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Abstract

Recent advances in understanding toxoplasmosis have been made in the areas of the basic biology of the parasite and the host-parasite interaction, especially the cellular immune response. There is new insight into the biology of the cyst stage that is responsible for meat-associated transmission of infection and for the reactivation of disease in chronically infected humans. Fewer recent advances have been made in clinical diagnosis and treatment of toxoplasmosis. The fascinating revelation that Toxoplasma gondii contains an organelle—now known as the apicoplast—that derives from an algal endosymbiont, has opened many avenues of basic investigation. An understanding of the fundamental biology of T. gondii promises future progress in prevention or treatment of toxoplasmosis.

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References

  1. Dubey JP, Lindsay DS, Speer CA: Structures of Toxoplasma gondii tachyzoites, bradyzoites, and sporozoites and biology and development of tissue cysts. Clin Microbiol Rev 1998, 11:267–299. A beautifully illustrated compendium of the life stages of T. gondii.

    PubMed  CAS  Google Scholar 

  2. Dubey JP: Advances in the life cycle of Toxoplasma gondii. Int J Parasitol 1998, 28:1019–1024.

    Article  PubMed  CAS  Google Scholar 

  3. Zhang YW, Kim K, Ma YF, et al.: Disruption of the Toxoplasma gondii bradyzoite-specific gene BAG1 decreases in vivo cyst formation. Mol Microbiol 1999, 31:691–701.

    Article  PubMed  CAS  Google Scholar 

  4. Weiss LM, Ma YF, Takvorian PM, et al.: Bradyzoite development in Toxoplasma gondii and the hsp70 stress response. Infect Immun 1998, 66:3295–3302. Evidence that heat shock proteins may be of importance in stage switching in T. gondii.

    PubMed  CAS  Google Scholar 

  5. Fichera ME, Roos DS: A plastid organelle as a drug target in apicomplexan parasites. Nature 1997, 390:407–409. The apicoplast of T. gondii is a potential target for both old and new drugs.

    Article  PubMed  CAS  Google Scholar 

  6. Stokkermans TJW, Schwartzman JD, Keenan K, et al.: Inhibition of Toxoplasma gondii replication by dinitroanline herbicides. Exp Parasitol 1996, 84:355–370.

    Article  PubMed  CAS  Google Scholar 

  7. Manger ID, Hehl AB, Boothroyd JC: The surface of Toxoplasma tachyzoites is dominated by a family of glycosylphosphatidylinositol-anchored antigens related to SAG1. Infect Immun 1998, 66:2237–2244.

    PubMed  CAS  Google Scholar 

  8. Seeber F, Dubremetz JF, Boothroyd JC: Analysis of Toxoplasma gondii stably transfected with a transmembrane variant of its major surface protein, SAG1. J Cell Sci 1998, 111(Pt 1):23–29.

    PubMed  CAS  Google Scholar 

  9. Ricard J, Pelloux H, Favier AL, et al.: Toxoplasma gondii: role of the phosphatidylcholine-specific phospholipase C during cell invasion and intracellular development. Exp Parasitol 1999, 91:231–237.

    Article  PubMed  CAS  Google Scholar 

  10. Ortega-Barria E, Boothroyd JC: A Toxoplasma lectin-like activity specific for sulfated polysaccharides is involved in host cell infection. J Biol Chem 1999, 274:1267–1276. This is a candidate for an important interaction with a common surface molecule that might explain the ability of the parasite to traverse various extracellular surfaces.

    Article  PubMed  CAS  Google Scholar 

  11. Karsten V, Qi H, Beckers CJM, et al.: The protozoan parasite Toxoplasma gondii targets proteins to dense granules and the vacuolar space using both conserved and unusual mechanisms. J Cell Biol 1998, 141:1323–1333. How T. gondii sorts proteins and targets them will turn out to be important to understanding the intracellular existence of the parasite.

    Article  PubMed  CAS  Google Scholar 

  12. Alexander J, Hunter CA: Immunoregulation during toxoplasmosis. Chem Immunol 1998, 70:81–102. An excellent review of recent information on the immune mechanism at work in toxoplasmosis.

    Article  PubMed  CAS  Google Scholar 

  13. Denkers EY, Gazzinelli RT: Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection. Clin Microbiol Rev 1998, 11:569–588. Another excellent review of T. gondii immunology.

    PubMed  CAS  Google Scholar 

  14. Channon JY, Suh EI, Seguin RM, et al.: Attachment ligands of viable Toxoplasma gondii induce soluble immunosupressive factors in human monocytes. Infect Immun 1999, 67:2547–2551.

    PubMed  CAS  Google Scholar 

  15. Lepage AC, Buzoni-Gatel D, Bout D, et al.: Gut derived intraepithelial lymphocytes induce long term immunity against Toxoplasma gondii. J Immunol 1998, 161:4902–4908. The important immunologic interactions of T. gondii in the intestinal epithelium are detailed.

    PubMed  CAS  Google Scholar 

  16. Yap GS, Sher A: Effector cells of both nonhemopoietic and hemopoietic origin are required for interferon gamma- and tumor necrosis factor alpha-dependent host resistance to the intracellular pathogen, Toxoplasma gondii. J Exp Med 1999, 189:1083–1091. The origin of important cytokines in acute T. gondii infection is elucidated.

    Article  PubMed  CAS  Google Scholar 

  17. Khan IA, Matsuura T, Kasper LH: Inducible nitric oxide synthase is not required for long-term vaccine-based immunity against Toxoplasma gondii. J Immunol 1998, 161:2994–3000. Understanding the control of chronic infection will involve more than the cytokines important in acute disease.

