al. Improved outcome for children with disseminated adenoviral infection following allogeneic stem cell transplantation. Br J Haematol. 2005;130(4):595–603.

    Article  CAS  PubMed  Google Scholar 

  20. Kroes AC, de Klerk EP, Lankester AC, et al. Sequential emergence of multiple adenovirus serotypes after pediatric stem cell transplantation. J Clin Virol. 2007;38(4):341–7.

    Article  CAS  PubMed  Google Scholar 

  21. La Rosa AM, Champlin RE, Mirza N, et al. Adenovirus infections in adult recipients of blood and marrow transplants. Clin Infect Dis. 2001;32(6):871–6.

    Article  PubMed  Google Scholar 

  22. Leruez-Ville M, Minard V, Lacaille F, et al. Real-time blood plasma polymerase chain reaction for management of disseminated adenovirus infection. Clin Infect Dis. 2004;38(1):45–52.

    Article  CAS  PubMed  Google Scholar 

  23. Ljungman P, Gleaves CA, Meyers JD. Respiratory virus infection in immunocompromised patients. Bone Marrow Transplant. 1989;4(1):35–40.

    CAS  PubMed  Google Scholar 

  24. Shields AF, Hackman RC, Fife KH, Corey L, Meyers JD. Adenovirus infections in patients undergoing bone-marrow transplantation. New Engl J Med. 1985;312(9):529–33.

    Article  CAS  PubMed  Google Scholar 

  25. van Tol MJ, Claas EC, Heemskerk B, et al. Adenovirus infection in children after allogeneic stem cell transplantation: diagnosis, treatment and immunity. Bone Marrow Transplant. 2005;35 Suppl 1:S73–6.

    PubMed  Google Scholar 

  26. Venard V, Carret A, Corsaro D, Bordigoni P, Le Faou A. Genotyping of adenoviruses isolated in an outbreak in a bone marrow transplant unit shows that diverse strains are involved. J Hosp Infect. 2000;44(1):71–4.

    Article  CAS  PubMed  Google Scholar 

  27. Wasserman R, August CS, Plotkin SA. Viral infections in pediatric bone marrow transplant patients. Pediatr Infect Dis J. 1988;7(2):109–15.

    Article  CAS  PubMed  Google Scholar 

  28. Yusuf U, Hale GA, Carr J, et al. Cidofovir for the treatment of adenoviral infection in pediatric hematopoietic stem cell transplant patients. Transplantation. 2006;81(10):1398–404.

    Article  CAS  PubMed  Google Scholar 

  29. Baldwin A, Kingman H, Darville M, et al. Outcome and clinical course of 100 patients with adenovirus infection following bone marrow transplantation. Bone Marrow Transplant. 2000;26(12):1333–8.

    Article  CAS  PubMed  Google Scholar 

  30. Chakrabarti S, Mautner V, Osman H, et al. Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery. Blood. 2002;100(5):1619–27.

    Article  CAS  PubMed  Google Scholar 

  31. Erard V, Huang ML, Ferrenberg J, et al. Quantitative real-time polymerase chain reaction for detection of adenovirus after T cell-replete hematopoietic cell transplantation: viral load as a marker for invasive disease. Clin Infect Dis. 2007;45(8):958–65.

    Article  CAS  PubMed  Google Scholar 

  32. Ganzenmueller T, Buchholz S, Harste G, Dammann E, Trenschel R, Heim A. High lethality of human adenovirus disease in adult allogeneic stem cell transplant recipients with high adenoviral blood load. J Clin Virol. 2011;52(1):55–9.

    Article  PubMed  Google Scholar 

  33. Gustafson I, Lindblom A, Yun Z, et al. Quantification of adenovirus DNA in unrelated donor hematopoietic stem cell transplant recipients. J Clin Virol. 2008;43(1):79–85.

    Article  CAS  PubMed  Google Scholar 

  34. Lion T, Baumgartinger R, Watzinger F, et al. Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease. Blood. 2003;102(3):1114–20.

    Article  CAS  PubMed  Google Scholar 

  35. Lion T, Kosulin K, Landlinger C, et al. Monitoring of adenovirus load in stool by real-time PCR permits early detection of impending invasive infection in patients after allogeneic stem cell transplantation. Leukemia. 2010;24(4):706–14.

    Article  CAS  PubMed  Google Scholar 

  36. Schilham MW, Claas EC, van Zaane W, et al. High levels of adenovirus DNA in serum correlate with fatal outcome of adenovirus infection in children after allogeneic stem-cell transplantation. Clin Infect Dis. 2002;35(5):526–32.

