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Hematopoietic Stem Cell Transplantation in Patients Infected With HIV

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Abstract

Hematopoietic stem cell transplantation (HSCT) replaces a diseased hematopoietic system with a functional, disease-free graft and is frequently used in the treatment of hematologic malignancies. The advent of highly active antiretroviral therapy made it possible to treat medical conditions in HIV-infected patients in the same way as in the general population. Several studies have reported the feasibility, safety, and efficacy of autologous HSCT as rescue or consolidation treatment for non-Hodgkin’s and Hodgkin’s lymphoma in HIV-infected patients. As a result of the improvements in supportive care and the introduction of attenuated transplant conditioning regimens, allogeneic HSCT has been used to treat life-threatening hematologic disorders, with promising results in HIV-infected patients. Moreover, this strategy has made it possible to treat both the hematologic disease and HIV infection.

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Acknowledgments

The authors thank Thomas O’Boyle for writing assistance during the preparation of the manuscript.

Supported by grants from Fundación para la Investigación y la Prevención del SIDA en España (FIPSE), Ref 36290/02 and 36606/06, and Fundación de Investigación Médica Mutua Madrileña, Ref 589/2007.

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No potential conflicts of interest relevant to this article were reported.

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Authors and Affiliations

  1. Servicio de Hematología, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo 46, 28007, Madrid, Spain

    David Serrano, Pascual Balsalobre & José Luis Díez-Martin

  2. Unidad de Enfermedades Infecciosas/VIH, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo 46, 28007, Madrid, Spain

    Pilar Miralles & Juan Berenguer

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  1. David Serrano
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  2. Pilar Miralles
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Correspondence to David Serrano.

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Serrano, D., Miralles, P., Balsalobre, P. et al. Hematopoietic Stem Cell Transplantation in Patients Infected With HIV. Curr HIV/AIDS Rep 7, 175–184 (2010). https://doi.org/10.1007/s11904-010-0050-8

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