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Role of collagen deposition in lymphatic tissues and immune reconstruction during HIV-1 and SIV infections

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Abstract

The hallmark of HIV-1/simian immunodeficiency virus infections is the progressive depletion of CD4+ T cells that ultimately renders the host incapable of defending against AIDS-defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4+ T-cell loss, this review focuses on the growing evidence that collagen deposition and consequent fibrotic damage to the lymphatic tissue T-cell compartment contributes to CD4+ T-cell decline and limits CD4+ T-cell repopulation, even with highly active antiretroviral therapy.

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  1. The AIDS and Cancer Virus Program, Science Applications International Corporation-Frederick, Inc., National Cancer Institute-Frederick, Fort Detrick Campus, Building 535, Room 413b, Frederick, MD, 21702, USA

    Jacob D. Estes

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Estes, J.D. Role of collagen deposition in lymphatic tissues and immune reconstruction during HIV-1 and SIV infections. Curr HIV/AIDS Rep 6, 29–35 (2009). https://doi.org/10.1007/s11904-009-0005-0

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