    Article  PubMed  Google Scholar 

  37. Avivi I, Chakrabarti S, Milligan DW, et al. Incidence and outcome of adenovirus disease in transplant recipients after reduced-intensity conditioning with alemtuzumab. Biol Blood Marrow Transplant. 2004;10(3):186–94.

    Article  PubMed  Google Scholar 

  38. Myers GD, Krance RA, Weiss H, et al. Adenovirus infection rates in pediatric recipients of alternate donor allogeneic bone marrow transplants receiving either antithymocyte globulin (ATG) or alemtuzumab (Campath). Bone Marrow Transplant. 2005;36(11):1001–8.

    Article  CAS  PubMed  Google Scholar 

  39. McGrath D, Falagas ME, Freeman R, et al. Adenovirus infection in adult orthotopic liver transplant recipients: incidence and clinical significance. J Infect Dis. 1998;177(2):459–62.

    Article  CAS  PubMed  Google Scholar 

  40. Michaels MG, Green M, Wald ER, Starzl TE. Adenovirus infection in pediatric liver transplant recipients. J Infect Dis. 1992;165(1):170–4.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  41. de Mezerville MH, Tellier R, Richardson S, Hebert D, Doyle J, Allen U. Adenoviral infections in pediatric transplant recipients: a hospital-based study. Pediatr Infect Dis J. 2006;25(9):815–8.

    Article  PubMed  Google Scholar 

  42. Bridges ND, Spray TL, Collins MH, Bowles NE, Towbin JA. Adenovirus infection in the lung results in graft failure after lung transplantation. J Thorac Cardiovasc Surg. 1998;116(4):617–23.

    Article  CAS  PubMed  Google Scholar 

  43. Doan ML, Mallory GB, Kaplan SL, et al. Treatment of adenovirus pneumonia with cidofovir in pediatric lung transplant recipients. J Heart Lung Transplant. 2007;26(9):883–9.

    Article  PubMed  Google Scholar 

  44. Liu M, Mallory GB, Schecter MG, et al. Long-term impact of respiratory viral infection after pediatric lung transplantation. Pediatr Transplant. 2010;14(3):431–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  45. Liu M, Worley S, Arrigain S, et al. Respiratory viral infections within one year after pediatric lung transplant. Transplant Infect Dis. 2009;11(4):304–12.

    Article  CAS  Google Scholar 

  46. Ohori NP, Michaels MG, Jaffe R, Williams P, Yousem SA. Adenovirus pneumonia in lung transplant recipients. Hum Pathol. 1995;26(10):1073–9.

    Article  CAS  PubMed  Google Scholar 

  47. Humar A, Doucette K, Kumar D, et al. Assessment of adenovirus infection in adult lung transplant recipients using molecular surveillance. J Heart Lung Transplant. 2006;25(12):1441–6.

    Article  PubMed  Google Scholar 

  48. Florescu DF, Kwon JY, Dumitru I. Adenovirus infections in heart transplantation. Cardiol Rev. 2013;21(4):203–6.

    Article  PubMed  Google Scholar 

  49. Watcharananan SP, Avery R, Ingsathit A, et al. Adenovirus disease after kidney transplantation: course of infection and outcome in relation to blood viral load and immune recovery. Am J Transplant. 2011;11(6):1308–14.

    Article  CAS  PubMed  Google Scholar 

  50. Engelmann G, Heim A, Greil J, et al. Adenovirus infection and treatment with cidofovir in children after liver transplantation. Pediatr Transplant. 2009;13(4):421–8.

    Article  CAS  PubMed  Google Scholar 

  51. Koneru B, Jaffe R, Esquivel CO, et al. Adenoviral infections in pediatric liver transplant recipients. JAMA. 1987;258(4):489–92.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  52. McLaughlin GE, Delis S, Kashimawo L, et al. Adenovirus infection in pediatric liver and intestinal transplant recipients: utility of DNA detection by PCR. Am J Transplant. 2003;3(2):224–8.

    Article  PubMed  Google Scholar 

  53. Florescu DF, Islam MK, Mercer DF, et al. Adenovirus infections in pediatric small bowel transplant recipients. Transplantation. 2010;90(2):198–204.

    Article  PubMed  Google Scholar 

  54. Parizhskaya M, Walpusk J, Mazariegos G, Jaffe R. Enteric adenovirus infection in pediatric small bowel transplant recipients. Pediatr Dev Pathol. 2001;4(2):122–8.

