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The Role of Molecular Tests in Acute Myelogenous Leukemia Treatment Decisions

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Abstract

The prognosis for patients with acute myelogenous leukemia (AML) is dependent on age, karyotype, and the genetics of the neoplastic cell. The molecular markers with prognostic impact include mutations in FLT3, NPM1, MLL, WT1, c-KIT, and expression levels of BAALC, NM1, ERG, and CXCR4. Gene expression profiles and microRNA expression patterns in AML may prove highly useful in defining the prognosis of AML. Cytogenetic and, increasingly, molecular findings are used in determining the best therapy for AML patients, especially the choice of whether to perform allogeneic stem cell transplantation.

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Disclosure

Dr. Stone is an ad hoc consultant for Genzyme, Merck, and Celgene. No other potential conflicts of interest relevant to this article were reported.

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  1. Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA, 02115, USA

    Gabriela Motyckova & Richard M. Stone

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  1. Gabriela Motyckova
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Correspondence to Gabriela Motyckova or Richard M. Stone.

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Motyckova, G., Stone, R.M. The Role of Molecular Tests in Acute Myelogenous Leukemia Treatment Decisions. Curr Hematol Malig Rep 5, 109–117 (2010). https://doi.org/10.1007/s11899-010-0049-7

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