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Pathophysiology of Hypertension in the Absence of Nitric Oxide/Cyclic GMP Signaling

  • Hypertension and the Kidney (RM Carey and A Mimran, Section Editors)
  • Published:
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Abstract

The nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling system is a well-characterized modulator of cardiovascular function, in general, and blood pressure, in particular. The availability of mice mutant for key enzymes in the NO-cGMP signaling system facilitated the identification of interactions with other blood pressure modifying pathways (e.g. the renin-angiotensin-aldosterone system) and of gender-specific effects of impaired NO-cGMP signaling. In addition, recent genome-wide association studies identified blood pressure-modifying genetic variants in genes that modulate NO and cGMP levels. Together, these findings have advanced our understanding of how NO-cGMP signaling regulates blood pressure. In this review, we will summarize the results obtained in mice with disrupted NO-cGMP signaling and highlight the relevance of this pathway as a potential therapeutic target for the treatment of hypertension.

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Authors and Affiliations

  1. Molecular Cardiology Research Institute, Molecular Cardiology Research Center, Tufts Medical Center, 800 Washington Street, Box 80, Boston, MA 02111, USA

    Robrecht Thoonen

  2. Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 4312, Charlestown, MA 02129, USA

    Patrick Y. Sips

  3. Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier 505E, Boston, MA 02114, USA

    Kenneth D. Bloch

  4. Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier 511B, Boston, MA, 02114, USA

    Emmanuel S. Buys

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Thoonen, R., Sips, P.Y., Bloch, K.D. et al. Pathophysiology of Hypertension in the Absence of Nitric Oxide/Cyclic GMP Signaling. Curr Hypertens Rep 15, 47–58 (2013). https://doi.org/10.1007/s11906-012-0320-5

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