    Article  CAS  PubMed  Google Scholar 

  55. Pinchoff RJ, Kaufman SS, Magid MS, et al. Adenovirus infection in pediatric small bowel transplantation recipients. Transplantation. 2003;76(1):183–9.

    Article  PubMed  Google Scholar 

  56. Berho M, Torroella M, Viciana A, et al. Adenovirus enterocolitis in human small bowel transplants. Pediatr Transplant. 1998;2(4):277–82.

    CAS  PubMed  Google Scholar 

  57. Gabriel R, Selwyn S, Brown D, et al. Virus infections and acute renal transplant rejection. Nephron. 1976;16(4):282–6.

    Article  CAS  PubMed  Google Scholar 

  58. Shirali GS, Ni J, Chinnock RE, et al. Association of viral genome with graft loss in children after cardiac transplantation. New Engl J Med. 2001;344(20):1498–503.

    Article  CAS  PubMed  Google Scholar 

  59. Florescu DF, Langnas AN, Sandkovsky U. Opportunistic viral infections in intestinal transplantation. Expert Rev Anti Infect Ther. 2013;11(4):367–81.

    Article  CAS  PubMed  Google Scholar 

  60. Florescu MC, Miles CD, Florescu DF. What do we know about adenovirus in renal transplantation? Nephrol Dial Transplant. 2013;28(8):2003–10.

    Article  PubMed  Google Scholar 

  61. Hofland CA, Eron LJ, Washecka RM. Hemorrhagic adenovirus cystitis after renal transplantation. Transplant Proc. 2004;36(10):3025–7.

    Article  CAS  PubMed  Google Scholar 

  62. Moulik M, Breinholt JP, Dreyer WJ, et al. Viral endomyocardial infection is an independent predictor and potentially treatable risk factor for graft loss and coronary vasculopathy in pediatric cardiac transplant recipients. J Am Coll Cardiol. 2010;56(7):582–92.

    Article  PubMed Central  PubMed  Google Scholar 

  63. Kojaoghlanian T, Flomenberg P, Horwitz MS. The impact of adenovirus infection on the immunocompromised host. Rev Med Virol. 2003;13(3):155–71.

    Article  PubMed  Google Scholar 

  64. Ziring D, Tran R, Edelstein S, et al. Infectious enteritis after intestinal transplantation: incidence, timing, and outcome. Transplantation. 2005;79(6):702–9.

    Article  PubMed  Google Scholar 

  65. Ison MG. Adenovirus infections in transplant recipients. Clin Infect Dis. 2006;43(3):331–9.

    Article  PubMed  Google Scholar 

  66. Humar A, Kumar D, Mazzulli T, et al. A surveillance study of adenovirus infection in adult solid organ transplant recipients. Am J Transplant. 2005;5(10):2555–9.

    Article  PubMed  Google Scholar 

  67. Matthes-Martin S, Boztug H, Lion T. Diagnosis and treatment of adenovirus infection in immunocompromised patients. Expert Rev Anti Infect Ther. 2013;11(10):1017–28.

    Article  CAS  PubMed  Google Scholar 

  68. Seidemann K, Heim A, Pfister ED, et al. Monitoring of adenovirus infection in pediatric transplant recipients by quantitative PCR: report of six cases and review of the literature. Am J Transplant. 2004;4(12):2102–8.

    Article  PubMed  Google Scholar 

  69. Siegel JD, Rhinehart E, Jackson M, Chiarello L, Health Care Infection Control Practices Advisory Committee. Guideline for Isolation precautions: preventing transmission of infectious agents in health care settings. Am J Infect Control. 2007;35(10 Suppl 2):S65–164.

    Article  PubMed  Google Scholar 

  70. Morfin F, Dupuis-Girod S, Mundweiler S, et al. In vitro susceptibility of adenovirus to antiviral drugs is species-dependent. Antivir Ther. 2005;10(2):225–9.

    CAS  PubMed  Google Scholar 

  71. Naesens L, Lenaerts L, Andrei G, et al. Antiadenovirus activities of several classes of nucleoside and nucleotide analogues. Antimicrob Agents Chemother. 2005;49(3):1010–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  72. Asano-Mori Y, Kanda Y, Oshima K, et al. Pharmacokinetics of ganciclovir in haematopoietic stem cell transplantation recipients with or without renal impairment. J Antimicrob Chemother. 2006;57(5):1004–7.

