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Novel Therapies in Acute Lymphoblastic Leukemia

  • Acute Lymphocytic Leukemias (K Ballen and M Keng, Section Editors)
  • Published:
Current Hematologic Malignancy Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Treatment options for patients with acute lymphoblastic leukemia (ALL) beyond standard chemotherapy have grown significantly in recent years. In this review, we highlight new targeted therapies in ALL, with an emphasis on immunotherapy.

Recent Findings

Major advances include antibody-based therapies, such as naked monoclonal antibodies, antibody-drug conjugates and bispecific T cell engaging (BiTE) antibodies, as well as adoptive cellular therapies such as chimeric antigen receptor (CAR) T cells. Apart from the above immunotherapeutic approaches, other targeted therapies are being employed in Philadelphia chromosome-positive (Ph+) ALL, Philadelphia-like (Ph-like) ALL, and T cell ALL.

Summary

These new treatment strategies are changing the treatment landscape of ALL and challenging the current standard of care. Clinical trials will hopefully help determine how to best incorporate these novel therapies into existing treatment algorithms.

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Authors and Affiliations

  1. Cardinal Bernardin Cancer Center, Loyola University Medical Center, 2160 S. First Avenue, Maywood, IL, 60153, USA

    Kathleen W. Phelan

  2. Taussig Cancer Center, Cleveland Clinic, 10201 Carnegie Avenue, Desk CA60, Cleveland, OH, 44195, USA

    Anjali S. Advani

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Kathleen W. Phelan declares that she has no conflict of interest.

Anjali S. Advani has the following financial disclosures: consulting and research support from Pfizer, consulting and honoraria from Novartis, research support from Amgen, and research support from Immunomedics.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Acute Lymphocytic Leukemias

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Phelan, K.W., Advani, A.S. Novel Therapies in Acute Lymphoblastic Leukemia. Curr Hematol Malig Rep 13, 289–299 (2018). https://doi.org/10.1007/s11899-018-0457-7

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  • DOI: https://doi.org/10.1007/s11899-018-0457-7

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