Abstract
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma that differs from classic Hodgkin lymphoma (cHL) with respect to histologic and clinical presentation. Because the prognosis of NLPHL in early unfavorable and advanced stages is similar to that of cHL, treatment is similar. In contrast, early favorable-stage NLPHL has a better prognosis than cHL. Thus, NLPHL in early favorable stages might be treated with reduced-intensity programs without compromising cure rates. Because involved-field radiotherapy alone seems to be as effective as extended-field radiotherapy or combined modalities, it has been adopted by the German Hodgkin Study Group and the European Organisation for Research and Treatment of Cancer as the treatment of choice for stage IA NLPHL. Now that efficacy of the monoclonal antibody rituximab has been shown in relapsed NLPHL, its use in the first-line treatment of NLPHL is under investigation.
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References and Recommended Reading
Jost LM, Stahel RA: ESMO minimum clinical recommendations for diagnosis, treatment and follow-up of Hodgkin’s disease. Ann Oncol 2005, 16(Suppl 1):i54–i55.
Ries LA, Kosary CL, Hankey BF, et al.: SEER Cancer Statistics Review: 1973–1994. Bethesda, MD: National Cancer Institute; 1997.
Diehl V, Sextro M, Franklin J, et al.: Clinical presentation, course, and prognostic factors in lymphocyte-predominant Hodgkin’s disease and lymphocyte-rich classical Hodgkin’s disease: report from the European Task Force on Lymphoma Project on Lymphocyte-Predominant Hodgkin’s Disease. J Clin Oncol 1999, 17:776–783.
Anagnostopoulos I, Hansmann ML, Franssila K, et al.: European Task Force on Lymphoma project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes. Blood 2000, 96:1889–1899.
Trudel MA, Krikorian JG, Neiman RS: Lymphocyte predominance Hodgkin’s disease. A clinicopathologic reassessment. Cancer 1987, 59:99–106.
Pappa VI, Norton AJ, Gupta RK, et al.: Nodular type of lymphocyte predominant Hodgkin’s disease. A clinical study of 50 cases. Ann Oncol 1995, 6:559–565.
Nogová L, Reineke T, Eich HT, et al.: Extended field radiotherapy, combined modality treatment or involved field radiotherapy for patients with stage IA lymphocyte-predominant Hodgkin’s lymphoma: a retrospective analysis from the German Hodgkin Study Group (GHSG). Ann Oncol 2005, 16:1683–1687.
Ekstrand BC, Lucas JB, Horwitz SM, et al.: Rituximab in lymphocyte-predominant Hodgkin disease: results of a phase 2 trial. Blood 2003, 101:4285–4289.
Pellegrino B, Terrier-Lacombe MJ, Oberlin O, et al.: Lymphocyte-predominant Hodgkin’s lymphoma in children: therapeutic abstention after initial lymph node resection—a Study of the French Society of Pediatric Oncology. J Clin Oncol 2003, 21:2948–2952.
Mauz-Körholz C, Gorde-Grosjean S, Hasenclever D, et al.: Resection alone in 58 children with limited stage, lymphocyte-predominant Hodgkin lymphoma-experience from the European network group on pediatric Hodgkin lymphoma. Cancer 2007, 110:179–185.
Burns BF, Colby TV, Dorfman RF: Differential diagnostic features of nodular L & H Hodgkin’s disease, including progressive transformation of germinal centers. Am J Surg Pathol 1984, 8:253–261.
Jaffe ES, Harris NL, Stein H, Vardiman JW, eds.: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2001.
Nicholas DS, Harris S, Wright DH: Lymphocyte predominance Hodgkin’s disease—an immunohistochemical study. Histopathology 1990, 16:157–165.
Bracuninger A, Kuppers R, Strickler JG, et al.: Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells. Proc Natl Acad Sci U S A. 1997, 94:9337–9342.
Marafioti T, Pozzobon M, Hansmann ML, et al.: Expression of intracellular signaling molecules in classical and lymphocyte predominance Hodgkin disease. Blood 2004, 103:188–193.