    Article  CAS  PubMed  Google Scholar 

  73. Gilead. Vistide® (cidofovir injection). Foster City, CA: Gilead. 2000. http://www.gilead.com/pdf/vistide.pdf. Accessed 19 May 2014.

  74. Ison MG, Green M. Adenovirus in solid organ transplant recipients. Am J Transplant. 2009;9 Suppl 4:S161–5.

    Article  PubMed  Google Scholar 

  75. Hoffman JA. Adenoviral disease in pediatric solid organ transplant recipients. Pediatr Transplant. 2006;10(1):17–25.

    Article  CAS  PubMed  Google Scholar 

  76. Toth K, Spencer JF, Dhar D, et al. Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model. Proc Natl Acad Sci U S A. 2008;105(20):7293–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  77. Painter W, Robertson A, Trost LC, Godkin S, Lampert B, Painter G. First pharmacokinetic and safety study in humans of the novel lipid antiviral conjugate CMX001, a broad-spectrum oral drug active against double-stranded DNA viruses. Antimicrob Agents Chemother. 2012;56(5):2726–34.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  78. Grimley M, Chemaly R, Englund J, et al. The first interventional trial for adenovirus (AdV): brincidofovir (CMX001) for AdV in HCT. Proceedings of the 53rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC); 10–13 September 2013; Denver, CO. Abstract T-351a.

  79. Marty FM, Winston DJ, Rowley SD, et al. CMX001 to prevent cytomegalovirus disease in hematopoietic-cell transplantation. New Engl J Med. 2013;369(13):1227–36.

    Article  CAS  PubMed  Google Scholar 

  80. Florescu DF, Pergam SA, Neely MN, et al. Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patients. Biol Blood Marrow Transplant. 2012;18(5):731–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  81. Grimley M, Papanicolaou G, Prasad V, et al. CMX001 is a potential treatment for adenovirus infection: preliminary antiviral activity results from an open-label, expanded access study of CMX001 for the treatment of serious or life-threatening diseases caused by double stranded DNA viruses. Proceedings of the 39th Annual Meeting of the European Group for Blood and Marrow Transplantation; 7–10 April 2013; London, UK. Abstract 367.

  82. Grimley M, Prasad V, Kurtzberg J, et al. Twice-weekly brincidofovir (CMX001) shows promising antiviral activity in immunocompromised transplant recipients with asymptomatic adenovirus viremia. Proceedings of the 2014 BMT Tandem Meetings; 26 February–2 March 2014; Grapevine (Dallas), TX. Oral abstract 105.

  83. Feuchtinger T, Matthes-Martin S, Richard C, et al. Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation. Br J Haematol. 2006;134(1):64–76.

    Article  PubMed  Google Scholar 

  84. Leen AM, Christin A, Myers GD, et al. Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation. Blood. 2009;114(19):4283–92.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  85. Leen AM, Bollard CM, Mendizabal AM, et al. Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation. Blood. 2013;121(26):5113–23.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  86. Kneidinger D, Ibrisimovic M, Lion T, Klein R. Inhibition of adenovirus multiplication by short interfering RNAs directly or indirectly targeting the viral DNA replication machinery. Antiviral Res. 2012;94(3):195–207.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Conflict of Interest

Diana Florescu received grants from Chimerix Inc. and CLS Behring. Florescu has served as a consultant for Chimerix Inc. and CLS Behring. Uriel Sandkovsky received research grants from CLS Behring, ViiV Healthcare, GSK and Pfizer. Sandkovsky was a consultant for Rib-X Pharmaceuticals. Luciano Vargas declares no conflicts of interest.

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Authors and Affiliations

  1. Division of Infectious Diseases, Transplant Infectious Diseases Program, University of Nebraska Medical Center, Omaha, NE, USA

    Uriel Sandkovsky & Diana F. Florescu

  2. Transplant Surgery Division, University of Nebraska Medical Center, Omaha, NE, USA

    Luciano Vargas & Diana F. Florescu

  3. Transplant Infectious Diseases Program, University of Nebraska Medical Center, Omaha, NE, 68198-5400, USA

    Diana F. Florescu

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  1. Uriel Sandkovsky
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  2. Luciano Vargas
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  3. Diana F. Florescu
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Correspondence to Diana F. Florescu.

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This article is part of the Topical Collection on Transplant and Oncology

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Sandkovsky, U., Vargas, L. & Florescu, D.F. Adenovirus: Current Epidemiology and Emerging Approaches to Prevention and Treatment. Curr Infect Dis Rep 16, 416 (2014). https://doi.org/10.1007/s11908-014-0416-y

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