    PubMed  CAS  Google Scholar 

  18. Seguin R, Kasper LH: Sensitized lymphocytes and CD40 ligation augment interleukin-12 production by human dendritic cells in response to Toxoplasma gondii. J Infect Dis 1999, 179:467–474.

    Article  PubMed  CAS  Google Scholar 

  19. Ajioka JW, Boothroyd JC, Brunk BP, et al.: Gene discovery by EST sequencing in Toxoplasma gondii reveals sequences restricted to the Apicomplexa. Genome Res 1998, 8:18–28. The promise of genomics in understanding T. gondii biology begins to be revealed.

    PubMed  CAS  Google Scholar 

  20. Manger ID, Hehl A, Parmley S, et al.: Expressed sequence tag analysis of the bradyzoite stage of Toxoplasma gondii: identification of developmentally regulated genes. Infect Immun 1998, 66:1632–1637. Further revelations of genomics.

    PubMed  CAS  Google Scholar 

  21. Centers for Disease Control and Prevention: Surveillance for AIDS-defining opportunistic illnesses 1992–1997. MMWR CDC Surveill Summ 1999, 48:12. Recent statistics on the importance of T. gondii infections in AIDS.

    Google Scholar 

  22. Jenum PA, Stray-Pedersen B, Melby KK, et al.: Incidence of Toxoplasma gondii infection in 35,940 pregnant women in Norway and pregnancy outcome for infected women. J Clin Microbiol 1998, 36:2900–2906.

    PubMed  CAS  Google Scholar 

  23. Wilson M, Remington JS, Clavet C, et al.: Evaluation of six commercial kits for detection of human immunoglobulin M antibodies to Toxoplasma gondii: the FDA Toxoplasmosis Ad Hoc Working Group. J Clin Microbiol 1997, 35:3112–3115.

    PubMed  CAS  Google Scholar 

  24. Tuuminen T, Seppanen H, Pitkanen EM, et al.: Improvement of immunoglobulin M capture immunoassay specificity: Toxoplasma antibody detection method as a model. J Clin Microbiol 1999, 37:270–273.

    PubMed  CAS  Google Scholar 

  25. Burnett AJ, Shortt SG, Isaac-Renton J, et al.: Multiple cases of acquired toxoplasmosis retinitis presenting in an outbreak. Ophthalmology 1998, 105:1032–1037. There is more primary ocular toxoplasmosis than we suspected.

    Article  PubMed  CAS  Google Scholar 

  26. Heintzelman MB, Schwartzman JD: A novel class of unconventional myosins from Toxoplasma gondii. J Mol Biol 1997, 271:139–146.

    Article  PubMed  CAS  Google Scholar 

  27. Heintzelman MB, Schwartzman JD: Characterization of myosin-A and myosin-C: two class XIV unconventional myosins from Toxoplasma gondii. Cell Motil Cytoskeleton 1999, 44:58–67.

    Article  PubMed  CAS  Google Scholar 

  28. Dobrowolski J, Sibley LD: The role of the cytoskeleton in host cell invasion by Toxoplasma gondii. Behring Inst Mitt 1997, 99:90–96. A good review of the current understanding of T. gondii motility and invasion.

    PubMed  Google Scholar 

  29. Shaw MK, Tilney LG: Induction of an acrosomal process in Toxoplasma gondii: visualization of actin filaments in a protozoan parasite. Proc Natl Acad Sci U S A 1999, 96:9095–9099.

    Article  PubMed  CAS  Google Scholar 

  30. Lingelbach K, Joiner KA: The parasitophorous vacuole membrane surrounding Plasmodium and Toxoplasma: an unusual compartment in infected cells. J Cell Sci 1998, 111:1467–1475.

    PubMed  CAS  Google Scholar 

  31. Shaw MK, Roos DS, Tilney LG: Acidic compartments and rhoptry formation in Toxoplasma gondii. Parasitology 1998, 117:435–443.

    Article  PubMed  CAS  Google Scholar 

  32. Foulon W, Villena I, Stray-Pedersen B, et al.: Treatment of toxoplasmosis during pregnancy: a multicenter study of impact on fetal transmission and children’s sequelae at age 1 year. Am J Obstet Gynecol 1999, 180:410–415.

    Article  PubMed  CAS  Google Scholar 

  33. Roberts F, Roberts CW, Johnson JJ, et al.: Evidence for the shikimate pathway in apicomplexan parasites. Nature 1998, 393:801–805. Who would have guessed that T. gondii could be inhibited by herbicides? (Why you’ll not get toxoplasmosis on a golf course.)

    Article  PubMed  CAS  Google Scholar 

  34. Conseil V, Soete M, Dubremetz JF: Serine protease inhibitors block invasion of host cells by Toxoplasma gondii. Antimicrob Agents Chemother 1999, 43:1358–1361.

    PubMed  CAS  Google Scholar 

  35. Estes R, Vogel N, Mack D, et al.: Paclitaxel arrests growth of intracellular Toxoplasma gondii. Antimicrob Agents Chemother 1998, 42:2036–2040.

    PubMed  CAS  Google Scholar 

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Schwartzman, J.D. Toxoplasmosis. Curr Infect Dis Rep 3, 85–89 (2001). https://doi.org/10.1007/s11908-001-0063-y

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  • DOI: https://doi.org/10.1007/s11908-001-0063-y

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