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Nonmodulation and essential hypertension

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Abstract

Nonmodulation is a process in which there is a disorder in angiotensin-dependent control of the renal circulation and adrenal aldosterone release. The abnormalities are associated with an inability to handle a sodium load and salt-sensitive hypertension. All of the features are corrected by angiotensin-converting enzyme inhibition. A striking family history of hypertension and concordance of responses to angiotensin II in sibling pairs have suggested a familial factor. Genes governing renin substrate (angiotensinogen) production showed gene polymorphisms in nonmodulators. As nonmodulation occurs in approximately 40% of patients with essential hypertension, clearly other genes must contribute.

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Authors and Affiliations

  1. Brigham and Women’s Hospital, 75 Francis Street, 02115, Boston, MA, USA

    Norman K. Hollenberg MD, PhD

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  1. Norman K. Hollenberg MD, PhD
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  2. Gordon H. Williams MD
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Correspondence to Norman K. Hollenberg MD, PhD.

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Hollenberg, N.K., Williams, G.H. Nonmodulation and essential hypertension. Current Science Inc 8, 127–131 (2006). https://doi.org/10.1007/s11906-006-0008-9

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  • DOI: https://doi.org/10.1007/s11906-006-0008-9

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