Wickert RS, Weisenburger DD, Tierens A, et al.: Clonal relationship between lymphocytic predominance Hodgkin’s disease and concurrent or subsequent large-cell lymphoma of B lineage. Blood 1995, 86:2312–2320.
Bennett MH, MacLennan KA, Vaughan Hudson G, Vaughan Hudson B: Non-Hodgkin’s lymphoma arising in patients treated for Hodgkin’s disease in the BNLI: a 20-year experience British. National Lymphoma Investigation. Ann Oncol 1991, 2(Suppl 2):83–92.
Huang JZ, Weisenburger DD, Vose JM, et al.: Diffuse large B-cell lymphoma arising in nodular lymphocyte predominant hodgkin lymphoma. A report of 21 cases from the Nebraska Lymphoma Study Group. Leuk Lymphoma 2003, 44:1903–1910.
Nogová L, Reineke T, Brillant C, et al.: Lymphocyte-predominant and classical Hodgkin’s lymphoma: a comprehensive analysis from the German Hodgkin Study Group. J Clin Oncol 2008, 26:434–439.
Nogová L, Reineke T, Josting A, et al.: Lymphocyte-predominant and classical Hodgkin’s lymphoma—comparison of outcomes. Eur J Haematol Suppl 2005, Jul:106–110.
Wirth A, Yuen K, Barton M, et al.: Long-term outcome after radiotherapy alone for lymphocyte-predominant Hodgkin lymphoma: a retrospective multicenter study of the Australasian Radiation Oncology Lymphoma Group. Cancer 2005, 104:1221–1229.
Chera BS, Olivier K, Morris CG, et al.: Clinical presentation and outcomes of lymphocyte-predominant Hodgkin disease at the University of Florida. Am J Clin Oncol 2007, 30:601–606.
Schlembach PJ, Wilder RB, Jones D, et al.: Radiotherapy alone for lymphocyte-predominant Hodgkin’s disease. Cancer J 2002, 8:377–383.
Raemaekers J, Kluin-Nelemans H, Teodorovic I, et al.: The achievements of the EORTC Lymphoma Group. European Organisation for Research and Treatment of Cancer. Eur J Cancer 2002, 38(Suppl 4):S107–S113.
Savage KJ, Hoskins P, Klasa R, et al.: ABVD chemotherapy is essential for optimal treatment of limited stage nodular lymphocyte predominant Hodgkin Lymphoma. Haematologica 2007, 92(Suppl 5):C012.
Schulz H, Rehwald U, Morschhauser F, et al.: Rituximab in relapsed lymphocyte-predominant Hodgkin lymphoma: long-term results of a phase 2 trial by the German Hodgkin Lymphoma Study Group (GHSG). Blood 2008, 111:109–111.
Rehwald U, Schulz H, Reiser M, et al.: Treatment of relapsed CD20+ Hodgkin lymphoma with the monoclonal antibody rituximab is effective and well tolerated: results of a phase 2 trial of the German Hodgkin Lymphoma Study Group. Blood 2003, 101:420–424.
Shimabukuro-Vornhagen A, Haverkamp H, Engert A, et al.: Lymphocyte-rich classical Hodgkin’s lymphoma: clinical presentation and treatment outcome in 100 patients treated within German Hodgkin’s Study Group trials. J Clin Oncol 2005, 23:5739–5745.
Feugier P, Labouyrie E, Djeridane M, et al.: Comparison of initial characteristics and long-term outcome of patients with lymphocyte-predominant Hodgkin lymphoma and classical Hodgkin lymphoma at clinical stages IA and IIA prospectively treated by brief anthracycline-based chemotherapies plus extended high-dose irradiation. Blood 2004, 104:2675–2681.
Fanale MA, Fayad LE, Romaguera JE, et al.: Experience with R-CHOP in patients with lymphocyte predominant Hodgkin Lymphoma (LPHL). Haematologica 2007, 92(Suppl 5):P077.
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Fuchs, M., Eichenauer, D.A., Nogová, L. et al. Nodular lymphocyte-predominant Hodgkin lymphoma. Curr Hematol Malig Rep 3, 126–131 (2008). https://doi.org/10.1007/s11899-008-0019-5
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DOI: https://doi.org/10.1007/s11899-008-0019-5